STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
NANSSialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy- D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. Essential for biosynthesis of sialic acids in neurons of the central nervous system. (372 aa)    
Predicted Functional Partners:
Csas
CMP-sialic acid synthase; N-acylneuraminate cytidylyltransferase activity. It is involved in the biological process described with: response to heat; chemical synaptic transmission.
  
 
 0.992
CG15771
LD15807p; Hydrolase activity.
  
 
 0.938
SiaT
Beta-galactoside alpha-2,6-sialyltransferase; Sialyltransferase (SiaT) encodes an enzyme that functions in the sialylation pathway. It is required to produce sialylated glycans, which are important for nervous system function. It contributes to lifespan, locomotor abnormalities, response to heat and neuromuscular junction development; Belongs to the glycosyltransferase 29 family.
      
 0.799
Coq3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
     
 0.680
Gart
Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family.
     
 0.662
CG17065
N-acetylglucosamine-6-phosphate deacetylase activity. It is involved in the biological process described with: N-acetylglucosamine catabolic process; Belongs to the metallo-dependent hydrolases superfamily. NagA family.
      
 0.649
Tmtc3
Protein O-mannosyl-transferase Tmtc3; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.
     
 0.619
ACC
Acetyl-CoA carboxylase (ACC) encodes a ubiquitous metabolic enzyme. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting substrate for fatty acid synthesis. It is essential in the embryo and in the oenocytes (specialized abdominal cells) for the watertightness of the respiratory system. It is required in the fat body for triglyceride storage and in the muscles for locomotor activity.
     
 0.608
eIF2Bgamma
Eukaryotic translation initiation factor 2B subunit gamma; Translation initiation factor activity; nucleotidyltransferase activity; guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: translational initiation; cellular response to hypoxia; cytoplasmic translational initiation.
  
  
 0.549
CG8207
RE21160p; Nucleotidyltransferase activity. It is involved in the biological process described with: biosynthetic process.
  
  
 0.549
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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