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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RacGAP84CGTPase-activating protein RacGAP84C; Involved in the morphogenesis of the adult appendages. GTPase-activating protein for p21-Rac. Promotes the exchange of Rac- bound GDP by GTP. (384 aa)    
Predicted Functional Partners:
pav
Kinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity.
   
 0.993
pbl
Pebble, isoform B; Pebble (pbl) encodes a Rho guanine nucleotide exchange factor that contributes to multiple processes involving actin cytoskeleton reorganization, including cytokinesis, axogenesis and wound healing as well as cell shape regulation and cell migration during gastrulation.
   
 
 0.901
nesd
Protein nessun dorma; Required during male meiosis for completion of spermatocyte cytokinesis and possibly also required in female germline cells. Also involved in ring canal formation in male and female germline cells. Not essential for cleavage furrow ingression but is required for contractile ring stability and the attachment of the furrowing membrane to the actomyosin ring in late telophase. Displays high binding affinity for beta-galactosides.
   
 0.884
sub
Kinesin-like protein subito; Subito (sub) encodes a kinesin-6 homolog. Kinesin-6 proteins are known to bundle antiparallel microtubules. The product of sub is required for cytokinesis in mitosis and spindle organization and chromosome segregation in female meiosis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
 
 0.879
DNApol-alpha50
DNA primase small subunit; Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit DNApol-alpha180/DNApolA1, an accessory subunit DNApol-alpha73/DNApolA2 and two primase subunits, the catalytic subunit DNApol-alpha50/DNAprim1 and the regulatory subunit DNApol- alpha60/DNAprim2) is recruited to DNA at the replicative forks (By [...]
 
 
    0.807
feo
Fascetto (feo) encodes a protein that binds the central spindle microtubules and is required for proper midbody formation and cytokinesis. It also has roles in centrosome duplication and neurogenesis.
   
 
 0.783
sofe
Sister of feo, isoform A; Microtubule binding. It is involved in the biological process described with: mitotic cytokinesis; G protein-coupled receptor signaling pathway; mitotic spindle midzone assembly; microtubule cytoskeleton organization.
   
 
 0.783
aust
Australin, isoform A; Australin (aust) is a male meiotic specific paralogue of borr, which encodes one of the three targeting subunits for the product of aurB in the chromosomal passenger complex (CPC). The CPC is critical in regulating multiple aspects of cell division, including chromosome condensation, kinetochore function and cytokinesis, through the kinase activity of the product of aurB.
   
  
 0.756
mars
Mars (mars) encodes a microtubule-associated protein that shuttles between the mitotic spindle and the nucleus. It is required for mitotic spindle attachment to the centrosome; Belongs to the SAPAP family.
   
  
 0.719
CG33934
Uncharacterized protein, isoform E; Citrate transmembrane transporter activity; succinate transmembrane transporter activity. It is involved in the biological process described with: sodium ion transport; citrate transport; anion transmembrane transport.
   
  
 0.687
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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