Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Adk1AT16233p; Adenosine kinase activity. It is involved in the biological process described with: purine ribonucleoside salvage; AMP biosynthetic process. (396 aa)    
Predicted Functional Partners:
Aprt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 0.989
Adgf-B
Adenosine deaminase-related growth factor B; Adenosine deaminase activity. It is involved in the biological process described with: inosine biosynthetic process; adenosine catabolic process.
   
 0.980
Adgf-E
Adenosine deaminase-related growth factor E; It is involved in the biological process described with: inosine biosynthetic process.
   
 0.980
AdSL
Adenylosuccinate Lyase (AdSL) encodes a protein that might be a lyase involved in purine nucleotide metabolic process based on orthology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.977
Adgf-D
Adenosine deaminase-related growth factor D (Adgf-D) encodes an adenosine deaminase involved in cell proliferation.
    
 0.973
Ak2
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways; Belongs to the adenylate kinase family. AK2 subfamily.
  
 0.961
AMPdeam
AMP deaminase activity. It is involved in the biological process described with: IMP biosynthetic process; IMP salvage; AMP metabolic process; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
    
 0.960
CG18128
FI08065p; Purine-nucleoside phosphorylase activity. It is involved in the biological process described with: nucleoside metabolic process.
  
 
 0.957
NT5E-2
Ecto-5'-nucleotidase 2 (NT5E-2) encodes a glycosyl phosphatidylinositol (GPI)-linked membrane-bound glycoprotein with 5'-nucleotidase activity that converts extracellular AMP to adenosine; Belongs to the 5'-nucleotidase family.
    
 0.954
veil
Veil, isoform A; Veil (veil) encodes a GPI-linked protein that functions as a 5'-nucleotidase; Belongs to the 5'-nucleotidase family.
    
 0.954
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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