node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG13599 | CG6425 | FBpp0083881 | FBpp0084419 | RE56765p; It is involved in the biological process described with: regulation of exit from mitosis. | LD14717p. | 0.444 |
CG13599 | Nuf2 | FBpp0083881 | FBpp0079052 | RE56765p; It is involved in the biological process described with: regulation of exit from mitosis. | Nuf2 (Nuf2) encodes a protein involved in mitotic metaphase plate congression. | 0.507 |
CG13599 | Sep5 | FBpp0083881 | FBpp0087952 | RE56765p; It is involved in the biological process described with: regulation of exit from mitosis. | Septin 5 (Sep5) encodes a member of the septin family of GTP-binding proteins. Septins form hetero-oligomeric filaments and rings that have roles in cytokinesis, cell polarity and membrane rigidity. Sep5 is not essential for development, but mutants display a synthetic lethal pupal phenotype when combined with mutations in its paralog Sep2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | 0.412 |
CG13599 | Spc25 | FBpp0083881 | FBpp0082158 | RE56765p; It is involved in the biological process described with: regulation of exit from mitosis. | Kinetochore protein Spc25; Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing [...] | 0.620 |
CG13599 | mad2 | FBpp0083881 | FBpp0076819 | RE56765p; It is involved in the biological process described with: regulation of exit from mitosis. | RE72064p; Mad2 (mad2) encodes a conserved component of the spindle checkpoint. During mitosis, it is recruited to unattached kinetochores, where it binds the products of Mad1 and fzy, promoting the assembly of the mitotic checkpoint complex. During interphase, the product of mad2 is intranuclear, bound to the product of Mad1, and associated primarily with the nuclear pore complex. | 0.537 |
CG13599 | zuc | FBpp0083881 | FBpp0079900 | RE56765p; It is involved in the biological process described with: regulation of exit from mitosis. | Mitochondrial cardiolipin hydrolase; Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes compose [...] | 0.467 |
CG6425 | CG13599 | FBpp0084419 | FBpp0083881 | LD14717p. | RE56765p; It is involved in the biological process described with: regulation of exit from mitosis. | 0.444 |
CG6425 | zuc | FBpp0084419 | FBpp0079900 | LD14717p. | Mitochondrial cardiolipin hydrolase; Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes compose [...] | 0.450 |
Nuf2 | CG13599 | FBpp0079052 | FBpp0083881 | Nuf2 (Nuf2) encodes a protein involved in mitotic metaphase plate congression. | RE56765p; It is involved in the biological process described with: regulation of exit from mitosis. | 0.507 |
Nuf2 | Spc25 | FBpp0079052 | FBpp0082158 | Nuf2 (Nuf2) encodes a protein involved in mitotic metaphase plate congression. | Kinetochore protein Spc25; Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing [...] | 0.999 |
Nuf2 | mad2 | FBpp0079052 | FBpp0076819 | Nuf2 (Nuf2) encodes a protein involved in mitotic metaphase plate congression. | RE72064p; Mad2 (mad2) encodes a conserved component of the spindle checkpoint. During mitosis, it is recruited to unattached kinetochores, where it binds the products of Mad1 and fzy, promoting the assembly of the mitotic checkpoint complex. During interphase, the product of mad2 is intranuclear, bound to the product of Mad1, and associated primarily with the nuclear pore complex. | 0.862 |
Sep5 | CG13599 | FBpp0087952 | FBpp0083881 | Septin 5 (Sep5) encodes a member of the septin family of GTP-binding proteins. Septins form hetero-oligomeric filaments and rings that have roles in cytokinesis, cell polarity and membrane rigidity. Sep5 is not essential for development, but mutants display a synthetic lethal pupal phenotype when combined with mutations in its paralog Sep2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | RE56765p; It is involved in the biological process described with: regulation of exit from mitosis. | 0.412 |
Spc25 | CG13599 | FBpp0082158 | FBpp0083881 | Kinetochore protein Spc25; Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing [...] | RE56765p; It is involved in the biological process described with: regulation of exit from mitosis. | 0.620 |
Spc25 | Nuf2 | FBpp0082158 | FBpp0079052 | Kinetochore protein Spc25; Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing [...] | Nuf2 (Nuf2) encodes a protein involved in mitotic metaphase plate congression. | 0.999 |
Spc25 | mad2 | FBpp0082158 | FBpp0076819 | Kinetochore protein Spc25; Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing [...] | RE72064p; Mad2 (mad2) encodes a conserved component of the spindle checkpoint. During mitosis, it is recruited to unattached kinetochores, where it binds the products of Mad1 and fzy, promoting the assembly of the mitotic checkpoint complex. During interphase, the product of mad2 is intranuclear, bound to the product of Mad1, and associated primarily with the nuclear pore complex. | 0.808 |
Spc25 | zuc | FBpp0082158 | FBpp0079900 | Kinetochore protein Spc25; Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing [...] | Mitochondrial cardiolipin hydrolase; Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes compose [...] | 0.454 |
mad2 | CG13599 | FBpp0076819 | FBpp0083881 | RE72064p; Mad2 (mad2) encodes a conserved component of the spindle checkpoint. During mitosis, it is recruited to unattached kinetochores, where it binds the products of Mad1 and fzy, promoting the assembly of the mitotic checkpoint complex. During interphase, the product of mad2 is intranuclear, bound to the product of Mad1, and associated primarily with the nuclear pore complex. | RE56765p; It is involved in the biological process described with: regulation of exit from mitosis. | 0.537 |
mad2 | Nuf2 | FBpp0076819 | FBpp0079052 | RE72064p; Mad2 (mad2) encodes a conserved component of the spindle checkpoint. During mitosis, it is recruited to unattached kinetochores, where it binds the products of Mad1 and fzy, promoting the assembly of the mitotic checkpoint complex. During interphase, the product of mad2 is intranuclear, bound to the product of Mad1, and associated primarily with the nuclear pore complex. | Nuf2 (Nuf2) encodes a protein involved in mitotic metaphase plate congression. | 0.862 |
mad2 | Spc25 | FBpp0076819 | FBpp0082158 | RE72064p; Mad2 (mad2) encodes a conserved component of the spindle checkpoint. During mitosis, it is recruited to unattached kinetochores, where it binds the products of Mad1 and fzy, promoting the assembly of the mitotic checkpoint complex. During interphase, the product of mad2 is intranuclear, bound to the product of Mad1, and associated primarily with the nuclear pore complex. | Kinetochore protein Spc25; Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing [...] | 0.808 |
zuc | CG13599 | FBpp0079900 | FBpp0083881 | Mitochondrial cardiolipin hydrolase; Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes compose [...] | RE56765p; It is involved in the biological process described with: regulation of exit from mitosis. | 0.467 |