node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Nup107 | Nup153 | FBpp0079710 | FBpp0309144 | Nuclear pore complex protein Nup107; Plays a role in nuclear pore complex (NPC) assembly and maintenance. Required for nuclear import of Mad. Plays a role in double strand break repair by relocalizing the heterochromatic double strain breaks (DSBs) to the nuclear periphery as part of the homologous recombination (HR) repair process. Regulates cytokinesis during spermatocyte meiosis by maintaining type-B lamin Lam localization to the spindle envelope. Regulates female gonad development and oogenesis. Belongs to the nucleoporin Nup84/Nup107 family. | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner. Required for nuclear import of Mad. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleopor [...] | 0.998 |
Nup107 | Nup154 | FBpp0079710 | FBpp0309200 | Nuclear pore complex protein Nup107; Plays a role in nuclear pore complex (NPC) assembly and maintenance. Required for nuclear import of Mad. Plays a role in double strand break repair by relocalizing the heterochromatic double strain breaks (DSBs) to the nuclear periphery as part of the homologous recombination (HR) repair process. Regulates cytokinesis during spermatocyte meiosis by maintaining type-B lamin Lam localization to the spindle envelope. Regulates female gonad development and oogenesis. Belongs to the nucleoporin Nup84/Nup107 family. | Nuclear pore complex protein Nup154; Component of the nuclear pore complex. Has a role in the organization of the inner nuclear membrane proteins at the nuclear envelope. In germ cells, plays a role in the nuclear localization of components of the dpp signaling pathways, such as Medea and phosphorylated Mad. Binds to chromatin, and together with Nup62 and Nup93-1, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells. Has a role in female fertility including egg chamber development; in nurse cells, has a r [...] | 0.998 |
Nup107 | Nup188 | FBpp0079710 | FBpp0297623 | Nuclear pore complex protein Nup107; Plays a role in nuclear pore complex (NPC) assembly and maintenance. Required for nuclear import of Mad. Plays a role in double strand break repair by relocalizing the heterochromatic double strain breaks (DSBs) to the nuclear periphery as part of the homologous recombination (HR) repair process. Regulates cytokinesis during spermatocyte meiosis by maintaining type-B lamin Lam localization to the spindle envelope. Regulates female gonad development and oogenesis. Belongs to the nucleoporin Nup84/Nup107 family. | Nucleoporin 188kDa, isoform C; Structural constituent of nuclear pore. It is involved in the biological process described with: RNA export from nucleus; protein import into nucleus; nuclear pore organization. | 0.983 |
Nup107 | Nup205 | FBpp0079710 | FBpp0074567 | Nuclear pore complex protein Nup107; Plays a role in nuclear pore complex (NPC) assembly and maintenance. Required for nuclear import of Mad. Plays a role in double strand break repair by relocalizing the heterochromatic double strain breaks (DSBs) to the nuclear periphery as part of the homologous recombination (HR) repair process. Regulates cytokinesis during spermatocyte meiosis by maintaining type-B lamin Lam localization to the spindle envelope. Regulates female gonad development and oogenesis. Belongs to the nucleoporin Nup84/Nup107 family. | Nuclear pore complex protein Nup205; Plays a role in the nuclear pore complex (NPC) assembly and maintenance, but with limited role in NPC permeability. Required for specific nuclear import pathways such as Mad import. Belongs to the NUP186/NUP192/NUP205 family. | 0.999 |
Nup107 | Nup214 | FBpp0079710 | FBpp0071905 | Nuclear pore complex protein Nup107; Plays a role in nuclear pore complex (NPC) assembly and maintenance. Required for nuclear import of Mad. Plays a role in double strand break repair by relocalizing the heterochromatic double strain breaks (DSBs) to the nuclear periphery as part of the homologous recombination (HR) repair process. Regulates cytokinesis during spermatocyte meiosis by maintaining type-B lamin Lam localization to the spindle envelope. Regulates female gonad development and oogenesis. Belongs to the nucleoporin Nup84/Nup107 family. | Nuclear pore complex protein Nup214; Serves as a docking site in the receptor-mediated import of substrates across the nuclear pore complex including emb, RanGAP and phosphorylated Mad. Protects mbo/Nup88 from proteasomal degradation at the nuclear pore. Together with mbo/Nup88, sequesters emb in the cytoplasm and thereby attenuates nuclear export signal (NES)-mediated nuclear export. Together with mbo/Nup88, required for the nuclear import of the Rel family transcription factors dorsal (dl) and Dorsal-related immunity factor (Dif) and the activation of an immune response. | 0.999 |
Nup107 | Nup35 | FBpp0079710 | FBpp0074372 | Nuclear pore complex protein Nup107; Plays a role in nuclear pore complex (NPC) assembly and maintenance. Required for nuclear import of Mad. Plays a role in double strand break repair by relocalizing the heterochromatic double strain breaks (DSBs) to the nuclear periphery as part of the homologous recombination (HR) repair process. Regulates cytokinesis during spermatocyte meiosis by maintaining type-B lamin Lam localization to the spindle envelope. Regulates female gonad development and oogenesis. Belongs to the nucleoporin Nup84/Nup107 family. | Nucleoporin Nup35; Functions as a component of the nuclear pore complex (NPC) (By similarity). May have a role in the organization of the inner nuclear membrane proteins at the nuclear envelope together with Nup154. | 0.997 |
