STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GldGlucose dehydrogenase [FAD, quinone] short protein; Glucose dehydrogenase (Gld) encodes a dehydrogenase that belongs to the GMC oxidoreductase family. The product of Gld is essential for the enzymatic modification of the puparium wall that enables the newly developed adult fly to eclose. Gld is also highly expressed in the male and female reproductive tract and its product modulates sperm storage and utilization. (625 aa)    
Predicted Functional Partners:
CG12398
GMC_OxRdtase_N domain-containing protein; Oxidoreductase activity, acting on CH-OH group of donors; oxidoreductase activity; flavin adenine dinucleotide binding. It is involved in the biological process described with: oxidation-reduction process; ecdysteroid metabolic process.
  
  
0.907
Eno
Enolase (Eno) encodes a phosphopyruvate hydratase involved in glucose homeostasis; Belongs to the enolase family.
     
 0.854
Pgm1
Phosphoglucomutase; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family.
   
 
 0.840
Mipp1
Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate (By similarity). Has a role in embryonic tracheal development where it localizes to the leading edge of actively migrating branches. In these leading cells, enhances formation [...]
   
 
 0.837
Ldh
Lactate dehydrogenase (Ldh) encodes a protein involved in myoblast fusion and somatic muscle development; Belongs to the LDH/MDH superfamily. LDH family.
  
 
 0.833
Gapdh2
Glyceraldehyde 3 phosphate dehydrogenase 2 (Gapdh2) encodes a glyceraldehyde-3-phosphate dehydrogenase involved in glucose homeostasis; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
     
 0.825
Pgi
Phosphoglucose isomerase (Pgi) encodes an enzyme involved in glucose homeostasis.
   
 
  0.817
CG9010
Glyceraldehyde-3-phosphate dehydrogenase; Peptidyl-cysteine S-nitrosylase activity; NADP binding; NAD binding; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. It is involved in the biological process described with: oxidation-reduction process; glycolytic process; glucose metabolic process.
   
 
 0.816
Hex-t2
Hexokinase type 2; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate.
   
 
  0.815
Hex-A
Phosphotransferase; Hexokinase A (Hex-A) encodes a hexokinase involved in glucose homeostasis.
   
 
  0.812
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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