STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Gyc89DbSoluble guanylate cyclase 89Db; Heterodimers with Gyc88E are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme. (669 aa)    
Predicted Functional Partners:
Gycalpha99B
Head-specific guanylate cyclase; Guanylyl cyclase alpha-subunit at 99B (Gycalpha99B) encodes a guanylate cyclase involved in cyclic GMP biosynthesis and phototaxis mediated by rhodopsin.
  
0.991
Gyc89Da
Soluble guanylate cyclase 89Da; Heterodimers with Gyc-89Da and Gyc-89Db are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme.
  
0.979
Gycbeta100B
Guanylyl cyclase beta-subunit at 100B (Gycbeta100B) encodes an enzyme that synthesizes cyclic GMP and is activated by nitric oxide; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  
  
0.939
Gyc88E
Soluble guanylate cyclase 88E; Heterodimers with Gyc-89Da and Gyc-89Db are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme.
  
 
0.926
CG8891
Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
 0.902
Apf
Diadenosine tetraphosphate hydrolase; Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity.
     
 0.901
Mocs1
Cyclic pyranopterin monophosphate synthase; Isoform Mocs1a and isoform Mocs1b probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). Mocs1a catalyzes the cyclization of GTP to (8S)- 3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and Mocs1b catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'- triphosphate to cPMP; In the C-terminal section; belongs to the MoaC family.
   
 
 0.804
Pu
GTP cyclohydrolase 1; Isoform B is required for eye pigment production, Isoform C may be required for normal embryonic development and segment pattern formation.
     
 0.802
Pde11
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
  
 0.757
Pde6
cGMP-specific 3',5'-cyclic phosphodiesterase; Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Has cAMP phosphodiesterase activity in vitro but not in vivo. Has a role regulating cGMP transport in Malpighian tubule principal cells.
   
 0.707
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.