| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACC | Coq3 | FBpp0087947 | FBpp0081028 | Acetyl-CoA carboxylase (ACC) encodes a ubiquitous metabolic enzyme. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting substrate for fatty acid synthesis. It is essential in the embryo and in the oenocytes (specialized abdominal cells) for the watertightness of the respiratory system. It is required in the fat body for triglyceride storage and in the muscles for locomotor activity. | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | 0.538 |
| ACC | Gart | FBpp0087947 | FBpp0308722 | Acetyl-CoA carboxylase (ACC) encodes a ubiquitous metabolic enzyme. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting substrate for fatty acid synthesis. It is essential in the embryo and in the oenocytes (specialized abdominal cells) for the watertightness of the respiratory system. It is required in the fat body for triglyceride storage and in the muscles for locomotor activity. | Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | 0.452 |
| ACC | NANS | FBpp0087947 | FBpp0082060 | Acetyl-CoA carboxylase (ACC) encodes a ubiquitous metabolic enzyme. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting substrate for fatty acid synthesis. It is essential in the embryo and in the oenocytes (specialized abdominal cells) for the watertightness of the respiratory system. It is required in the fat body for triglyceride storage and in the muscles for locomotor activity. | Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy- D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. Essential for biosynthesis of sialic acids in neurons of the central nervous system. | 0.608 |
| CG15771 | Csas | FBpp0311780 | FBpp0423255 | LD15807p; Hydrolase activity. | CMP-sialic acid synthase; N-acylneuraminate cytidylyltransferase activity. It is involved in the biological process described with: response to heat; chemical synaptic transmission. | 0.940 |
| CG15771 | NANS | FBpp0311780 | FBpp0082060 | LD15807p; Hydrolase activity. | Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy- D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. Essential for biosynthesis of sialic acids in neurons of the central nervous system. | 0.938 |
| CG17065 | NANS | FBpp0290783 | FBpp0082060 | N-acetylglucosamine-6-phosphate deacetylase activity. It is involved in the biological process described with: N-acetylglucosamine catabolic process; Belongs to the metallo-dependent hydrolases superfamily. NagA family. | Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy- D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. Essential for biosynthesis of sialic acids in neurons of the central nervous system. | 0.649 |
| CG8207 | NANS | FBpp0086475 | FBpp0082060 | RE21160p; Nucleotidyltransferase activity. It is involved in the biological process described with: biosynthetic process. | Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy- D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. Essential for biosynthesis of sialic acids in neurons of the central nervous system. | 0.549 |
| Coq3 | ACC | FBpp0081028 | FBpp0087947 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | Acetyl-CoA carboxylase (ACC) encodes a ubiquitous metabolic enzyme. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting substrate for fatty acid synthesis. It is essential in the embryo and in the oenocytes (specialized abdominal cells) for the watertightness of the respiratory system. It is required in the fat body for triglyceride storage and in the muscles for locomotor activity. | 0.538 |
| Coq3 | Gart | FBpp0081028 | FBpp0308722 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | 0.745 |
| Coq3 | NANS | FBpp0081028 | FBpp0082060 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy- D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. Essential for biosynthesis of sialic acids in neurons of the central nervous system. | 0.680 |
| Csas | CG15771 | FBpp0423255 | FBpp0311780 | CMP-sialic acid synthase; N-acylneuraminate cytidylyltransferase activity. It is involved in the biological process described with: response to heat; chemical synaptic transmission. | LD15807p; Hydrolase activity. | 0.940 |
| Csas | NANS | FBpp0423255 | FBpp0082060 | CMP-sialic acid synthase; N-acylneuraminate cytidylyltransferase activity. It is involved in the biological process described with: response to heat; chemical synaptic transmission. | Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy- D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. Essential for biosynthesis of sialic acids in neurons of the central nervous system. | 0.992 |
| Csas | SiaT | FBpp0423255 | FBpp0072346 | CMP-sialic acid synthase; N-acylneuraminate cytidylyltransferase activity. It is involved in the biological process described with: response to heat; chemical synaptic transmission. | Beta-galactoside alpha-2,6-sialyltransferase; Sialyltransferase (SiaT) encodes an enzyme that functions in the sialylation pathway. It is required to produce sialylated glycans, which are important for nervous system function. It contributes to lifespan, locomotor abnormalities, response to heat and neuromuscular junction development; Belongs to the glycosyltransferase 29 family. | 0.888 |
| Gart | ACC | FBpp0308722 | FBpp0087947 | Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | Acetyl-CoA carboxylase (ACC) encodes a ubiquitous metabolic enzyme. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting substrate for fatty acid synthesis. It is essential in the embryo and in the oenocytes (specialized abdominal cells) for the watertightness of the respiratory system. It is required in the fat body for triglyceride storage and in the muscles for locomotor activity. | 0.452 |
| Gart | Coq3 | FBpp0308722 | FBpp0081028 | Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | 0.745 |
| Gart | NANS | FBpp0308722 | FBpp0082060 | Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy- D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. Essential for biosynthesis of sialic acids in neurons of the central nervous system. | 0.662 |
| NANS | ACC | FBpp0082060 | FBpp0087947 | Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy- D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. Essential for biosynthesis of sialic acids in neurons of the central nervous system. | Acetyl-CoA carboxylase (ACC) encodes a ubiquitous metabolic enzyme. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting substrate for fatty acid synthesis. It is essential in the embryo and in the oenocytes (specialized abdominal cells) for the watertightness of the respiratory system. It is required in the fat body for triglyceride storage and in the muscles for locomotor activity. | 0.608 |
| NANS | CG15771 | FBpp0082060 | FBpp0311780 | Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy- D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. Essential for biosynthesis of sialic acids in neurons of the central nervous system. | LD15807p; Hydrolase activity. | 0.938 |
| NANS | CG17065 | FBpp0082060 | FBpp0290783 | Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy- D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. Essential for biosynthesis of sialic acids in neurons of the central nervous system. | N-acetylglucosamine-6-phosphate deacetylase activity. It is involved in the biological process described with: N-acetylglucosamine catabolic process; Belongs to the metallo-dependent hydrolases superfamily. NagA family. | 0.649 |
| NANS | CG8207 | FBpp0082060 | FBpp0086475 | Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy- D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. Essential for biosynthesis of sialic acids in neurons of the central nervous system. | RE21160p; Nucleotidyltransferase activity. It is involved in the biological process described with: biosynthetic process. | 0.549 |