node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akh | AkhR | FBpp0073069 | FBpp0089220 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Adipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. | 0.976 |
Akh | AstA | FBpp0073069 | FBpp0084119 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Allatostatin-A; May act as a neurotransmitter or neuromodulator. | 0.836 |
Akh | CCAP | FBpp0073069 | FBpp0083726 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. | 0.899 |
Akh | Crz | FBpp0073069 | FBpp0082386 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Corazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. | 0.799 |
Akh | CrzR | FBpp0073069 | FBpp0303102 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Corazonin receptor (CrzR) encodes a member of the Class A family of G-protein-coupled receptor that transduces the siganl of the neuropeptide encoded by Crz. It is involved in ethanol-induced behavior and ethanol metabolism. | 0.853 |
Akh | Dh44 | FBpp0073069 | FBpp0310724 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Diuretic hormone 44, isoform A; Hormone activity; G protein-coupled receptor binding; diuretic hormone activity; neuropeptide hormone activity. It is involved in the biological process described with: locomotor rhythm; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; body fluid secretion; hormone-mediated signaling pathway. | 0.669 |
Akh | Hug | FBpp0073069 | FBpp0082108 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Protein hugin; Probably has a role in larval molting; Belongs to the pyrokinin family. | 0.754 |
Akh | Ilp2 | FBpp0073069 | FBpp0076058 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway. | 0.841 |
Akh | NPF | FBpp0073069 | FBpp0304075 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Neuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...] | 0.838 |
Akh | sNPF | FBpp0073069 | FBpp0080859 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. | 0.905 |
AkhR | Akh | FBpp0089220 | FBpp0073069 | Adipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | 0.976 |
AkhR | AstA | FBpp0089220 | FBpp0084119 | Adipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. | Allatostatin-A; May act as a neurotransmitter or neuromodulator. | 0.420 |
AkhR | CCAP | FBpp0089220 | FBpp0083726 | Adipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. | Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. | 0.627 |
AkhR | Crz | FBpp0089220 | FBpp0082386 | Adipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. | Corazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. | 0.749 |
AkhR | Ilp2 | FBpp0089220 | FBpp0076058 | Adipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. | Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway. | 0.512 |
AkhR | NPF | FBpp0089220 | FBpp0304075 | Adipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. | Neuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...] | 0.629 |
AkhR | sNPF | FBpp0089220 | FBpp0080859 | Adipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. | Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. | 0.611 |
AstA | Akh | FBpp0084119 | FBpp0073069 | Allatostatin-A; May act as a neurotransmitter or neuromodulator. | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | 0.836 |
AstA | AkhR | FBpp0084119 | FBpp0089220 | Allatostatin-A; May act as a neurotransmitter or neuromodulator. | Adipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. | 0.420 |
AstA | CCAP | FBpp0084119 | FBpp0083726 | Allatostatin-A; May act as a neurotransmitter or neuromodulator. | Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. | 0.840 |