STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mfasMidline fasciclin, isoform J; Midline fasciclin (mfas) encodes a protein involved in axonogenesis and regulation of hemocyte proliferation. (905 aa)    
Predicted Functional Partners:
ND-49L
NADH dehydrogenase activity; quinone binding; NADH dehydrogenase (ubiquinone) activity; NAD binding. It is involved in the biological process described with: mitochondrial electron transport, NADH to ubiquinone; Belongs to the complex I 49 kDa subunit family.
    
 
 0.743
ND-49
NADH dehydrogenase (ubiquinone) activity; quinone binding; NAD binding; NADH dehydrogenase activity. It is involved in the biological process described with: mitochondrial electron transport, NADH to ubiquinone; Belongs to the complex I 49 kDa subunit family.
    
 
 0.743
Uggt
UDP-glucose-glycoprotein glucosyltransferase (Uggt) encodes an enzyme that recognizes glycoproteins with folding defects and adds glucose to N-glycans near the misfolded part of the protein. Uggt product is a component of the calnexin cycle and promotes protein folding in the endoplasmic reticulum along with the protein encoded by Cnx99A and Calr; Belongs to the glycosyltransferase 8 family.
   
  
 0.673
GC
Gamma-glutamyl carboxylase (GC) encodes an enzyme involved in peptidyl-glutamic acid carboxylation.
   
  
 0.644
ND-23
NADH dehydrogenase (Ubiquinone) 23 kDa subunit; NADH dehydrogenase activity; 4 iron, 4 sulfur cluster binding. It is involved in the biological process described with: aerobic respiration; mitochondrial ATP synthesis coupled electron transport; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly.
    
 
 0.468
scf
Supercoiling factor (scf) encodes two polypeptides: DCB45 and its N-teminally truncated form Scf. Scf is a nuclear protein that introduces negative supercoils into DNA in conjunction with topoisomerase II. DCB45 is an endoplasmic reticulum-resident protein.
   
  
 0.460
CG43333
RE16941p; Cell adhesion molecule binding. It is involved in the biological process described with: cell adhesion; extracellular matrix organization.
      
0.457
mt:ND4
NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
    
 
 0.448
Dpck
dephospho-CoA kinase activity; ATP binding. It is involved in the biological process described with: coenzyme A biosynthetic process.
 
      0.444
SPARC
Secreted protein, acidic, cysteine-rich (SPARC) encodes a small calcium and growth factor-binding secreted glycoprotein that is enriched in basement membranes. During cell competition, it is expressed in "loser" cells so they can avoid apoptosis mediated by the products of fwe and azot.
   
 
 0.414
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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