STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Nepl12Neprilysin-like 12; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (702 aa)    
Predicted Functional Partners:
Ide
Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2.
      
 0.922
Ance-5
Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis.
   
  
 0.844
Ance-4
Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis.
   
  
 0.843
Ance
Angiotensin converting enzyme (Ance) encodes a member of the peptidyl-dipeptidase A family of zinc metallopeptidases. Ance product is an extracellular glycosylated enzyme with a broad substrate specificity, cleaving dipeptides from the carboxy terminus of oligopeptides.
      
 0.842
Ance-2
Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis.
      
 0.841
Ance-3
Angiotensin-converting enzyme; Peptidyl-dipeptidase activity; metallopeptidase activity. It is involved in the biological process described with: proteolysis.
   
  
 0.841
Psn
Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family.
      
 0.683
Nct
Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
      
 0.625
pen-2
Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
      
 0.609
CtsB1
Cathepsin B1 (CtsB1) encodes a papain-like cysteine proteinase involved in lysosomal protein degradation; Belongs to the peptidase C1 family.
      
 0.540
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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