node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atg7 | CG10254 | FBpp0085891 | FBpp0083868 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | Uncharacterized protein, isoform A; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process; protein monoubiquitination. | 0.601 |
Atg7 | CG40045 | FBpp0085891 | FBpp0110481 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | RE63412p; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein polyubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; Belongs to the ubiquitin-conjugating enzyme family. | 0.601 |
Atg7 | CG5823 | FBpp0085891 | FBpp0082929 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | HL05730p; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein ubiquitination; ubiquitin-dependent ERAD pathway; protein polyubiquitination. | 0.821 |
Atg7 | RpL40 | FBpp0085891 | FBpp0306837 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.786 |
Atg7 | Uba1 | FBpp0085891 | FBpp0087583 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family. | 0.857 |
Atg7 | Uba3 | FBpp0085891 | FBpp0086711 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | Nedd8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric Uba3-APP-BP1 E1 enzyme. E1 activates Nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a Nedd8-Uba3 thioester and free AMP. E1 finally transfers Nedd8 to the catalytic cysteine of UbcE2M. Required for Cul1 and Cul3 neddylation. Negatively regulates full-length ci stability and hedgehog signaling. | 0.706 |
Atg7 | Uba5 | FBpp0085891 | FBpp0073354 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | Ubiquitin-like activating enzyme 5 (Uba5) encodes a member of the E1-like ubiquitin-activating enzyme family. It activates the protein encoded by Ufm1, and acts as a key factor in the ufmylation process. It is involved in ATP binding, catalytic activity, cofactor binding, metal ion binding, nucleotide binding and oxidoreductase activity. | 0.733 |
Atg7 | Ubi-p5E | FBpp0085891 | FBpp0311816 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | Ubiquitin-5E, isoform A; Protein tag; ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; modification-dependent protein catabolic process; cellular protein modification process. | 0.611 |
Atg7 | Ubi-p63E | FBpp0085891 | FBpp0073035 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | Polyubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradatio [...] | 0.610 |
Atg7 | Uev1A | FBpp0085891 | FBpp0076859 | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | Ubiquitin-conjugating enzyme variant 1A (Uev1A) encodes a conserved protein that contributes to ubiquitin conjugating enzyme activity, but not catalytically, since it lacks the conserved cysteine residue essential for ubiquitin conjugation. It regulates genomic integrity, IMD pathway-mediated innate immunity, JNK-pathway mediated cell death and tumor invasion. | 0.574 |
CG10254 | Atg7 | FBpp0083868 | FBpp0085891 | Uncharacterized protein, isoform A; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process; protein monoubiquitination. | Autophagy-related 7 (Atg7) encodes an E1-type ligase for the autophagic ubiquitin-like proteins encoded by Atg8a and Atg12. Its roles include autophagosome formation, maintaining neuromuscular function and normal lifespan. | 0.601 |
CG10254 | CG40045 | FBpp0083868 | FBpp0110481 | Uncharacterized protein, isoform A; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process; protein monoubiquitination. | RE63412p; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein polyubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; Belongs to the ubiquitin-conjugating enzyme family. | 0.606 |
CG10254 | CG5823 | FBpp0083868 | FBpp0082929 | Uncharacterized protein, isoform A; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process; protein monoubiquitination. | HL05730p; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein ubiquitination; ubiquitin-dependent ERAD pathway; protein polyubiquitination. | 0.662 |
CG10254 | RpL40 | FBpp0083868 | FBpp0306837 | Uncharacterized protein, isoform A; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process; protein monoubiquitination. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.742 |
CG10254 | Uba1 | FBpp0083868 | FBpp0087583 | Uncharacterized protein, isoform A; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process; protein monoubiquitination. | Ubiquitin activating enzyme 1 (Uba1) encodes an E1 enzyme involved in protein ubiquitylation. It contributes to multiple processes including regulation of Ras-ERK signaling, autophagy, apoptosis and tissue growth; Belongs to the ubiquitin-activating E1 family. | 0.776 |
CG10254 | Uba3 | FBpp0083868 | FBpp0086711 | Uncharacterized protein, isoform A; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process; protein monoubiquitination. | Nedd8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric Uba3-APP-BP1 E1 enzyme. E1 activates Nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a Nedd8-Uba3 thioester and free AMP. E1 finally transfers Nedd8 to the catalytic cysteine of UbcE2M. Required for Cul1 and Cul3 neddylation. Negatively regulates full-length ci stability and hedgehog signaling. | 0.619 |
CG10254 | Uba5 | FBpp0083868 | FBpp0073354 | Uncharacterized protein, isoform A; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process; protein monoubiquitination. | Ubiquitin-like activating enzyme 5 (Uba5) encodes a member of the E1-like ubiquitin-activating enzyme family. It activates the protein encoded by Ufm1, and acts as a key factor in the ufmylation process. It is involved in ATP binding, catalytic activity, cofactor binding, metal ion binding, nucleotide binding and oxidoreductase activity. | 0.615 |
CG10254 | Ubi-p5E | FBpp0083868 | FBpp0311816 | Uncharacterized protein, isoform A; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process; protein monoubiquitination. | Ubiquitin-5E, isoform A; Protein tag; ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; modification-dependent protein catabolic process; cellular protein modification process. | 0.659 |
CG10254 | Ubi-p63E | FBpp0083868 | FBpp0073035 | Uncharacterized protein, isoform A; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process; protein monoubiquitination. | Polyubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradatio [...] | 0.655 |
CG10254 | Uev1A | FBpp0083868 | FBpp0076859 | Uncharacterized protein, isoform A; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process; protein monoubiquitination. | Ubiquitin-conjugating enzyme variant 1A (Uev1A) encodes a conserved protein that contributes to ubiquitin conjugating enzyme activity, but not catalytically, since it lacks the conserved cysteine residue essential for ubiquitin conjugation. It regulates genomic integrity, IMD pathway-mediated innate immunity, JNK-pathway mediated cell death and tumor invasion. | 0.725 |