STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG4360Uncharacterized protein, isoform A; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II. (556 aa)    
Predicted Functional Partners:
CG42668
Oxysterol-binding protein; Lipid binding; cholesterol binding; sterol binding; sterol transporter activity. It is involved in the biological process described with: phospholipid transport; Belongs to the OSBP family.
      
 0.680
CG12506
GEO10310p1.
      
 0.669
wrd
Well-rounded, isoform B; Well-rounded (wrd) encodes one of the two regulatory B' subunits of the protein phosphatase PP2A. It influences metabolism and growth via negative regulation of the InR/TOR signalling network.
   
   0.561
bon
Bonus, isoform C; Bonus (bon) encodes a nuclear receptor cofactor involved in axon guidance and chromatin organization.
   
 0.550
CG8301
LD25464p; Nucleic acid binding; zinc ion binding.
  
  
 
0.529
Deaf1
Deformed epidermal autoregulatory factor 1; Transcription factor that binds the homeotic Deformed (Dfd) response element. High affinity binding sites contain at least 1 TTCG motif surrounded by additional TCG sequences. May be involved in the selective action of Dfd on these sites without binding directly to the Dfd protein. Requirement of DEAF1 activity may be a common feature of enhancers targeted by Dfd.
   
  
 0.528
CG4362
MIP22975p.
      
 0.523
CG5245
Uncharacterized protein; RNA polymerase II regulatory region sequence-specific DNA binding; zinc ion binding.
  
 
 
0.505
Adf1
Transcription factor Adf-1; May play an important role not only in the regulation of Adh expression but also in the transcription of other genes.
   
  
 0.502
l(2)gl
Lethal(2) giant larvae protein; Essential for the development of polarized epithelia, for cell polarity associated with asymmetric cell division of neuroblasts during development, and for oocyte polarity formation. Promotes the formation of actin-rich projections at the oocyte cortex and the posterior enrichment of par-1 which is required for oocyte polarization. Regulates the localization of axis-specifying morphogens such as stau and grk. [Isoform p127]: Has an accessory function in control of cell proliferation and differentiation during development.
      
 0.461
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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