STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Gr39aGustatory and pheromone receptor 39a, isoform C; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Plays a role in sustaining courtship behavior in males, possibly through the reception of a stimulating arrestant pheromone. (381 aa)    
Predicted Functional Partners:
Gr33a
Gustatory and pheromone receptor 33a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for sensing all nonvolatile repulsive chemicals, including tastants, pheromones, and especially N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Functions also as a pheromone receptor for a male inhibitory pheromone leading to male-male courtship suppression. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr66a subfamily.
      
 0.897
Gr23a
Gustatory receptor 23a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily.
   
  
 0.837
Gr89a
Putative gustatory receptor 89a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr77a subfamily.
      
 0.837
Gr93a
Gustatory receptor for bitter taste 93a; Gustatory receptor required for response to the bitter in taste neurons. Gr93a cells respond to bitter compounds such as caffeine. Flies avoid bitter substances, suggesting that Gr93a neuron activity is sufficient to mediate avoidance behavior. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr93a subfamily.
   
  
 0.836
Gr66a
Gustatory receptor for bitter taste 66a; Gustatory receptor required for response to the bitter in taste neurons. Gr66a cells respond to bitter compounds such as caffeine, theophylline, threonine or valine. Flies avoid bitter substances, suggesting that Gr66a neuron activity is sufficient to mediate avoidance behavior. Required for sensing and avoiding N,N- Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide, as well as to L-canavanine, a plant-derived insecticide. Gr66a neurons are also involved in the sex-specific perception of molecules inducing male avoid [...]
      
 0.835
Gr28b
Putative gustatory receptor 28b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Atypical expression suggests also nongustatory roles in the nervous system and tissues involved in proprioception, hygroreception, and other sensory modalities. It is also possible that it has chemosensory roles in the detection of internal ligands; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr66a subfamily.
      
 0.793
Gr28a
Putative gustatory receptor 28a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Atypical expression suggests also nongustatory roles in the nervous system and tissues involved in proprioception, hygroreception, and other sensory modalities. It is also possible that it has chemosensory roles in the detection of internal ligands.
   
  
 0.790
Gr9a
Putative gustatory receptor 9a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
   
  
 0.724
Gr93c
Putative gustatory receptor 93c; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.
   
  
 0.698
ppk8
Pickpocket 8, isoform H; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
   
  
 0.696
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.