| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cen | Cenp-C | FBpp0080929 | FBpp0088911 | Centrocortin, isoform A; Centrocortin (Cen) encodes a protein that regulates cleavage furrow assembly in the early embryo. It localizes to centrosomes asymmetrically, and to cortical actin structures. | Centromeric protein-C (Cenp-C) encodes an essential centromere protein. It binds to the product of cid and provides a binding site for the Mis12 kinetochore protein complex, which is recruited to the centromere at the start of mitotic and meiotic M phases. It also binds the product of cal1, which is crucial for propagation of the epigenetic mark that specifies centromere identity during progression through the cell division cycle. | 0.916 |
| Cen | Fgop2 | FBpp0080929 | FBpp0304603 | Centrocortin, isoform A; Centrocortin (Cen) encodes a protein that regulates cleavage furrow assembly in the early embryo. It localizes to centrosomes asymmetrically, and to cortical actin structures. | FGFR1 oncogene partner 2 homolog; It is involved in the biological process described with: negative regulation of hippo signaling; positive regulation of Ras protein signal transduction; Belongs to the SIKE family. | 0.940 |
| Cen | His3.3A | FBpp0080929 | FBpp0305716 | Centrocortin, isoform A; Centrocortin (Cen) encodes a protein that regulates cleavage furrow assembly in the early embryo. It localizes to centrosomes asymmetrically, and to cortical actin structures. | Histone H3.3A; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes and is specifically enriched in modifications associated with active chromatin. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular mach [...] | 0.811 |
| Cen | His3:CG31613 | FBpp0080929 | FBpp0085250 | Centrocortin, isoform A; Centrocortin (Cen) encodes a protein that regulates cleavage furrow assembly in the early embryo. It localizes to centrosomes asymmetrically, and to cortical actin structures. | Histone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.788 |
| Cen | Ndc80 | FBpp0080929 | FBpp0073681 | Centrocortin, isoform A; Centrocortin (Cen) encodes a protein that regulates cleavage furrow assembly in the early embryo. It localizes to centrosomes asymmetrically, and to cortical actin structures. | LD33040p; Ndc80 (Ndc80) encodes a protein involved in mitotic metaphase plate congression. | 0.827 |
| Cen | RluA-2 | FBpp0080929 | FBpp0079622 | Centrocortin, isoform A; Centrocortin (Cen) encodes a protein that regulates cleavage furrow assembly in the early embryo. It localizes to centrosomes asymmetrically, and to cortical actin structures. | Pseudouridine synthase activity; RNA binding. It is involved in the biological process described with: defense response to Gram-negative bacterium; positive regulation of innate immune response; enzyme-directed rRNA pseudouridine synthesis. | 0.954 |
| Cen | ana2 | FBpp0080929 | FBpp0087766 | Centrocortin, isoform A; Centrocortin (Cen) encodes a protein that regulates cleavage furrow assembly in the early embryo. It localizes to centrosomes asymmetrically, and to cortical actin structures. | Anastral spindle 2 (ana2) encodes a centriole protein that is essential for centriole assembly, promoting the assembly of the central "cartwheel" structure. It may also have an independent role in promoting asymmetric divisions in larval neuroblasts. | 0.779 |
| Cen | cmet | FBpp0080929 | FBpp0304511 | Centrocortin, isoform A; Centrocortin (Cen) encodes a protein that regulates cleavage furrow assembly in the early embryo. It localizes to centrosomes asymmetrically, and to cortical actin structures. | CENP-meta, isoform C; CENP-meta (cmet) encodes a kinetochore kinesin that contributes to metaphase chromosome alignment; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.906 |
| Cen | dup | FBpp0080929 | FBpp0086519 | Centrocortin, isoform A; Centrocortin (Cen) encodes a protein that regulates cleavage furrow assembly in the early embryo. It localizes to centrosomes asymmetrically, and to cortical actin structures. | Double parked (dup) encodes an essential protein for the initiation of DNA replication due to its recruitment of the MCM helicase to replication origins. | 0.959 |
| Cen | geminin | FBpp0080929 | FBpp0085480 | Centrocortin, isoform A; Centrocortin (Cen) encodes a protein that regulates cleavage furrow assembly in the early embryo. It localizes to centrosomes asymmetrically, and to cortical actin structures. | Geminin, isoform A; Geminin (geminin) encodes a protein that interacts with the replication factor encoded by dup and regulates the Egfr pathway, DNA replication and chromosome ploidy. | 0.837 |
| Cenp-C | Cen | FBpp0088911 | FBpp0080929 | Centromeric protein-C (Cenp-C) encodes an essential centromere protein. It binds to the product of cid and provides a binding site for the Mis12 kinetochore protein complex, which is recruited to the centromere at the start of mitotic and meiotic M phases. It also binds the product of cal1, which is crucial for propagation of the epigenetic mark that specifies centromere identity during progression through the cell division cycle. | Centrocortin, isoform A; Centrocortin (Cen) encodes a protein that regulates cleavage furrow assembly in the early embryo. It localizes to centrosomes asymmetrically, and to cortical actin structures. | 0.916 |
