STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG9773Protein unc-50 homolog; May be required for cell surface expression of acetylcholine receptors; Belongs to the unc-50 family. (275 aa)    
Predicted Functional Partners:
RIC-3
RIC3 acetylcholine receptor chaperone (RIC-3) encodes a protein that assists with nicotinic acetylcholine receptor protein folding.
    
 
 0.892
CG5027
LD24073p; Thiol oxidase activity. It is involved in the biological process described with: peptidyl-cysteine oxidation; cell redox homeostasis.
   
  
 0.882
Med
Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain.
 
 
    0.558
Gos28
Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor (By similarity).
   
  
 0.544
PIG-Z
GPI mannosyltransferase 4; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers a fourth mannose to some trimannosyl- GPIs during GPI precursor assembly (By similarity).
   
  
 0.538
Xe7
Xe7, isoform A; Xe7 (Xe7) encodes a protein that contributes to axon guidance and lateral inhibition.
      
 0.531
RhoGAP102A
Rho GTPase activating protein at 102A, isoform D; GTPase activator activity. It is involved in the biological process described with: signal transduction; positive regulation of GTPase activity.
      
 0.524
nAChRalpha4
Nicotinic Acetylcholine Receptor alpha4 (nAChRalpha4) encodes a four-pass transmembrane channel that is part of a nicotinic acetycholine receptor complex. It promotes sleep and its expression level peaks when sleep need is high. Its activity is inhibited by the product of qvr.
      
 0.510
Uxs
UDP-xylose synthase; NAD+ binding; UDP-glucuronate decarboxylase activity.
      
 0.507
Kap-alpha1
Importin subunit alpha; Karyopherin alpha1 (Kap-alpha1) encodes a protein that is involved in spermatogenesis and the nuclear import of the product of yki.
      
 0.491
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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