STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
zen2Protein zerknuellt 2; Zerknullt-related (zen2) encodes a member of the Antennapedia Complex (ANT-C), one of two Hox gene complexes. zen2 is similar in sequence and expression to the adjacent zen gene. The two are closely linked and they appear to be duplicate copies with zen being the ancestral member of the pair. Despite its similarity to zen, absence of zen2 function has no discernible effect on development or morphology. (252 aa)    
Predicted Functional Partners:
exd
Homeobox protein extradenticle; Transcription factor which acts with the selector homeodomain proteins altering the regulation of downstream target genes such as wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting segmental identity. Delimits the eye field and prevent inappropriate eye development. Required for proper localization of chordotonal organs within the peripheral nervous system.
    
 
 0.564
CG15480
Uncharacterized protein.
      
 0.523
CG1288
FI08143p.
      
 0.497
CG14609
AT27838p.
      
 0.497
DZIP1
Uncharacterized protein, isoform A; Nucleic acid binding. It is involved in the biological process described with: cilium assembly.
      
 0.491
Gpo2
Glycerol-3-phosphate dehydrogenase (quinone) activity; calcium ion binding. It is involved in the biological process described with: glycerol metabolic process; glycerol-3-phosphate metabolic process; oxidation-reduction process; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
      
 0.430
Scr
Homeotic protein Sex combs reduced; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls the segmental transformation of the first to the second thoracic segment (prothorax to mesothorax) and of the labial palps into maxillary palps. In embryo, required for fusion of labial lobes and development of the T1 denticle belt. In adult, expression in the head is necessary for proper development of the labium. In the first thoracic segment of the adult, required [...]
  
  
0.416
pb
Homeotic protein proboscipedia; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls development of mouthparts, and labial and maxillary palps.
  
  
0.411
abd-A
Homeobox protein abdominal-A; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for segmental identity of the second through eighth abdominal segments. Once a pattern of abd-A expression is turned on in a given parasegment, it remains on the more posterior parasegment, so that the complex pattern of expression is built up in the successive parasegments. Appears to repress expression of Ubx whenever they appear in the same cell, but abd-A is repressed [...]
   
  
0.407
alpha-Est3
Alpha-Esterase-3, isoform A; Carboxylic ester hydrolase activity.
      
 0.400
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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