STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TotFProtein Turandot F; A humoral factor that may play a role in stress tolerance. Belongs to the Turandot family. (125 aa)    
Predicted Functional Partners:
TotB
Turandot B (TotB) encodes a protein that belongs to a class of poorly characterized secreted peptides. Some Turandot genes are expressed in response to stress in the fat body by the JAK-STAT pathway.
   
  
 0.668
TotZ
Turandot Z (TotZ) encodes a protein that belongs to a class of poorly characterized secreted peptides. Some Turandot genes are expressed in response to stress in the fat body by the JAK-STAT pathway.
   
    0.567
CG10140
Uncharacterized protein; Chitin binding. It is involved in the biological process described with: chitin metabolic process.
      
 0.491
CG30080
GEO07755p1.
      
 0.491
TotA
Protein Turandot A; A humoral factor that plays a role in stress tolerance; gives increased resistance to the lethal effects of bacterial challenge and stress. Regulated by the JAK/STAT pathway and NF-KB-like Relish pathway in the fat body, upd3 in the hemocytes and Mekk1 in response to septic injury and consequent immune response. Belongs to the Turandot family.
   
  
 0.451
rk
Rickets (rk) encodes a G-protein coupled receptor that signals intracellularly using the second messenger cAMP. It binds the heterodimeric hormone bursicon and is developmentally important for molting-related behaviors. It is also required after adult emergence for cuticle hardening and melanization.
      
 0.441
dpr11
Defective proboscis extension response 11 (dpr11) encodes a protein involved in axon guidance and regulation of neuromuscular junction development.
      
 0.435
Pburs
Partner of Bursicon (Pburs) encodes a cystine knot protein that dimerizes with the product of Burs to form the bursicon neurohormone that acts on the receptor encoded by rk. Bursicon neurohormone is released after adult emergence and is required for tanning and hardening of the cuticle and expansion of the wings.
      
 0.430
CG42792
GEO02294p1.
   
    0.414
CG42680
HDC02543.
   
    0.412
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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