STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CarTCarcinine transporter (CarT) encodes a transporter belonging to the SLC22A transporter family that is involved in the photoreceptor histamine-carcinine cycle. Histamine neurotransmitter is released by photoreceptors and cleared by uptake into glia, where it is converted to carcinine. The product of CarT transports carcinine back to photoreceptors, where it is hydrolysed by the product of t to restore the pool of histamine; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. (674 aa)    
Predicted Functional Partners:
ine
Sodium- and chloride-dependent GABA transporter ine; Plays a role in neuronal membrane excitation, important for normal response properties of the photoreceptor. Able to control excitability from either neurons or glia cells. Ine negatively regulates neuronal sodium channels. Controls neurotransmitter-mediated signaling pathways associated with the structure of the larval peripheral nerve, ine and eag control perineurial glial growth through partially redundant pathways. Isoform A and isoform B are both functional, although isoform A functions with greater efficiency. Has a role in osm [...]
   
  
 0.890
e
LP19442p; Ebony (e) encodes a protein that links beta-alanine to biogenic amines like dopamine or histamine. It controls the amount of free biogenic amine, e.g. of dopamine in cuticle formation and of histamine in visual signal transduction of the eye. It is also involved in behavioral rhythmicity.
      
 0.839
Hdc
Histidine decarboxylase (Hdc) encodes an enzyme involved in photoreceptor synaptic transmission; Belongs to the group II decarboxylase family.
   
  
 0.837
SLC22A
SLC22A family member (SLC22A) encodes a plasma membrane transporter and a member of the conserved family of SLC22A transporters. The product of SLC22A is preferentially localized in the dendrites of mushroom body neurons, where it functions to terminate synaptic transmission from cholinergic projection neurons through uptake of the released neurotransmitter acetylcholine. Impairing the function of SLC22A enhances the acquisition and retention of olfactory memory by allowing the neurotransmitter signal from projection neurons to be more persistent.
  
  
0.615
rdhB
Retinol dehydrogenase B (rdhB) encodes a retinol dehydrogenase involved in rhodopsin biosynthesis.
   
 
 0.614
Ntl
Transporter; Neurotransmitter transporter-like (Ntl) encodes a glycine transporter of the SLC6 class, closely related to neurotransmitter transporters and other amino acid transporters. Ntl expression is testes-specific and its mutants are male-sterile, producing sperm with a significant reduction in glycylated tubulin; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
   
  
 0.612
lovit
Uncharacterized protein; Sucrose:proton symporter activity.
      
 0.605
CG7458
FI24011p1; Transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport.
  
  
0.536
Tsp
Thrombospondin, isoform A; Thrombospondin (Tsp) is expressed in embryonic tendons and is regulated by sr. The product of Tsp serves as a ligand for the integrin subunit encoded by if and is required for muscle adhesion to tendons.
    
 
 0.536
CG6006
IP17430p; Transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport.
  
  
0.536
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.