Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Cyp313a4Probable cytochrome P450 313a4; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (494 aa)    
Predicted Functional Partners:
sad
Shadow (sad) encodes a cytochrome P450 involved in ecdysteroid biosynthesis. It shows a mitochondrial localization and catalyzes the addition of a hydroxyl group to the 2 carbon of the cholesterol ring. sad mutants fail to undergo head involution, dorsal closure or to secrete cuticle.
  
 
 0.742
Cyp304a1
Probable cytochrome P450 304a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
 
 0.723
phm
Phantom (phm) encodes a cytochrome P450 involved in ecdysteroid biosynthesis. It is an endoplasmic reticulum protein that catalyzes the addition of a hydroxyl group to the 25 carbon of the cholesterol side chain. phm mutants fail to undergo head involution, dorsal closure and cuticle secretion.
  
 
 
 0.540
shd
Ecdysone 20-monooxygenase; Shade (shd) encodes 20-hydroxylase and is responsible for converting Ecdysone into 20-hydroxyecdysone, the active form of the steroid. It is required in all tissues that produce active Ecdysone and thus contributes to larval moulting, metamorphosis, growth, neuroblast diversity and egg chamber maturation; Belongs to the cytochrome P450 family.
  
 
 
 0.519
Cyp308a1
Probable cytochrome P450 308a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
  
0.480
GstE10
Glutathione transferase activity. It is involved in the biological process described with: glutathione metabolic process; Belongs to the GST superfamily.
      
 0.474
Cpr65Ec
Cuticular protein 65Ec; Structural constituent of chitin-based larval cuticle; structural constituent of cuticle. It is involved in the biological process described with: chitin-based cuticle development.
      
 0.470
Cyp12c1
Probable cytochrome P450 12c1, mitochondrial; Heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding. It is involved in the biological process described with: oxidation-reduction process; Belongs to the cytochrome P450 family.
  
 
 
0.468
alpha-Est10
Carboxylic ester hydrolase activity; Belongs to the type-B carboxylesterase/lipase family.
      
 0.467
Cyp18a1
Cytochrome P450-18a1 (Cyp18a1) encodes a P450 enzyme that inactivates the hormone 20 hydroxy ecdysone through addition of an OH group to the 26 carbon of the hormone molecule. It is expressed in many larval tissues. Cyp18a1 mutants result in prepupal lethality due to improper activation kinetics of the transcription factor encoded by ftz-f1.
  
 
 
0.444
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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