Nup107 | Nup62 | FBpp0079710 | FBpp0086294 | Nuclear pore complex protein Nup107; Plays a role in nuclear pore complex (NPC) assembly and maintenance. Required for nuclear import of Mad. Plays a role in double strand break repair by relocalizing the heterochromatic double strain breaks (DSBs) to the nuclear periphery as part of the homologous recombination (HR) repair process. Regulates cytokinesis during spermatocyte meiosis by maintaining type-B lamin Lam localization to the spindle envelope. Regulates female gonad development and oogenesis. Belongs to the nucleoporin Nup84/Nup107 family. | Nuclear pore glycoprotein p62; Essential component of the nuclear pore complex (By similarity). The N-terminal is probably involved in nucleocytoplasmic transport (By similarity). The C-terminal is involved in protein- protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of Nup62 to the pore complex (By similarity). Binds to transcriptionally active genes. Negatively regulates chromatin attachment to the nuclear envelope, probably by preventing chromatin tethering by Nup154. | 0.999 |
Nup107 | Nup93-2 | FBpp0079710 | FBpp0082467 | Nuclear pore complex protein Nup107; Plays a role in nuclear pore complex (NPC) assembly and maintenance. Required for nuclear import of Mad. Plays a role in double strand break repair by relocalizing the heterochromatic double strain breaks (DSBs) to the nuclear periphery as part of the homologous recombination (HR) repair process. Regulates cytokinesis during spermatocyte meiosis by maintaining type-B lamin Lam localization to the spindle envelope. Regulates female gonad development and oogenesis. Belongs to the nucleoporin Nup84/Nup107 family. | Structural constituent of nuclear pore. It is involved in the biological process described with: poly(A)+ mRNA export from nucleus; protein import into nucleus; nuclear pore organization. | 0.998 |
Nup107 | Nup98-96 | FBpp0079710 | FBpp0083851 | Nuclear pore complex protein Nup107; Plays a role in nuclear pore complex (NPC) assembly and maintenance. Required for nuclear import of Mad. Plays a role in double strand break repair by relocalizing the heterochromatic double strain breaks (DSBs) to the nuclear periphery as part of the homologous recombination (HR) repair process. Regulates cytokinesis during spermatocyte meiosis by maintaining type-B lamin Lam localization to the spindle envelope. Regulates female gonad development and oogenesis. Belongs to the nucleoporin Nup84/Nup107 family. | Nuclear pore complex protein Nup98-Nup96; Part of the nuclear pore complex (NPC). Required for MAD import as part of the Nup107-160 complex and required for nuclear export of Moe probably via its association with Rae1. Plays a role in nuclear mRNA export. Promotes cell antiviral response by upregulating FoxK-dependent antiviral gene transcription. In germline stem cells, involved in their maintenance and division together with the TGF-Beta and EGFR signaling pathways. In larval lymph glands, has a role in the maintenance of hematopoiesis by regulating Pvr expression. [Nuclear pore comp [...] | 0.999 |
Nup107 | mbo | FBpp0079710 | FBpp0082137 | Nuclear pore complex protein Nup107; Plays a role in nuclear pore complex (NPC) assembly and maintenance. Required for nuclear import of Mad. Plays a role in double strand break repair by relocalizing the heterochromatic double strain breaks (DSBs) to the nuclear periphery as part of the homologous recombination (HR) repair process. Regulates cytokinesis during spermatocyte meiosis by maintaining type-B lamin Lam localization to the spindle envelope. Regulates female gonad development and oogenesis. Belongs to the nucleoporin Nup84/Nup107 family. | Nuclear pore complex protein Nup88; Essential component of nuclear pore complex. Required for the anchoring of Nup214 and emb on the nuclear envelope and thereby attenuates nuclear export signal (NES)-mediated nuclear export. Together with Nup214, required for the nuclear import of the Rel family transcription factors dorsal (dl) and Dorsal-related immunity factor (Dif) and the activation of an immune response. | 0.997 |
Nup153 | Nup107 | FBpp0309144 | FBpp0079710 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner. Required for nuclear import of Mad. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleopor [...] | Nuclear pore complex protein Nup107; Plays a role in nuclear pore complex (NPC) assembly and maintenance. Required for nuclear import of Mad. Plays a role in double strand break repair by relocalizing the heterochromatic double strain breaks (DSBs) to the nuclear periphery as part of the homologous recombination (HR) repair process. Regulates cytokinesis during spermatocyte meiosis by maintaining type-B lamin Lam localization to the spindle envelope. Regulates female gonad development and oogenesis. Belongs to the nucleoporin Nup84/Nup107 family. | 0.998 |
