STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cyp9f2Probable cytochrome P450 9f2; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides; Belongs to the cytochrome P450 family. (516 aa)    
Predicted Functional Partners:
Cpr
NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome p450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome b5 (By similarity). May function to clear the olfactory organ (antennae) from accumulating chemicals. In the N-terminal section; belongs to the flavodoxin family.
 
 
 
 0.913
CG13667
NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog. Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the N-terminal section; belongs to the flavodoxin family.
 
  
 
 0.874
Cyp303a1
Probable cytochrome P450 303a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
 0.726
Cyp12a4
Probable cytochrome P450 12a4, mitochondrial; Has a role in resistance to insecticide lufenuron, but no other insecticides.
  
 
0.708
spok
Spookier (spok) encodes a cytochrome P450 involved in ecdysteroid biosynthesis that is expressed primarily in the prothoracic gland and is localized in the endoplasmic reticulum. Genetic evidence suggests that the product of spok acts with the products of sro and Cyp6t3 to catalyze conversion of 7 dehydrocholesterol to delta4, diketol during the ecdysone biosynthetic pathway.
  
 
 0.590
shd
Ecdysone 20-monooxygenase; Shade (shd) encodes 20-hydroxylase and is responsible for converting Ecdysone into 20-hydroxyecdysone, the active form of the steroid. It is required in all tissues that produce active Ecdysone and thus contributes to larval moulting, metamorphosis, growth, neuroblast diversity and egg chamber maturation; Belongs to the cytochrome P450 family.
  
   0.571
CG9287
COesterase domain-containing protein.
      
 0.533
CG9701
LP05116p; Beta-glucosidase activity. It is involved in the biological process described with: carbohydrate metabolic process; Belongs to the glycosyl hydrolase 1 family.
   
  
 0.515
sxe2
Sex-specific enzyme 2, isoform A; Carboxylic ester hydrolase activity; lipase activity. It is involved in the biological process described with: lipid catabolic process.
    
 
 0.512
CG7798
GEO02684p1; Lysozyme activity. It is involved in the biological process described with: defense response to Gram-negative bacterium; Belongs to the glycosyl hydrolase 22 family.
      
 0.511
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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