| Cenp-C | His3.3A | FBpp0088911 | FBpp0305716 | Centromeric protein-C (Cenp-C) encodes an essential centromere protein. It binds to the product of cid and provides a binding site for the Mis12 kinetochore protein complex, which is recruited to the centromere at the start of mitotic and meiotic M phases. It also binds the product of cal1, which is crucial for propagation of the epigenetic mark that specifies centromere identity during progression through the cell division cycle. | Histone H3.3A; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes and is specifically enriched in modifications associated with active chromatin. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular mach [...] | 0.652 |
| Cenp-C | His3:CG31613 | FBpp0088911 | FBpp0085250 | Centromeric protein-C (Cenp-C) encodes an essential centromere protein. It binds to the product of cid and provides a binding site for the Mis12 kinetochore protein complex, which is recruited to the centromere at the start of mitotic and meiotic M phases. It also binds the product of cal1, which is crucial for propagation of the epigenetic mark that specifies centromere identity during progression through the cell division cycle. | Histone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.652 |
| Cenp-C | Ndc80 | FBpp0088911 | FBpp0073681 | Centromeric protein-C (Cenp-C) encodes an essential centromere protein. It binds to the product of cid and provides a binding site for the Mis12 kinetochore protein complex, which is recruited to the centromere at the start of mitotic and meiotic M phases. It also binds the product of cal1, which is crucial for propagation of the epigenetic mark that specifies centromere identity during progression through the cell division cycle. | LD33040p; Ndc80 (Ndc80) encodes a protein involved in mitotic metaphase plate congression. | 0.913 |
| Cenp-C | cmet | FBpp0088911 | FBpp0304511 | Centromeric protein-C (Cenp-C) encodes an essential centromere protein. It binds to the product of cid and provides a binding site for the Mis12 kinetochore protein complex, which is recruited to the centromere at the start of mitotic and meiotic M phases. It also binds the product of cal1, which is crucial for propagation of the epigenetic mark that specifies centromere identity during progression through the cell division cycle. | CENP-meta, isoform C; CENP-meta (cmet) encodes a kinetochore kinesin that contributes to metaphase chromosome alignment; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.728 |
| Fgop2 | Cen | FBpp0304603 | FBpp0080929 | FGFR1 oncogene partner 2 homolog; It is involved in the biological process described with: negative regulation of hippo signaling; positive regulation of Ras protein signal transduction; Belongs to the SIKE family. | Centrocortin, isoform A; Centrocortin (Cen) encodes a protein that regulates cleavage furrow assembly in the early embryo. It localizes to centrosomes asymmetrically, and to cortical actin structures. | 0.940 |
| Fgop2 | RluA-2 | FBpp0304603 | FBpp0079622 | FGFR1 oncogene partner 2 homolog; It is involved in the biological process described with: negative regulation of hippo signaling; positive regulation of Ras protein signal transduction; Belongs to the SIKE family. | Pseudouridine synthase activity; RNA binding. It is involved in the biological process described with: defense response to Gram-negative bacterium; positive regulation of innate immune response; enzyme-directed rRNA pseudouridine synthesis. | 0.957 |
| Fgop2 | ana2 | FBpp0304603 | FBpp0087766 | FGFR1 oncogene partner 2 homolog; It is involved in the biological process described with: negative regulation of hippo signaling; positive regulation of Ras protein signal transduction; Belongs to the SIKE family. | Anastral spindle 2 (ana2) encodes a centriole protein that is essential for centriole assembly, promoting the assembly of the central "cartwheel" structure. It may also have an independent role in promoting asymmetric divisions in larval neuroblasts. | 0.735 |
| Fgop2 | cmet | FBpp0304603 | FBpp0304511 | FGFR1 oncogene partner 2 homolog; It is involved in the biological process described with: negative regulation of hippo signaling; positive regulation of Ras protein signal transduction; Belongs to the SIKE family. | CENP-meta, isoform C; CENP-meta (cmet) encodes a kinetochore kinesin that contributes to metaphase chromosome alignment; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.651 |
| Fgop2 | dup | FBpp0304603 | FBpp0086519 | FGFR1 oncogene partner 2 homolog; It is involved in the biological process described with: negative regulation of hippo signaling; positive regulation of Ras protein signal transduction; Belongs to the SIKE family. | Double parked (dup) encodes an essential protein for the initiation of DNA replication due to its recruitment of the MCM helicase to replication origins. | 0.960 |
