node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atg7 | CG17030 | FBpp0085891 | FBpp0073230 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | AT26201p; Ubiquitin protein ligase binding; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process. | 0.601 |
Atg7 | RpL40 | FBpp0085891 | FBpp0306837 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.786 |
Atg7 | RpS27A | FBpp0085891 | FBpp0079606 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...] | 0.604 |
Atg7 | Uba1 | FBpp0085891 | FBpp0087583 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family. | 0.857 |
Atg7 | Ubc10 | FBpp0085891 | FBpp0088522 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | Ubiquitin-conjugating enzyme E2-18 kDa; Ubiquitin-conjugating enzyme E2 that acts with the RBR family ligases LUBEL, ari-1 and possibly parkin. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Appears to be involved in the selective degradation of short-lived and abnormal proteins. Functions with ari-1 to control the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex. Functions by mediating the [...] | 0.613 |
Atg7 | Ubc84D | FBpp0085891 | FBpp0081076 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | Ubiquitin-conjugating enzyme E2-18 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. | 0.719 |
Atg7 | Uev1A | FBpp0085891 | FBpp0076859 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | Ubiquitin-conjugating enzyme variant 1A (Uev1A) encodes a conserved protein that contributes to ubiquitin conjugating enzyme activity, but not catalytically, since it lacks the conserved cysteine residue essential for ubiquitin conjugation. It regulates genomic integrity, IMD pathway-mediated innate immunity, JNK-pathway mediated cell death and tumor invasion. | 0.574 |
Atg7 | park | FBpp0085891 | FBpp0077974 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | Parkin (park) encodes an E3 ubiquitin ligase with a key role in protein ubiquitination. It is involved in mitochondrion organization, oxidative stress and locomotion; Belongs to the RBR family. Parkin subfamily. | 0.914 |
CG17030 | Atg7 | FBpp0073230 | FBpp0085891 | AT26201p; Ubiquitin protein ligase binding; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process. | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | 0.601 |
CG17030 | Gmer | FBpp0073230 | FBpp0071816 | AT26201p; Ubiquitin protein ligase binding; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process. | Probable GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily. | 0.470 |
CG17030 | RpL40 | FBpp0073230 | FBpp0306837 | AT26201p; Ubiquitin protein ligase binding; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.771 |
CG17030 | RpS27A | FBpp0073230 | FBpp0079606 | AT26201p; Ubiquitin protein ligase binding; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process. | Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involve [...] | 0.760 |
CG17030 | Uba1 | FBpp0073230 | FBpp0087583 | AT26201p; Ubiquitin protein ligase binding; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process. | Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family. | 0.591 |
CG17030 | Ubc10 | FBpp0073230 | FBpp0088522 | AT26201p; Ubiquitin protein ligase binding; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process. | Ubiquitin-conjugating enzyme E2-18 kDa; Ubiquitin-conjugating enzyme E2 that acts with the RBR family ligases LUBEL, ari-1 and possibly parkin. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Appears to be involved in the selective degradation of short-lived and abnormal proteins. Functions with ari-1 to control the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex. Functions by mediating the [...] | 0.903 |
CG17030 | Ubc84D | FBpp0073230 | FBpp0081076 | AT26201p; Ubiquitin protein ligase binding; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process. | Ubiquitin-conjugating enzyme E2-18 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. | 0.912 |
CG17030 | Uev1A | FBpp0073230 | FBpp0076859 | AT26201p; Ubiquitin protein ligase binding; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process. | Ubiquitin-conjugating enzyme variant 1A (Uev1A) encodes a conserved protein that contributes to ubiquitin conjugating enzyme activity, but not catalytically, since it lacks the conserved cysteine residue essential for ubiquitin conjugation. It regulates genomic integrity, IMD pathway-mediated innate immunity, JNK-pathway mediated cell death and tumor invasion. | 0.810 |
CG17030 | ari-1 | FBpp0073230 | FBpp0297199 | AT26201p; Ubiquitin protein ligase binding; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process. | E3 ubiquitin-protein ligase ariadne-1; Atypical E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 Ubc10. Controls the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex. Functions by mediating the monoubiquitination of the LINC complex subunit koi leading to its subsequent proteasomal degradation. Appears to function, at least partially redundantly, with the RBR E3 ligase family mem [...] | 0.782 |
CG17030 | park | FBpp0073230 | FBpp0077974 | AT26201p; Ubiquitin protein ligase binding; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process. | Parkin (park) encodes an E3 ubiquitin ligase with a key role in protein ubiquitination. It is involved in mitochondrion organization, oxidative stress and locomotion; Belongs to the RBR family. Parkin subfamily. | 0.618 |
Gmer | CG17030 | FBpp0071816 | FBpp0073230 | Probable GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily. | AT26201p; Ubiquitin protein ligase binding; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process. | 0.470 |
Gmer | RpL40 | FBpp0071816 | FBpp0306837 | Probable GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.759 |