STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG3281LD47774p; Zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II. (538 aa)    
Predicted Functional Partners:
RpL18A
60S ribosomal protein L18a; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL20 family.
    
   0.819
CG31211
Uncharacterized protein, isoform B.
      
 0.790
CG8159
RT10616p; Zinc ion binding; DNA-binding transcription factor activity; DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated.
  
  
0.620
BEAF-32
Boundary element-associated factor of 32kD (BEAF-32) encodes a DNA-binding protein with binding sites near transcription start sites. Its roles include chromatin domain insulator function, gene regulation and genome organization.
   
  
 0.609
esn
Espinas (esn) encodes a LIM domain protein that binds to the seven-pass transmembrane cadherin encoded by stan. This stan-esn interplay elicits repulsion between dendritic branches of sensory neurons; Belongs to the prickle / espinas / testin family.
    
 
 0.570
Bgb
Big brother (Bgb) encodes a beta-subunit of the transcription factor complex core binding factor, which is involved in transcription regulation. It regulates hemocyte proliferation and acts redundantly with the product of Bro in embryonic segmentation; Belongs to the CBF-beta family.
   
  
 0.457
Nf-YC
Nuclear factor Y-box C (Nf-YC) encodes a transcription factor involved in axon guidance.
   
  
 0.449
dwg
Deformed wings (dwg) encodes an architectural chromatin protein essential for embryonic development that organizes open chromatin in regulatory regions (predominantly promoters). dwg product binding site was found in the insulator encoded by scs, and its functions include enhancer blocking, support of distant interactions and recruitment of transcription factors.
  
  
0.442
CG8108
LD27033p.
   
 
 0.428
CG8478
Uncharacterized protein, isoform D; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
   
  
 0.428
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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