node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG2918 | CG6236 | FBpp0290016 | FBpp0082576 | EG:25E8.1 protein; It is involved in the biological process described with: multicellular organism reproduction; cellular response to hypoxia; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway. | FI21235p1; Catalytic activity. It is involved in the biological process described with: multicellular organism reproduction. | 0.433 |
CG2918 | Gp93 | FBpp0290016 | FBpp0084623 | EG:25E8.1 protein; It is involved in the biological process described with: multicellular organism reproduction; cellular response to hypoxia; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway. | Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. | 0.984 |
CG2918 | Hsc70-3 | FBpp0290016 | FBpp0073447 | EG:25E8.1 protein; It is involved in the biological process described with: multicellular organism reproduction; cellular response to hypoxia; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (UPR) (By similarity). | 0.998 |
CG2918 | Hsc70-5 | FBpp0290016 | FBpp0086694 | EG:25E8.1 protein; It is involved in the biological process described with: multicellular organism reproduction; cellular response to hypoxia; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway. | Heat shock 70 kDa protein cognate 5. | 0.654 |
CG2918 | Hsc70Cb | FBpp0290016 | FBpp0292999 | EG:25E8.1 protein; It is involved in the biological process described with: multicellular organism reproduction; cellular response to hypoxia; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway. | Hsc70Cb, isoform G; Hsc70Cb (Hsc70Cb) encodes an HSP110 family protein that interacts physically with the product of DnaJ-1 as a chaperone of misfolded proteins. It functions together with the product of DnaJ-1 to prevent the toxicity of aggregation-prone proteins. | 0.583 |
CG2918 | Hsp83 | FBpp0290016 | FBpp0305095 | EG:25E8.1 protein; It is involved in the biological process described with: multicellular organism reproduction; cellular response to hypoxia; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway. | Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] | 0.856 |
CG2918 | Roe1 | FBpp0290016 | FBpp0086795 | EG:25E8.1 protein; It is involved in the biological process described with: multicellular organism reproduction; cellular response to hypoxia; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway. | GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity). | 0.843 |
CG2918 | Trap1 | FBpp0290016 | FBpp0085482 | EG:25E8.1 protein; It is involved in the biological process described with: multicellular organism reproduction; cellular response to hypoxia; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway. | Trap1, isoform A; Trap1 (Trap1) encodes a mitochondrial chaperone protein of the heat shock protein (HSP90) family. It shows an ATPase activity and is involved in neurodegeneration associated with mitochondrial dysfunction. | 0.796 |
CG2918 | Tsc1 | FBpp0290016 | FBpp0083931 | EG:25E8.1 protein; It is involved in the biological process described with: multicellular organism reproduction; cellular response to hypoxia; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway. | LD23779p; Tsc1 (Tsc1) encodes a tumour suppressor protein that forms a complex with the product of gig. They control cellular growth via antagonizing insulin and TOR signalling pathways. | 0.657 |
CG6236 | CG2918 | FBpp0082576 | FBpp0290016 | FI21235p1; Catalytic activity. It is involved in the biological process described with: multicellular organism reproduction. | EG:25E8.1 protein; It is involved in the biological process described with: multicellular organism reproduction; cellular response to hypoxia; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway. | 0.433 |
CG6236 | CG7182 | FBpp0082576 | FBpp0311665 | FI21235p1; Catalytic activity. It is involved in the biological process described with: multicellular organism reproduction. | LD21269p; Belongs to the heat shock protein 70 family. | 0.444 |
CG6236 | Gp93 | FBpp0082576 | FBpp0084623 | FI21235p1; Catalytic activity. It is involved in the biological process described with: multicellular organism reproduction. | Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. | 0.489 |
CG6236 | Hsc70-3 | FBpp0082576 | FBpp0073447 | FI21235p1; Catalytic activity. It is involved in the biological process described with: multicellular organism reproduction. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (UPR) (By similarity). | 0.519 |
CG6236 | Hsc70-5 | FBpp0082576 | FBpp0086694 | FI21235p1; Catalytic activity. It is involved in the biological process described with: multicellular organism reproduction. | Heat shock 70 kDa protein cognate 5. | 0.452 |
CG6236 | Hsc70Cb | FBpp0082576 | FBpp0292999 | FI21235p1; Catalytic activity. It is involved in the biological process described with: multicellular organism reproduction. | Hsc70Cb, isoform G; Hsc70Cb (Hsc70Cb) encodes an HSP110 family protein that interacts physically with the product of DnaJ-1 as a chaperone of misfolded proteins. It functions together with the product of DnaJ-1 to prevent the toxicity of aggregation-prone proteins. | 0.437 |
CG6236 | Hsp83 | FBpp0082576 | FBpp0305095 | FI21235p1; Catalytic activity. It is involved in the biological process described with: multicellular organism reproduction. | Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] | 0.465 |
CG6236 | Roe1 | FBpp0082576 | FBpp0086795 | FI21235p1; Catalytic activity. It is involved in the biological process described with: multicellular organism reproduction. | GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity). | 0.625 |
CG6236 | Trap1 | FBpp0082576 | FBpp0085482 | FI21235p1; Catalytic activity. It is involved in the biological process described with: multicellular organism reproduction. | Trap1, isoform A; Trap1 (Trap1) encodes a mitochondrial chaperone protein of the heat shock protein (HSP90) family. It shows an ATPase activity and is involved in neurodegeneration associated with mitochondrial dysfunction. | 0.458 |
CG6236 | Tsc1 | FBpp0082576 | FBpp0083931 | FI21235p1; Catalytic activity. It is involved in the biological process described with: multicellular organism reproduction. | LD23779p; Tsc1 (Tsc1) encodes a tumour suppressor protein that forms a complex with the product of gig. They control cellular growth via antagonizing insulin and TOR signalling pathways. | 0.447 |
CG7182 | CG6236 | FBpp0311665 | FBpp0082576 | LD21269p; Belongs to the heat shock protein 70 family. | FI21235p1; Catalytic activity. It is involved in the biological process described with: multicellular organism reproduction. | 0.444 |