Nup153 | Nup154 | FBpp0309144 | FBpp0309200 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner. Required for nuclear import of Mad. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleopor [...] | Nuclear pore complex protein Nup154; Component of the nuclear pore complex. Has a role in the organization of the inner nuclear membrane proteins at the nuclear envelope. In germ cells, plays a role in the nuclear localization of components of the dpp signaling pathways, such as Medea and phosphorylated Mad. Binds to chromatin, and together with Nup62 and Nup93-1, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells. Has a role in female fertility including egg chamber development; in nurse cells, has a r [...] | 0.998 |
Nup153 | Nup188 | FBpp0309144 | FBpp0297623 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner. Required for nuclear import of Mad. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleopor [...] | Nucleoporin 188kDa, isoform C; Structural constituent of nuclear pore. It is involved in the biological process described with: RNA export from nucleus; protein import into nucleus; nuclear pore organization. | 0.979 |
Nup153 | Nup205 | FBpp0309144 | FBpp0074567 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner. Required for nuclear import of Mad. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleopor [...] | Nuclear pore complex protein Nup205; Plays a role in the nuclear pore complex (NPC) assembly and maintenance, but with limited role in NPC permeability. Required for specific nuclear import pathways such as Mad import. Belongs to the NUP186/NUP192/NUP205 family. | 0.998 |
Nup153 | Nup214 | FBpp0309144 | FBpp0071905 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner. Required for nuclear import of Mad. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleopor [...] | Nuclear pore complex protein Nup214; Serves as a docking site in the receptor-mediated import of substrates across the nuclear pore complex including emb, RanGAP and phosphorylated Mad. Protects mbo/Nup88 from proteasomal degradation at the nuclear pore. Together with mbo/Nup88, sequesters emb in the cytoplasm and thereby attenuates nuclear export signal (NES)-mediated nuclear export. Together with mbo/Nup88, required for the nuclear import of the Rel family transcription factors dorsal (dl) and Dorsal-related immunity factor (Dif) and the activation of an immune response. | 0.999 |
Nup153 | Nup35 | FBpp0309144 | FBpp0074372 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner. Required for nuclear import of Mad. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleopor [...] | Nucleoporin Nup35; Functions as a component of the nuclear pore complex (NPC) (By similarity). May have a role in the organization of the inner nuclear membrane proteins at the nuclear envelope together with Nup154. | 0.990 |
Nup153 | Nup62 | FBpp0309144 | FBpp0086294 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner. Required for nuclear import of Mad. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleopor [...] | Nuclear pore glycoprotein p62; Essential component of the nuclear pore complex (By similarity). The N-terminal is probably involved in nucleocytoplasmic transport (By similarity). The C-terminal is involved in protein- protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of Nup62 to the pore complex (By similarity). Binds to transcriptionally active genes. Negatively regulates chromatin attachment to the nuclear envelope, probably by preventing chromatin tethering by Nup154. | 0.995 |
Nup153 | Nup93-2 | FBpp0309144 | FBpp0082467 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner. Required for nuclear import of Mad. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleopor [...] | Structural constituent of nuclear pore. It is involved in the biological process described with: poly(A)+ mRNA export from nucleus; protein import into nucleus; nuclear pore organization. | 0.997 |
Nup153 | Nup98-96 | FBpp0309144 | FBpp0083851 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner. Required for nuclear import of Mad. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleopor [...] | Nuclear pore complex protein Nup98-Nup96; Part of the nuclear pore complex (NPC). Required for MAD import as part of the Nup107-160 complex and required for nuclear export of Moe probably via its association with Rae1. Plays a role in nuclear mRNA export. Promotes cell antiviral response by upregulating FoxK-dependent antiviral gene transcription. In germline stem cells, involved in their maintenance and division together with the TGF-Beta and EGFR signaling pathways. In larval lymph glands, has a role in the maintenance of hematopoiesis by regulating Pvr expression. [Nuclear pore comp [...] | 0.998 |
Nup153 | mbo | FBpp0309144 | FBpp0082137 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner. Required for nuclear import of Mad. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleopor [...] | Nuclear pore complex protein Nup88; Essential component of nuclear pore complex. Required for the anchoring of Nup214 and emb on the nuclear envelope and thereby attenuates nuclear export signal (NES)-mediated nuclear export. Together with Nup214, required for the nuclear import of the Rel family transcription factors dorsal (dl) and Dorsal-related immunity factor (Dif) and the activation of an immune response. | 0.992 |