node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdc37 | Gp93 | FBpp0072660 | FBpp0084623 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis. Belongs to the CDC37 family. | Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. | 0.999 |
Cdc37 | Hsp83 | FBpp0072660 | FBpp0305095 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis. Belongs to the CDC37 family. | Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] | 0.993 |
Cdc37 | PpD3 | FBpp0072660 | FBpp0081606 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis. Belongs to the CDC37 family. | Protein phosphatase D3 (PpD3) encodes a protein required for mitosis. | 0.966 |
Cdc37 | Sgt1 | FBpp0072660 | FBpp0081351 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis. Belongs to the CDC37 family. | suppressor-of-G2-allele-of-skp1 (Sgt1) encodes a protein required for the stability of the kinase encoded by polo and has a role in centrosome maturation and function. | 0.714 |
Cdc37 | Trap1 | FBpp0072660 | FBpp0085482 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis. Belongs to the CDC37 family. | Trap1, isoform A; Trap1 (Trap1) encodes a mitochondrial chaperone protein of the heat shock protein (HSP90) family. It shows an ATPase activity and is involved in neurodegeneration associated with mitochondrial dysfunction. | 0.929 |
Cdc37 | Tsc1 | FBpp0072660 | FBpp0083931 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis. Belongs to the CDC37 family. | LD23779p; Tsc1 (Tsc1) encodes a tumour suppressor protein that forms a complex with the product of gig. They control cellular growth via antagonizing insulin and TOR signalling pathways. | 0.857 |
Cdc37 | mora | FBpp0072660 | FBpp0083939 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis. Belongs to the CDC37 family. | Cysteine and histidine-rich domain-containing protein; Morgana (mora) encodes an evolutionarily conserved co-chaperone of the product of Hsp83 that controls neuronal cell growth in the context of dendrite remodeling. Dendritic growth and branching are controlled by at least partly separate mechanisms. The Insulin/IGF signaling (IIS)/TORC1 pathways control both growth and branching to avert underdevelopment, whereas the products of mora and rictor realize proportional scaling of the entire arbor. | 0.683 |
Cdc37 | p23 | FBpp0072660 | FBpp0081560 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis. Belongs to the CDC37 family. | Uncharacterized protein CG16817; prostaglandin-E synthase activity; Hsp90 protein binding; chaperone binding. It is involved in the biological process described with: protein folding; positive regulation of small RNA loading onto RISC; chaperone-mediated protein complex assembly; Belongs to the p23/wos2 family. | 0.760 |
Cdc37 | spag | FBpp0072660 | FBpp0072164 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis. Belongs to the CDC37 family. | FI17138p1; Spaghetti (spag) encodes a TPR domain-containing co-chaperone that associates with Hsp70 and Hsp90 to regulate their activity in macromolecular complexes like RNA polymerase, ribonucleoproteins and Phosphatidyl-Inositol 3-kinase-related kinases. It has been shown to regulate the product of dco levels, with consequences for circadian rhythms and apoptosis. | 0.518 |
Gp93 | Cdc37 | FBpp0084623 | FBpp0072660 | Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis. Belongs to the CDC37 family. | 0.999 |
Gp93 | Hsp83 | FBpp0084623 | FBpp0305095 | Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. | Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] | 0.468 |
Gp93 | PpD3 | FBpp0084623 | FBpp0081606 | Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. | Protein phosphatase D3 (PpD3) encodes a protein required for mitosis. | 0.949 |
Gp93 | Sgt1 | FBpp0084623 | FBpp0081351 | Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. | suppressor-of-G2-allele-of-skp1 (Sgt1) encodes a protein required for the stability of the kinase encoded by polo and has a role in centrosome maturation and function. | 0.948 |
Gp93 | Trap1 | FBpp0084623 | FBpp0085482 | Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. | Trap1, isoform A; Trap1 (Trap1) encodes a mitochondrial chaperone protein of the heat shock protein (HSP90) family. It shows an ATPase activity and is involved in neurodegeneration associated with mitochondrial dysfunction. | 0.425 |
Gp93 | mora | FBpp0084623 | FBpp0083939 | Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. | Cysteine and histidine-rich domain-containing protein; Morgana (mora) encodes an evolutionarily conserved co-chaperone of the product of Hsp83 that controls neuronal cell growth in the context of dendrite remodeling. Dendritic growth and branching are controlled by at least partly separate mechanisms. The Insulin/IGF signaling (IIS)/TORC1 pathways control both growth and branching to avert underdevelopment, whereas the products of mora and rictor realize proportional scaling of the entire arbor. | 0.929 |
Gp93 | nudC | FBpp0084623 | FBpp0297079 | Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. | Nuclear migration protein NudC; nudC (nudC) encodes a component of a specialized dynein complex involved in nucleus localization and positive regulation of dendrite morphogenesis. | 0.419 |
Gp93 | p23 | FBpp0084623 | FBpp0081560 | Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. | Uncharacterized protein CG16817; prostaglandin-E synthase activity; Hsp90 protein binding; chaperone binding. It is involved in the biological process described with: protein folding; positive regulation of small RNA loading onto RISC; chaperone-mediated protein complex assembly; Belongs to the p23/wos2 family. | 0.908 |
Gp93 | spag | FBpp0084623 | FBpp0072164 | Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. | FI17138p1; Spaghetti (spag) encodes a TPR domain-containing co-chaperone that associates with Hsp70 and Hsp90 to regulate their activity in macromolecular complexes like RNA polymerase, ribonucleoproteins and Phosphatidyl-Inositol 3-kinase-related kinases. It has been shown to regulate the product of dco levels, with consequences for circadian rhythms and apoptosis. | 0.876 |
Hsp83 | Cdc37 | FBpp0305095 | FBpp0072660 | Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis. Belongs to the CDC37 family. | 0.993 |
Hsp83 | Gp93 | FBpp0305095 | FBpp0084623 | Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] | Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development. | 0.468 |