STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cyp313b1Probable cytochrome P450 313b1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (502 aa)    
Predicted Functional Partners:
Cyp303a1
Probable cytochrome P450 303a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
 0.746
Cpr65Ec
Cuticular protein 65Ec; Structural constituent of chitin-based larval cuticle; structural constituent of cuticle. It is involved in the biological process described with: chitin-based cuticle development.
      
 0.609
alpha-Est10
Carboxylic ester hydrolase activity; Belongs to the type-B carboxylesterase/lipase family.
      
 0.606
Cyp304a1
Probable cytochrome P450 304a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
 0.544
GstE10
Glutathione transferase activity. It is involved in the biological process described with: glutathione metabolic process; Belongs to the GST superfamily.
      
 0.541
Cyp308a1
Probable cytochrome P450 308a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
 0.537
sad
Shadow (sad) encodes a cytochrome P450 involved in ecdysteroid biosynthesis. It shows a mitochondrial localization and catalyzes the addition of a hydroxyl group to the 2 carbon of the cholesterol ring. sad mutants fail to undergo head involution, dorsal closure or to secrete cuticle.
  
 
 0.529
spok
Spookier (spok) encodes a cytochrome P450 involved in ecdysteroid biosynthesis that is expressed primarily in the prothoracic gland and is localized in the endoplasmic reticulum. Genetic evidence suggests that the product of spok acts with the products of sro and Cyp6t3 to catalyze conversion of 7 dehydrocholesterol to delta4, diketol during the ecdysone biosynthetic pathway.
  
 
 0.496
spo
Spook (spo) encodes a cytochrome P450 involved in ecdysteroid biosynthesis in the embryo. spo mutants fail to undergo head involution, dorsal closure or to secrete cuticle.
  
 
 0.496
GluRIB
Glutamate receptor IB, isoform B; Ionotropic glutamate receptor activity; signaling receptor activity; extracellular ligand-gated ion channel activity; ligand-gated ion channel activity. It is involved in the biological process described with: cation transport.
      
 0.491
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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