STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
cadHomeotic protein caudal; Caudal (cad) is one of a number of transcription factors controlling segmentation of the embryo. Further transcriptional regulation via a 5' flanking region containing DNA replication-related elements (DRE) and by dref also regulated by trh and tgo via the CNS midline element. Alongside Bicoid (bcd), caudal forms concentration gradients down the anterior-posterior (A-P) axis providing positional information and subsequent induction of the gap genes. Plays a role in gastrulation/germ band extension, hindgut morphogenesis, positive regulation of cell proliferatio [...] (445 aa)    
Predicted Functional Partners:
l(3)87Df
Lethal (3) 87Df (l(3)87Df) encodes an essential locus required in embryos, early larvae, late pupae and oogenesis.
      
 0.669
Ogg1
DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Efficiently incises DNA duplexes containing 8-hydroxyguanine (8-OH-Gua), 8-hydroxyadenine (8- OH-Ade) and abasic (AP) sites placed opposite to a cytosine.
      
 0.621
Trs31
Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi.
      
 0.603
gcl
Germ cell-less (gcl) encodes a conserved BTB (broad-complex, tramtrack, and bric-a-brac) protein that mediates transcriptional repression in the germline and the degradation of the receptor tyrosine kinase encoded by tor, which in turn allows germ cell formation.
   
  
 0.540
CG11360
LD09246p1; Ubiquitin protein ligase activity; RNA binding; zinc ion binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome.
   
 
 0.531
Timp
Tissue inhibitor of metalloproteinase; Metalloproteinase inhibitor that acts on both matrix metalloproteinases Mmp1 and Mmp2 in vitro. Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor (By similarity). Required for wing maturation which is the final step in morphogenesis of the adult fly. Involved in the negative regulation of developmental tissue invasion for imaginal disk eversion during metamorphosis by inhibiting Mmp-mediated basement membrane (BM) degradation. Required for oogenesis and for the long-term maintainance of [...]
      
 0.529
CG13690
Ribonuclease H2 subunit A; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity).
   
  
 0.499
CG13827
Uncharacterized protein, isoform B; It is involved in the biological process described with: peroxisome fission.
      
 0.440
CG9109
Uncharacterized protein, isoform C; Acetylglucosaminyltransferase activity.
      
 0.440
CG43191
HDC05896.
      
 0.435
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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