Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG3505CLIP domain-containing serine protease; It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. CLIP subfamily. (360 aa)    
Predicted Functional Partners:
Idgf5
Chitinase-like protein Idgf5; Probably required to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex (By similarity); Belongs to the glycosyl hydrolase 18 family. IDGF subfamily.
   
  
 0.554
MFS12
Major facilitator superfamily transporter 12, isoform A; Transmembrane transporter activity. It is involved in the biological process described with: anion transport; transmembrane transport.
      
 0.535
fat-spondin
Fat-spondin; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: cell adhesion.
   
  
 0.521
Sems
Seminase (Sems) encodes a serine protease produced in male's accessory glands and transferred to females during mating. It is an essential component in the pathway for proteolytic processing of different seminal proteins. It cleaves the metalloprotease encoded by Semp1, which in turn also cleaves the seminal proteins encoded by Acp26Aa and Acp36DE. It is also required for sperm release from storage via regulation of the product of SP.
  
     0.518
Jon25Biii
Jonah 25Biii; Serine-type endopeptidase activity; endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family.
  
     0.518
CG14219
NRF domain-containing protein; Transferase activity, transferring acyl groups other than amino-acyl groups.
      
 0.512
Jon66Ci
Jonah 66Ci; Serine-type endopeptidase activity; endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family.
  
     0.510
CG32277
Peptidase S1 domain-containing protein; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family.
  
     0.509
CG5390
FI06461p; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family.
  
  
0.503
CG13527
Uncharacterized protein, isoform B; It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family.
  
     0.497
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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