STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
bapHomeobox protein bagpipe; Bagpipe (bap) encodes an important homeodomain transcription factor for visceral mesoderm formation, which differentiates into gut musculature. (382 aa)    
Predicted Functional Partners:
bin
Forkhead box protein biniou; Component of a regulatory network controlling visceral mesoderm development and midgut morphogenesis. Transcriptional regulator involved in the activation of a large number of genes in the visceral mesoderm including betaTub60D, dpp and Hand. Binds to and regulates a number of enhancers driving expression in the visceral mesoderm in a temporally and spatially restricted manner. Also to binds to enhancers cooperatively with activators, such as bap or HLH54F, to coregulate expression of shared target genes in the visceral mesoderm. Binds to the Ndg enhancer a [...]
   
 
 0.964
Mef2
Myocyte-specific enhancer factor 2; Transcription factor that could be a key player in early mesoderm differentiation and may be required for subsequent cell fate specifications within the somatic and visceral/heart mesodermal layers. Essential for myoblast fusion and consequently muscle formation in adults. During embryonic and pupal development, binds to the enhancer of the myoblast fusion gene sing and activates its transcription. Belongs to the MEF2 family.
    
 
 0.833
Hand
FI14601p; Hand (Hand) encodes a transcription factor that contributes to cardiogenesis, hemopoiesis, and muscle function.
    
 
 0.666
lmd
Lame duck (lmd) encodes a zinc finger transcription factor expressed in the embryonic somatic and visceral mesoderm, where it is essential for the specification of fusion competent myoblasts and for myoblast fusion.
   
  
 0.664
twi
Twist (twi) encodes a transcription factor required for mesoderm cell fate. The product of twi is essential for gastrulation, the development of mesodermal derivatives, including somatic and visceral muscle, fat body and maintenance of muscle stem cells.
   
  
 0.663
Six4
Homeobox protein SIX4; Six4 (Six4) encodes a homeodomain-containing transcription factor required for mesodermal patterning to form the embryonic gonad.
   
  
 0.649
Poxm
Paired box pox-meso protein; Pox meso (Poxm) encodes a transcription factor that contributes to dendrite morphogenesis and the development and specification of somatic muscle.
   
  
 0.647
zfh1
Zinc finger protein 1; Involved in the development of the embryonic central nervous system, embryonic mesoderm and adult musculature. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
      
 0.633
org-1
Optomotor-blind-related-gene-1, isoform A; Optomotor-blind-related-gene-1 (org-1) encodes a T-box transcription factor involved in the combinatorial activation of somatic muscle lineage-specific targets.
   
 
 0.617
jeb
Jelly belly (jeb) encodes a secreted, low-density lipoprotein (LDL) repeat containing protein that functions as signalling ligand for the product of Alk. Binding of the ligand to its receptor activates intracellular Ras/ERK and PI3K signalling pathways. The roles of the product of jeb include embryonic visceral muscle development, growth and organ size regulation, retinal axon targeting, modulation of neuromuscular transmission as well as sleep regulation and olfactory learning.
   
  
 0.605
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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