STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG5862DDRGK domain-containing protein 1; Ubiquitin-like protein ligase binding. It is involved in the biological process described with: positive regulation of NF-kappaB transcription factor activity; Belongs to the DDRGK1 family. (309 aa)    
Predicted Functional Partners:
CG30291
CDK5RAP3-like protein; Probable regulator of cell proliferation. May regulate CDK5, NF-kappa-B-mediated gene transcription and p53/TP53 activation. Belongs to the CDK5RAP3 family.
   
 
 0.968
Ufl1
E3 UFM1-protein ligase 1 homolog; E3 UFM1-protein ligase that mediates ufmylation of target proteins; Belongs to the UFL1 family.
   
 
 0.960
Ufc1
Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage (By similarity). As part of Ufm1 cascade, might play a role in the development of the neuromuscular junctions.
   
 
 0.903
Ufm1
Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine- linked polymer (By similarity). The so-called ufmylation, requires the UFM1-activating E1 enzyme Uba5, the UFM1-conjugating E2 enzyme Ufc1, and the UFM1-ligase E3 enzyme Ufl1 (By similarity). This post- translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes (By similarity). The Ufm1 cascade might play a role in the development of the neuromuscular junctions.
    
 
 0.867
Uba5
Ubiquitin-like activating enzyme 5 (Uba5) encodes a member of the E1-like ubiquitin-activating enzyme family. It activates the protein encoded by Ufm1, and acts as a key factor in the ufmylation process. It is involved in ATP binding, catalytic activity, cofactor binding, metal ion binding, nucleotide binding and oxidoreductase activity.
   
  
 0.701
CG16979
Probable Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins.
    
 
 0.649
SrpRalpha
Signal recognition particle receptor subunit alpha homolog; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May have a role in axonogenesis.
   
 
 0.509
CG11123
RH42110p; RNA binding.
    
 
 0.503
CG30157
Probable Ufm1-specific protease 1; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins; Belongs to the peptidase C78 family.
    
 
 0.461
prod
Non-histone chromosomal protein Prod; It is involved in the biological process described with: mitotic chromosome condensation; regulation of circadian rhythm; lymph gland development.
   
  
 0.448
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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