STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
knkKnickkopf (knk) encodes a GPI-anchorded protein, needed for chitin organisation in the cuticle and the tracheal system (tracheal cuticle, tube diameter regulation & gas filling). (689 aa)    
Predicted Functional Partners:
rtv
Retroactive, isoform A; Retroactive (rtv) encodes a membrane-inserted protein required for chitin organization in the cuticle and the tracheal system.
   
  
 0.921
obst-A
Obstructor-A, isoform A; obstructor-A (obst-A) encodes a protein that forms a core complex with chitin and the chitin modifying proteins encoded by serp and knk. This complex is required for assembly, maturation and preservation of the chitinous cuticles at the end of embryogenesis and probably throughout larval development.
   
 
 0.889
verm
Vermiform, isoform I; Vermiform (verm) encodes a chitin deacetylase-like protein that is secreted by tracheal cells and accumulates in the embryonic tracheal lumen. Its functions include cuticle development and tracheal tube size control.
   
  
 0.885
serp
Serpentine, isoform B; Serpentine (serp) encodes a putative chitin deacetylase. It is expressed by the epidermal and tracheal cells and is secreted into the apical extracellular space. Its activity maintains the strength of cuticles and restricts tracheal tube length.
   
  
 0.857
kkv
Krotzkopf verkehrt (kkv) encodes a membrane-inserted glycosyltransferase family 2 chitin synthase that uses GlcNAc to produce the polysaccharide chitin, which is extruded to the differentiating cuticle and tracheal system (tracheal cuticle, tube diameter regulation and gas filling).
   
  
 0.841
TwdlD
RE49895p; TweedleD (TwdlD) encodes a chitin-binding protein that is a member of the Tweedle family of cuticle proteins.
   
  
 0.805
Cht5
Chitinase 5 (Cht5) encodes an enzyme involved in the formation of chitin-based extracellular matrix at barrier tissues; Belongs to the glycosyl hydrolase 18 family.
   
  
 0.725
Gasp
Gasp, isoform A; Gasp (Gasp) encodes a protein involved in cuticle biosynthesis during embryonic tracheal system development.
   
  
 0.638
Cht7
Chitinase 7 (Cht7) encodes an enzyme involved in cuticle development, ecdysis and wound healing; Belongs to the glycosyl hydrolase 18 family.
   
  
 0.636
Cht6
Chitinase 6 (Cht6) encodes an enzyme involved in ecdysis; Belongs to the glycosyl hydrolase 18 family.
   
  
 0.606
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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