| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Akh | AstA | FBpp0073069 | FBpp0084119 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Allatostatin-A; May act as a neurotransmitter or neuromodulator. | 0.890 |
| Akh | Burs | FBpp0073069 | FBpp0083529 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. | 0.793 |
| Akh | CCAP | FBpp0073069 | FBpp0083726 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. | 0.834 |
| Akh | ETH | FBpp0073069 | FBpp0072331 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Ecdysis triggering hormone (ETH) encodes two peptides (DrmETH1 and DrmETH2) involved in ecdysis. ETH depletion leads to respiratory and behavioral deficits, unsuccessful ecdysis and lethality. | 0.655 |
| Akh | Eh | FBpp0073069 | FBpp0082885 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Eclosion hormone (Eh) encodes a neurohormone involved in the control of ecdysis. At each ecdysis, the neurohormone is released into the hemolymph where it serves to potentiate the release of the product of ETH through a positive endocrine feedback loop. The product of Eh is also released into the nervous system where it contributes to turning on ecdysis. | 0.667 |
| Akh | Gpa2 | FBpp0073069 | FBpp0423268 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Glycoprotein hormone alpha 2 (Gpa2) encodes a protein that, when linked to the product of Gpb5, can activate the G protein-coupled receptor encoded by Lgr1. | 0.476 |
| Akh | Gpb5 | FBpp0073069 | FBpp0112499 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Glycoprotein hormone beta 5 (Gpb5) encodes a ligand of the G protein-coupled receptor encoded by Lgr1. It is involved in hormone-mediated signaling. | 0.557 |
| Akh | Pburs | FBpp0073069 | FBpp0080207 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Partner of Bursicon (Pburs) encodes a cystine knot protein that dimerizes with the product of Burs to form the bursicon neurohormone that acts on the receptor encoded by rk. Bursicon neurohormone is released after adult emergence and is required for tanning and hardening of the cuticle and expansion of the wings. | 0.472 |
| Akh | SIFa | FBpp0073069 | FBpp0293592 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Neuropeptide SIFamide; Ligand for the neuropeptide SIFamide receptor. Modulates sexual behavior by negatively regulating female receptivity to male courtship and by playing a role in male sex discrimination. Also involved in promoting sleep. Belongs to the FARP (FMRFamide related peptide) family. | 0.835 |
| Akh | rk | FBpp0073069 | FBpp0080183 | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | Rickets (rk) encodes a G-protein coupled receptor that signals intracellularly using the second messenger cAMP. It binds the heterodimeric hormone bursicon and is developmentally important for molting-related behaviors. It is also required after adult emergence for cuticle hardening and melanization. | 0.599 |
| AstA | Akh | FBpp0084119 | FBpp0073069 | Allatostatin-A; May act as a neurotransmitter or neuromodulator. | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | 0.890 |
| AstA | Burs | FBpp0084119 | FBpp0083529 | Allatostatin-A; May act as a neurotransmitter or neuromodulator. | Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. | 0.788 |
| AstA | CCAP | FBpp0084119 | FBpp0083726 | Allatostatin-A; May act as a neurotransmitter or neuromodulator. | Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions. | 0.829 |
| AstA | ETH | FBpp0084119 | FBpp0072331 | Allatostatin-A; May act as a neurotransmitter or neuromodulator. | Ecdysis triggering hormone (ETH) encodes two peptides (DrmETH1 and DrmETH2) involved in ecdysis. ETH depletion leads to respiratory and behavioral deficits, unsuccessful ecdysis and lethality. | 0.653 |
| AstA | Eh | FBpp0084119 | FBpp0082885 | Allatostatin-A; May act as a neurotransmitter or neuromodulator. | Eclosion hormone (Eh) encodes a neurohormone involved in the control of ecdysis. At each ecdysis, the neurohormone is released into the hemolymph where it serves to potentiate the release of the product of ETH through a positive endocrine feedback loop. The product of Eh is also released into the nervous system where it contributes to turning on ecdysis. | 0.654 |
| AstA | Gpa2 | FBpp0084119 | FBpp0423268 | Allatostatin-A; May act as a neurotransmitter or neuromodulator. | Glycoprotein hormone alpha 2 (Gpa2) encodes a protein that, when linked to the product of Gpb5, can activate the G protein-coupled receptor encoded by Lgr1. | 0.586 |
| AstA | Gpb5 | FBpp0084119 | FBpp0112499 | Allatostatin-A; May act as a neurotransmitter or neuromodulator. | Glycoprotein hormone beta 5 (Gpb5) encodes a ligand of the G protein-coupled receptor encoded by Lgr1. It is involved in hormone-mediated signaling. | 0.598 |
| AstA | SIFa | FBpp0084119 | FBpp0293592 | Allatostatin-A; May act as a neurotransmitter or neuromodulator. | Neuropeptide SIFamide; Ligand for the neuropeptide SIFamide receptor. Modulates sexual behavior by negatively regulating female receptivity to male courtship and by playing a role in male sex discrimination. Also involved in promoting sleep. Belongs to the FARP (FMRFamide related peptide) family. | 0.863 |
| AstA | rk | FBpp0084119 | FBpp0080183 | Allatostatin-A; May act as a neurotransmitter or neuromodulator. | Rickets (rk) encodes a G-protein coupled receptor that signals intracellularly using the second messenger cAMP. It binds the heterodimeric hormone bursicon and is developmentally important for molting-related behaviors. It is also required after adult emergence for cuticle hardening and melanization. | 0.429 |
| Burs | Akh | FBpp0083529 | FBpp0073069 | Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. | Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family. | 0.793 |
