STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
Elp1Putative elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs; Belongs to the ELP1/IKA1 family. (1256 aa)    
Predicted Functional Partners:
Elp3
Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at po [...]
   
 0.998
Elp2
Probable elongator complex protein 2; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in the regulation of the STAT pathway ; Belongs to the WD repeat ELP2 family.
   
 0.997
CG2034
Anon-i1 protein; It is involved in the biological process described with: tRNA wobble uridine modification.
   
 0.991
CG3587
EG:39E1.2 protein; It is involved in the biological process described with: regulation of transcription by RNA polymerase II; tRNA wobble uridine modification.
    
 
 0.977
CG6907
Putative elongator complex protein 4; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs; Belongs to the ELP4 family.
   
 0.971
Tsp68C
Tetraspanin 68C (Tsp68C) encodes a member of the tetraspanin superfamily of integral membrane proteins that are involved in cell adhesion and signal transduction. Its proposed functions include the regulation of Notch signaling and the control of Ras/Raf-mediated proliferation in hemocytes; Belongs to the tetraspanin (TM4SF) family.
   
 
 0.941
CG11417
EG:8D8.4 protein; RNA binding. It is involved in the biological process described with: rRNA processing.
   
    0.865
Dph3
DPH3 homolog; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
   
 
 0.847
poly
Poly, isoform A; Poly (poly) encodes a mediator of the InR/TOR signaling pathway. Its functions include growth regulation, cell survival, cell polarization, and establishment/maintenance of interphase higher-order chromatin structures.
    
 0.840
trsn
GM27569p; Translin (trsn) encodes a protein that, together with the product of Trax, forms the Trsn/Trax complex, a ribonuclease that facilitates RNA-induced silencing complex (RISC) activation and has been implicated in many different processes, including starvation-induced sleep suppression.
      
 0.788
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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