STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ouibTranscription factor Ouib; Transcription factor required for ecdysteroid production in the prothoracic gland by activating transcription of the ecdysteroid biosynthesis gene spok. Binds to the 5'-AGCTTTATTATTTAG-3' DNA sequence in the spok enhancer region. (312 aa)    
Predicted Functional Partners:
spok
Spookier (spok) encodes a cytochrome P450 involved in ecdysteroid biosynthesis that is expressed primarily in the prothoracic gland and is localized in the endoplasmic reticulum. Genetic evidence suggests that the product of spok acts with the products of sro and Cyp6t3 to catalyze conversion of 7 dehydrocholesterol to delta4, diketol during the ecdysone biosynthetic pathway.
   
 
 0.798
nvd
Rieske-domain protein Neverland; Neverland (nvd) encodes an evolutionarily conserved oxygenase-like protein that is required for the biosynthesis pathway of ecdysone. It converts cholesterol to 7-dehydrocholesterol.
   
  
 0.707
spo
Spook (spo) encodes a cytochrome P450 involved in ecdysteroid biosynthesis in the embryo. spo mutants fail to undergo head involution, dorsal closure or to secrete cuticle.
    
 
 0.678
CG8159
RT10616p; Zinc ion binding; DNA-binding transcription factor activity; DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated.
  
  
0.667
CG31457
LD10183p; Protein phosphatase 1 binding; zinc ion binding.
      
 0.627
CG10274
Uncharacterized protein; DNA binding; zinc ion binding; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription, DNA-templated.
  
  
0.625
sro
Shroud (sro) encodes a short-chain dehydrogenase/reductase that is essential for ecdysone biosynthesis. It is hypothesized to work in the conversion of 7-dehydrocholesterol to 5beta-ketodiol; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.606
CG7386
FI21277p1; DNA binding; zinc ion binding; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription, DNA-templated.
 
  
0.597
D19B
GH09076p; DNA binding; DNA-binding transcription factor activity; zinc ion binding. It is involved in the biological process described with: regulation of transcription, DNA-templated.
  
  
0.561
mRpL2
Mitochondrial ribosomal protein L2; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation.
   
 
 0.543
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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