STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
tinMuscle-specific homeobox protein tinman; Required for the development of heart and visceral muscle; for the formation of somatic muscles. Has a crucial function in the early mesodermal subdivisions. (416 aa)    
Predicted Functional Partners:
Mef2
Myocyte-specific enhancer factor 2; Transcription factor that could be a key player in early mesoderm differentiation and may be required for subsequent cell fate specifications within the somatic and visceral/heart mesodermal layers. Essential for myoblast fusion and consequently muscle formation in adults. During embryonic and pupal development, binds to the enhancer of the myoblast fusion gene sing and activates its transcription. Belongs to the MEF2 family.
    
 
 0.977
mid
Midline, isoform A; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription corepressor binding.
   
 
 0.959
pnr
GATA-binding factor A; Transcriptional regulator involved in several developmental processes during embryonic and imaginal disks development. Involved in determining dorsal cell fate. Acts as an essential transcriptional regulator of proneural achaete-scute complex (AS-C) and is required for its spatial regulation during development of the adult peripheral nervous system, and hence for the positioning of neural precursors. It is the only factor to directly activate AS-C genes.
   
 
 0.897
Hand
FI14601p; Hand (Hand) encodes a transcription factor that contributes to cardiogenesis, hemopoiesis, and muscle function.
   
 
 0.888
bin
Forkhead box protein biniou; Component of a regulatory network controlling visceral mesoderm development and midgut morphogenesis. Transcriptional regulator involved in the activation of a large number of genes in the visceral mesoderm including betaTub60D, dpp and Hand. Binds to and regulates a number of enhancers driving expression in the visceral mesoderm in a temporally and spatially restricted manner. Also to binds to enhancers cooperatively with activators, such as bap or HLH54F, to coregulate expression of shared target genes in the visceral mesoderm. Binds to the Ndg enhancer a [...]
   
 
 0.856
twi
Twist (twi) encodes a transcription factor required for mesoderm cell fate. The product of twi is essential for gastrulation, the development of mesodermal derivatives, including somatic and visceral muscle, fat body and maintenance of muscle stem cells.
   
  
 0.853
dpp
Protein decapentaplegic; Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development [...]
   
  
 0.844
svp
Steroid receptor seven-up, isoform A; Receptor that is required in photoreceptors R1, R3, R4 and R6 during eye development; generation of the ganglion mother cell-2 (GMC- 2) fate in the nb7-3 lineage, coinciding with the transition in the expression of HB to KR in the neuroblasts (NBs). Belongs to the nuclear hormone receptor family. NR2 subfamily.
    
 
 0.843
tup
Tailup, isoform A; Tailup (tup) encodes a transcription factor that regulates neuronal sub-type identity, including motor, serotonergic and dopaminergic neuron identity. It regulates germ band retraction, dorsal closure, muscle and heart development.
   
 
 0.816
zfh1
Zinc finger protein 1; Involved in the development of the embryonic central nervous system, embryonic mesoderm and adult musculature. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
    
 
 0.760
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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