STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppk13Pickpocket 13; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (460 aa)    
Predicted Functional Partners:
ppk17
Pickpocket 17, isoform A; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
      
 0.837
Ir76b
Ionotropic receptor 76b (Ir76b) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in chemosensory detection of various amines and salt, as a probable co-receptor subunit.
  
   
 0.462
ppk26
Pickpocket 26 (ppk26) encodes a member of the Degenerin/epithelial sodium channel family. In the larva, it regulates locomotion behavior and participates in mechanical nociception together with the product of ppk.
  
   
0.422
ppk6
Pickpocket 6 (ppk6) encodes a member of the DEG/ENaC family, whose members act as non-voltage-gated cation channels. DEG/ENaC family members have been implicated in the maintenance of sodium gradients across epithelial membranes, as well as in diverse sensory modalities, which include gustatory chemosensation, mechanosensation, hygrosensation, and nociception; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
  
   
0.417
aux
Auxilin, isoform A; Auxilin (aux) encodes a co-factor for the ATPase Hsc70 that regulates Clathrin dynamics. It regulates Notch signaling, eye morphogenesis, sperm individualization and neuron death.
      
 0.414
Nach
Sodium channel protein Nach; Nach (Nach) encodes a predicted member of the Degenerin/Epithelial Sodium Channel family of proteins. It is mainly expressed in the tracheal system and functions in liquid clearance during tracheal development; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
  
   
0.408
ppk16
Pickpocket 16; Sodium channel activity. It is involved in the biological process described with: regulation of synaptic activity; sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
  
   
0.401
CG10353
Anoctamin; Chloride channel activity; protein dimerization activity; intracellular calcium activated chloride channel activity. It is involved in the biological process described with: transmembrane transport; chloride transmembrane transport; chloride transport.
      
 0.400
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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