STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
sllSlalom (sll) encodes the first transporter of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), that transfers PAPS from cytosol into the lumen of Golgi. It contributes to the sulfation of glycans and proteins, the regulation of several signaling pathways (Hh, Wingless) mediated by glycosaminoglycans during patterning and morphogenesis, and the determination of the embryonic dorsal/ventral axis; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. (465 aa)    
Predicted Functional Partners:
frc
UDP-sugar transporter UST74c; Involved in the import of UDP-sugars from the cytoplasm into the Golgi lumen; Belongs to the TPT transporter family. SLC35D subfamily.
   
  
 0.921
Efr
UDP-xylose and UDP-N-acetylglucosamine transporter; Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc), GDP-fucose and UDP-xylose. Functions redundantly with nac in the O-fucosylation of Notch, positively regulating Notch signaling. Involved in the biosynthesis of heparan sulfate-glycosaminoglycan (HS-GAG) and in Dpp signaling in the wing imaginal disk; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
   
  
 0.897
sotv
Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan- sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Plays a central role in diffusion of morphogens hedgehog (hh), wingless (wg) and Decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of Hh, Dpp and wg morphogens.
   
  
 0.790
RpL15
60S ribosomal protein L15; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL15 family.
 
      0.772
nac
GDP-fucose transporter 1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen. Plays a major role in the fucosylation of N-glycans. Functions redundantly with Efr in the O-fucosylation of Notch, positively regulating Notch signaling; Belongs to the TPT transporter family. SLC35C subfamily.
   
  
 0.675
CG14511
IP10585p; Transmembrane transporter activity; UDP-N-acetylglucosamine transmembrane transporter activity; UDP-xylose transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport.
   
  
 0.660
Uxs
UDP-xylose synthase; NAD+ binding; UDP-glucuronate decarboxylase activity.
  
  
 0.657
senju
UDP-galactose transporter senju; UDP-galactose transporter involved in the synthesis of galactose-containing glycans. Plays a role in quiescence of the innate immune response, possibly by regulating glycosylation of the Toll pathway ligand spz.
   
  
 0.656
CG14971
FI19868p1; Transmembrane transporter activity; antiporter activity. It is involved in the biological process described with: UDP-glucose transmembrane transport.
   
  
 0.631
CG14621
Solute carrier family 35 member E1 homolog; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily.
   
 
 0.630
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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