node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ChAT | mAChR-A | FBpp0088397 | FBpp0072275 | Choline O-acetyltransferase 13 kDa chain; Choline acetyltransferase (ChAT) encodes a protein that catalyzes the biosynthesis of the neurotransmitter acetylcholine. It is considered to be a specific marker for cholinergic neurons. | Muscarinic acetylcholine receptor DM1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. May have a role in the processing of olfactory and mechanosensory signals; regulation of neurosecretion. | 0.568 |
ChAT | nAChRalpha2 | FBpp0088397 | FBpp0084023 | Choline O-acetyltransferase 13 kDa chain; Choline acetyltransferase (ChAT) encodes a protein that catalyzes the biosynthesis of the neurotransmitter acetylcholine. It is considered to be a specific marker for cholinergic neurons. | Acetylcholine receptor subunit alpha-like 2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. | 0.530 |
ChAT | nAChRbeta2 | FBpp0088397 | FBpp0084061 | Choline O-acetyltransferase 13 kDa chain; Choline acetyltransferase (ChAT) encodes a protein that catalyzes the biosynthesis of the neurotransmitter acetylcholine. It is considered to be a specific marker for cholinergic neurons. | Nicotinic Acetylcholine Receptor beta2 (nAChRbeta2) encodes a subunit of the nicotinic acetylcholine receptor, which is part of the superfamily of ligand-gated ion channels. These channels open to facilitate the passage of cations across synaptic membranes in response to the binding of their native ligand, acetylcholine. Mutations in nAChRbeta2 have been associated with resistance phenotypes to several neonicotinoid insecticides. | 0.466 |
Lcch3 | mAChR-A | FBpp0089263 | FBpp0072275 | Gamma-aminobutyric acid receptor subunit beta-like; GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. Combines with the ligand-gated ion channel subunit GRD to form cation-selective GABA-gated ion channels when coexpressed in Xenopus laevis oocytes. | Muscarinic acetylcholine receptor DM1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. May have a role in the processing of olfactory and mechanosensory signals; regulation of neurosecretion. | 0.420 |
Lcch3 | nAChRalpha2 | FBpp0089263 | FBpp0084023 | Gamma-aminobutyric acid receptor subunit beta-like; GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. Combines with the ligand-gated ion channel subunit GRD to form cation-selective GABA-gated ion channels when coexpressed in Xenopus laevis oocytes. | Acetylcholine receptor subunit alpha-like 2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. | 0.464 |
Lcch3 | nAChRalpha6 | FBpp0089263 | FBpp0079502 | Gamma-aminobutyric acid receptor subunit beta-like; GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. Combines with the ligand-gated ion channel subunit GRD to form cation-selective GABA-gated ion channels when coexpressed in Xenopus laevis oocytes. | Nicotinic Acetylcholine Receptor alpha6 (nAChRalpha6) encodes a postsynaptic receptor involved in cation transport, synaptic transmission, muscle homeostasis and sensitivity to insecticides. | 0.429 |
Lcch3 | nAChRalpha7 | FBpp0089263 | FBpp0291049 | Gamma-aminobutyric acid receptor subunit beta-like; GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. Combines with the ligand-gated ion channel subunit GRD to form cation-selective GABA-gated ion channels when coexpressed in Xenopus laevis oocytes. | Nicotinic Acetylcholine Receptor alpha7 (nAChRalpha7) encodes a subunit of the nicotinic acetylcholine receptor, a pentameric neurotransmitter-gated ion channel. | 0.511 |
Lcch3 | nAChRbeta2 | FBpp0089263 | FBpp0084061 | Gamma-aminobutyric acid receptor subunit beta-like; GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. Combines with the ligand-gated ion channel subunit GRD to form cation-selective GABA-gated ion channels when coexpressed in Xenopus laevis oocytes. | Nicotinic Acetylcholine Receptor beta2 (nAChRbeta2) encodes a subunit of the nicotinic acetylcholine receptor, which is part of the superfamily of ligand-gated ion channels. These channels open to facilitate the passage of cations across synaptic membranes in response to the binding of their native ligand, acetylcholine. Mutations in nAChRbeta2 have been associated with resistance phenotypes to several neonicotinoid insecticides. | 0.467 |
RIC-3 | nAChRalpha2 | FBpp0071457 | FBpp0084023 | RIC3 acetylcholine receptor chaperone (RIC-3) encodes a protein that assists with nicotinic acetylcholine receptor protein folding. | Acetylcholine receptor subunit alpha-like 2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. | 0.706 |
