STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ClC-aChloride channel protein 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport; Belongs to the chloride channel (TC 2.A.49) family. (1193 aa)    
Predicted Functional Partners:
Trpm
Transient receptor potential cation channel trpm; Calcium channel mediating constitutive calcium ion entry. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily.
   
  
 0.699
SecCl
IP12572p; Glycine-gated chloride ion channel activity; extracellular ligand-gated ion channel activity; GABA-A receptor activity; neurotransmitter receptor activity; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
   
  
 0.668
Atox1
Antioxidant 1 copper chaperone (Atox1) null mutants are unable to develop on low-copper food. Furthermore, the intestinal copper importer encoded by Ctr1B, which is regulated by copper demand, fails to be induced upon copper starvation in Atox1 mutant larvae, while intestinal metallothionein is upregulated. This suggests intestinal copper accumulation, combined with insufficient delivery to the rest of the body.
      
 0.601
Clc
Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
      
 0.599
Eglp2
Entomoglyceroporin 2, isoform C; Water channel activity; channel activity. It is involved in the biological process described with: transmembrane transport; renal system process; Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
  
 0.593
Drip
Aquaporin; Drip (Drip) encodes a protein that belongs to the MIP/aquaporin family involved in the transport of water across the cell membrane. In addition to its cellular roles, it has been implicated in regulating aspects of reproduction and aging.
   
  
 0.573
Task7
TWIK-related acid-sensitive K[+] channel 7 (Task7) encodes an ion channel involved in the transmembrane transport of potassium.
      
 0.566
Eglp4
Entomoglyceroporin 4, isoform F; Water channel activity; channel activity. It is involved in the biological process described with: transmembrane transport; renal system process; Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
  
 0.554
Best1
Bestrophin 1 (Best1) encodes a Ca-activated Cl channel. In Drosophila S2 cells, the current of the product of Best1 is activated by calcium and by cell swelling and plays a role in cell volume regulation.
      
 0.536
Nha2
Na[+]/H[+] hydrogen antiporter 2 (Nha2) encodes a protein involved in the transmembrane transport of potassium.
  
  
 0.534
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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