STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ecaTransmembrane emp24 domain-containing protein eca; Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected. Involved in Golgi organization. Belongs to the EMP24/GP25L family. (216 aa)    
Predicted Functional Partners:
bai
Transmembrane emp24 domain-containing protein bai; Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected; Belongs to the EMP24/GP25L family.
   
0.989
CHOp24
CHOp24, isoform A; CHOp24 (CHOp24) encodes a p24 transporter that contributes to the intracellular trafficking between the ER and Golgi. It is required for secretion of Wnt ligands.
   
0.947
p24-1
P24-related-1, isoform A; P24-related-1 (p24-1) encodes a p24 protein that contributes to the secretion of Wnt ligands.
   
0.932
CG9308
IP11573p; Cargo receptor activity. It is involved in the biological process described with: endoplasmic reticulum to Golgi vesicle-mediated transport; Golgi vesicle transport; intracellular protein transport; Golgi organization.
   
 
0.902
opm
Opossum, isoform A; Opossum (opm) encodes a p24 protein that contributes to the secretion of Wnt ligands; Belongs to the EMP24/GP25L family.
    
 
 0.829
Sec22
Secretory 22, isoform B; Secretory 22 (Sec22) encodes a protein involved in Wnt protein secretion; Belongs to the synaptobrevin family.
   
 0.820
p24-2
P24-related-2, isoform A; P24-related-2 (p24-2) encodes a p24-transporter-type protein involved in post-mating oviposition.
  
  
0.803
loj
Logjam, isoform D; Logjam (loj) encodes a p24-transporter-type protein involved in oviposition.
   
 
 0.794
Sec61beta
Sec61 beta subunit (Sec61beta) encodes a protein involved in the regulation of autophagy.
   
 
 0.723
Surf4
Surfeit locus protein 4 homolog; Belongs to the SURF4 family.
   
 0.696
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.