node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Blm | PCNA | FBpp0081910 | FBpp0085619 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. | 0.813 |
Blm | RPA2 | FBpp0081910 | FBpp0080967 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Replication protein A2, isoform A; Single-stranded DNA binding. It is involved in the biological process described with: double-strand break repair via homologous recombination; DNA repair; DNA replication; nucleotide-excision repair. | 0.984 |
Blm | RPA3 | FBpp0081910 | FBpp0310183 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Replication protein A3 (RPA3) encodes a protein involved in the maintenance of the neuronal stem cell population. | 0.993 |
Blm | RpA-70 | FBpp0081910 | FBpp0081356 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.997 |
Blm | Top3alpha | FBpp0081910 | FBpp0080787 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | DNA topoisomerase 3-alpha; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils [...] | 0.999 |
Blm | Top3beta | FBpp0081910 | FBpp0309042 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | DNA topoisomerase 3-beta; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. [...] | 0.990 |
Blm | mei-41 | FBpp0081910 | FBpp0074047 | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination. Phosphorylates grp/CHK1. Phosphorylates 'Ser-137' of histone variant H2AX/H2AV at sites of DNA damage, thereby regulating DNA damage response mechanism. [...] | 0.966 |
DNApol-alpha60 | PCNA | FBpp0077899 | FBpp0085619 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit DNApol- alpha180/DNApolA1, an accessory subunit DNApol-alpha73/DNApolA2 and two primase subunits, the catalytic subunit DNApol-alpha50/DNAprim1 and the regulatory subunit DNApol-alpha60/DNAprim2) is recruited to DNA at the replicative forks (B [...] | Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. | 0.968 |
DNApol-alpha60 | RPA2 | FBpp0077899 | FBpp0080967 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit DNApol- alpha180/DNApolA1, an accessory subunit DNApol-alpha73/DNApolA2 and two primase subunits, the catalytic subunit DNApol-alpha50/DNAprim1 and the regulatory subunit DNApol-alpha60/DNAprim2) is recruited to DNA at the replicative forks (B [...] | Replication protein A2, isoform A; Single-stranded DNA binding. It is involved in the biological process described with: double-strand break repair via homologous recombination; DNA repair; DNA replication; nucleotide-excision repair. | 0.955 |
DNApol-alpha60 | RPA3 | FBpp0077899 | FBpp0310183 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit DNApol- alpha180/DNApolA1, an accessory subunit DNApol-alpha73/DNApolA2 and two primase subunits, the catalytic subunit DNApol-alpha50/DNAprim1 and the regulatory subunit DNApol-alpha60/DNAprim2) is recruited to DNA at the replicative forks (B [...] | Replication protein A3 (RPA3) encodes a protein involved in the maintenance of the neuronal stem cell population. | 0.557 |
DNApol-alpha60 | RfC4 | FBpp0077899 | FBpp0073120 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit DNApol- alpha180/DNApolA1, an accessory subunit DNApol-alpha73/DNApolA2 and two primase subunits, the catalytic subunit DNApol-alpha50/DNAprim1 and the regulatory subunit DNApol-alpha60/DNAprim2) is recruited to DNA at the replicative forks (B [...] | Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Subunit 2 binds ATP. | 0.937 |
DNApol-alpha60 | RpA-70 | FBpp0077899 | FBpp0081356 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit DNApol- alpha180/DNApolA1, an accessory subunit DNApol-alpha73/DNApolA2 and two primase subunits, the catalytic subunit DNApol-alpha50/DNAprim1 and the regulatory subunit DNApol-alpha60/DNAprim2) is recruited to DNA at the replicative forks (B [...] | Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.967 |
PCNA | Blm | FBpp0085619 | FBpp0081910 | Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. | Bloom syndrome helicase (Blm) encodes a protein that plays important roles in repairing replication fork damage and double-strand breaks. It promotes repair through non-crossover mechanisms, though it also has roles in meiotic recombination. | 0.813 |
PCNA | DNApol-alpha60 | FBpp0085619 | FBpp0077899 | Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit DNApol- alpha180/DNApolA1, an accessory subunit DNApol-alpha73/DNApolA2 and two primase subunits, the catalytic subunit DNApol-alpha50/DNAprim1 and the regulatory subunit DNApol-alpha60/DNAprim2) is recruited to DNA at the replicative forks (B [...] | 0.968 |
PCNA | RPA2 | FBpp0085619 | FBpp0080967 | Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. | Replication protein A2, isoform A; Single-stranded DNA binding. It is involved in the biological process described with: double-strand break repair via homologous recombination; DNA repair; DNA replication; nucleotide-excision repair. | 0.973 |
PCNA | RPA3 | FBpp0085619 | FBpp0310183 | Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. | Replication protein A3 (RPA3) encodes a protein involved in the maintenance of the neuronal stem cell population. | 0.733 |
PCNA | RfC4 | FBpp0085619 | FBpp0073120 | Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. | Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Subunit 2 binds ATP. | 0.987 |
PCNA | RpA-70 | FBpp0085619 | FBpp0081356 | Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. | Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.871 |
PCNA | Top3alpha | FBpp0085619 | FBpp0080787 | Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. | DNA topoisomerase 3-alpha; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils [...] | 0.403 |
PCNA | Xpac | FBpp0085619 | FBpp0070638 | Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family. | DNA repair protein complementing XP-A cells homolog; Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity). Belongs to the XPA family. | 0.587 |