node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Chmp1 | Ist1 | FBpp0311533 | FBpp0076658 | Charged multivesicular body protein 1 (Chmp1) encodes a component of ESCRT-III, a conserved protein complex that mediates downregulation of activated transmembrane receptors through formation of the multivesicular body from the endosome. It binds to the product of Vps4, promoting the dissociation and recycling of ESCRT-III components to the cytoplasm. | LD14015p; It is involved in the biological process described with: protein transport; endosome transport via multivesicular body sorting pathway; protein localization. | 0.999 |
Chmp1 | Vps24 | FBpp0311533 | FBpp0312584 | Charged multivesicular body protein 1 (Chmp1) encodes a component of ESCRT-III, a conserved protein complex that mediates downregulation of activated transmembrane receptors through formation of the multivesicular body from the endosome. It binds to the product of Vps4, promoting the dissociation and recycling of ESCRT-III components to the cytoplasm. | Vacuolar protein sorting 24 (Vps24) encodes an essential subunit of ESCRT-III, one of the endosomal sorting complexes required for transport (ESCRT). It is involved in membrane remodeling in diverse cellular processes, such as multi-vesicular body biogenesis, cytokinesis and virus budding. | 0.998 |
Chmp1 | spas | FBpp0311533 | FBpp0083918 | Charged multivesicular body protein 1 (Chmp1) encodes a component of ESCRT-III, a conserved protein complex that mediates downregulation of activated transmembrane receptors through formation of the multivesicular body from the endosome. It binds to the product of Vps4, promoting the dissociation and recycling of ESCRT-III components to the cytoplasm. | Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. | 0.833 |
Ist1 | Chmp1 | FBpp0076658 | FBpp0311533 | LD14015p; It is involved in the biological process described with: protein transport; endosome transport via multivesicular body sorting pathway; protein localization. | Charged multivesicular body protein 1 (Chmp1) encodes a component of ESCRT-III, a conserved protein complex that mediates downregulation of activated transmembrane receptors through formation of the multivesicular body from the endosome. It binds to the product of Vps4, promoting the dissociation and recycling of ESCRT-III components to the cytoplasm. | 0.999 |
Ist1 | ReepA | FBpp0076658 | FBpp0291910 | LD14015p; It is involved in the biological process described with: protein transport; endosome transport via multivesicular body sorting pathway; protein localization. | Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. | 0.668 |
Ist1 | Seipin | FBpp0076658 | FBpp0070426 | LD14015p; It is involved in the biological process described with: protein transport; endosome transport via multivesicular body sorting pathway; protein localization. | Seipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis. | 0.412 |
Ist1 | Vps24 | FBpp0076658 | FBpp0312584 | LD14015p; It is involved in the biological process described with: protein transport; endosome transport via multivesicular body sorting pathway; protein localization. | Vacuolar protein sorting 24 (Vps24) encodes an essential subunit of ESCRT-III, one of the endosomal sorting complexes required for transport (ESCRT). It is involved in membrane remodeling in diverse cellular processes, such as multi-vesicular body biogenesis, cytokinesis and virus budding. | 0.982 |
Ist1 | spartin | FBpp0076658 | FBpp0078501 | LD14015p; It is involved in the biological process described with: protein transport; endosome transport via multivesicular body sorting pathway; protein localization. | Protein spartin; During postembryonic development, functions with endocytic adapter Eps-15 in neurons to restrain synaptic growth, by inhibiting BMP signaling, and to control synaptic endocytosis. Required presynaptically for neuromuscular junction (NMJ) neurotransmission. Inhibits neuronal BMP signaling by promoting endocytic internalization and subsequent endosomal trafficking of the BMP receptor wit. In this way, regulates the Fmr1 translational regulator controlling Futsch expression to modulate neuronal microtubule stability, which controls both synaptogenesis and neuronal survival. | 0.937 |
Ist1 | spas | FBpp0076658 | FBpp0083918 | LD14015p; It is involved in the biological process described with: protein transport; endosome transport via multivesicular body sorting pathway; protein localization. | Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. | 0.994 |
Patronin | kat80 | FBpp0304550 | FBpp0074026 | Patronin; Involved in mitotic spindle assembly. Regulates microtubule (MT) severing. Antagonizes the activity of the kinesin-13 depolymerase Klp10A thereby switching off the depolymerization of the MTs at their pole-associated minus ends, which turns off poleward flux and induces anaphase B spindle elongation. Involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Klp98A targets Sara-expressing endosomes to the central spindle which is s [...] | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. | 0.744 |
Patronin | spas | FBpp0304550 | FBpp0083918 | Patronin; Involved in mitotic spindle assembly. Regulates microtubule (MT) severing. Antagonizes the activity of the kinesin-13 depolymerase Klp10A thereby switching off the depolymerization of the MTs at their pole-associated minus ends, which turns off poleward flux and induces anaphase B spindle elongation. Involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Klp98A targets Sara-expressing endosomes to the central spindle which is s [...] | Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. | 0.746 |
ReepA | Ist1 | FBpp0291910 | FBpp0076658 | Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. | LD14015p; It is involved in the biological process described with: protein transport; endosome transport via multivesicular body sorting pathway; protein localization. | 0.668 |
ReepA | Rtnl1 | FBpp0291910 | FBpp0290753 | Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. | 0.733 |
ReepA | Seipin | FBpp0291910 | FBpp0070426 | Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. | Seipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis. | 0.845 |
ReepA | atl | FBpp0291910 | FBpp0084037 | Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. | Atlastin; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate microtubule polymerization and Golgi biogenesis. Required for dopaminergic neurons survival and the growth of muscles and synapses at neuromuscular junctions. | 0.958 |
ReepA | spartin | FBpp0291910 | FBpp0078501 | Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. | Protein spartin; During postembryonic development, functions with endocytic adapter Eps-15 in neurons to restrain synaptic growth, by inhibiting BMP signaling, and to control synaptic endocytosis. Required presynaptically for neuromuscular junction (NMJ) neurotransmission. Inhibits neuronal BMP signaling by promoting endocytic internalization and subsequent endosomal trafficking of the BMP receptor wit. In this way, regulates the Fmr1 translational regulator controlling Futsch expression to modulate neuronal microtubule stability, which controls both synaptogenesis and neuronal survival. | 0.844 |
ReepA | spas | FBpp0291910 | FBpp0083918 | Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. | Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. | 0.922 |
Rtnl1 | ReepA | FBpp0290753 | FBpp0291910 | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. | Receptor expression enhancing protein A (ReepA) encodes a member of the DP1/Yop1p family. It localizes to the endoplasmic reticulum (ER) and is involved in the prevention of ER-stress. | 0.733 |
Rtnl1 | Seipin | FBpp0290753 | FBpp0070426 | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. | Seipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis. | 0.636 |
Rtnl1 | atl | FBpp0290753 | FBpp0084037 | Reticulon-like1 (Rtnl1) encodes a reticulon family member, with predicted intramembrane hairpin domains that can insert into the cytosolic face of the endoplasmic reticulum (ER), thereby curving it and promoting ER tubule formation. It is enriched on tubular ER, including axons and egg chamber fusomes. | Atlastin; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate microtubule polymerization and Golgi biogenesis. Required for dopaminergic neurons survival and the growth of muscles and synapses at neuromuscular junctions. | 0.902 |