RIC-3 | nAChRalpha5 | FBpp0071457 | FBpp0423154 | RIC3 acetylcholine receptor chaperone (RIC-3) encodes a protein that assists with nicotinic acetylcholine receptor protein folding. | Nicotinic Acetylcholine Receptor alpha5 (nAChRalpha5) encodes a subunit of the nicotinic acetylcholine receptor, which is a pentameric neurotransmitter-gated ion channel. | 0.837 |
RIC-3 | nAChRalpha6 | FBpp0071457 | FBpp0079502 | RIC3 acetylcholine receptor chaperone (RIC-3) encodes a protein that assists with nicotinic acetylcholine receptor protein folding. | Nicotinic Acetylcholine Receptor alpha6 (nAChRalpha6) encodes a postsynaptic receptor involved in cation transport, synaptic transmission, muscle homeostasis and sensitivity to insecticides. | 0.846 |
RIC-3 | nAChRalpha7 | FBpp0071457 | FBpp0291049 | RIC3 acetylcholine receptor chaperone (RIC-3) encodes a protein that assists with nicotinic acetylcholine receptor protein folding. | Nicotinic Acetylcholine Receptor alpha7 (nAChRalpha7) encodes a subunit of the nicotinic acetylcholine receptor, a pentameric neurotransmitter-gated ion channel. | 0.839 |
RIC-3 | nAChRbeta1 | FBpp0071457 | FBpp0073155 | RIC3 acetylcholine receptor chaperone (RIC-3) encodes a protein that assists with nicotinic acetylcholine receptor protein folding. | Acetylcholine receptor subunit beta-like 1; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. | 0.641 |
RIC-3 | nAChRbeta2 | FBpp0071457 | FBpp0084061 | RIC3 acetylcholine receptor chaperone (RIC-3) encodes a protein that assists with nicotinic acetylcholine receptor protein folding. | Nicotinic Acetylcholine Receptor beta2 (nAChRbeta2) encodes a subunit of the nicotinic acetylcholine receptor, which is part of the superfamily of ligand-gated ion channels. These channels open to facilitate the passage of cations across synaptic membranes in response to the binding of their native ligand, acetylcholine. Mutations in nAChRbeta2 have been associated with resistance phenotypes to several neonicotinoid insecticides. | 0.663 |
mAChR-A | ChAT | FBpp0072275 | FBpp0088397 | Muscarinic acetylcholine receptor DM1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. May have a role in the processing of olfactory and mechanosensory signals; regulation of neurosecretion. | Choline O-acetyltransferase 13 kDa chain; Choline acetyltransferase (ChAT) encodes a protein that catalyzes the biosynthesis of the neurotransmitter acetylcholine. It is considered to be a specific marker for cholinergic neurons. | 0.568 |
mAChR-A | Lcch3 | FBpp0072275 | FBpp0089263 | Muscarinic acetylcholine receptor DM1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. May have a role in the processing of olfactory and mechanosensory signals; regulation of neurosecretion. | Gamma-aminobutyric acid receptor subunit beta-like; GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. Combines with the ligand-gated ion channel subunit GRD to form cation-selective GABA-gated ion channels when coexpressed in Xenopus laevis oocytes. | 0.420 |
mAChR-A | nAChRalpha5 | FBpp0072275 | FBpp0423154 | Muscarinic acetylcholine receptor DM1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. May have a role in the processing of olfactory and mechanosensory signals; regulation of neurosecretion. | Nicotinic Acetylcholine Receptor alpha5 (nAChRalpha5) encodes a subunit of the nicotinic acetylcholine receptor, which is a pentameric neurotransmitter-gated ion channel. | 0.469 |
mAChR-A | nAChRalpha7 | FBpp0072275 | FBpp0291049 | Muscarinic acetylcholine receptor DM1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. May have a role in the processing of olfactory and mechanosensory signals; regulation of neurosecretion. | Nicotinic Acetylcholine Receptor alpha7 (nAChRalpha7) encodes a subunit of the nicotinic acetylcholine receptor, a pentameric neurotransmitter-gated ion channel. | 0.651 |
mAChR-A | nAChRbeta1 | FBpp0072275 | FBpp0073155 | Muscarinic acetylcholine receptor DM1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. May have a role in the processing of olfactory and mechanosensory signals; regulation of neurosecretion. | Acetylcholine receptor subunit beta-like 1; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. | 0.429 |
mAChR-A | nAChRbeta2 | FBpp0072275 | FBpp0084061 | Muscarinic acetylcholine receptor DM1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. May have a role in the processing of olfactory and mechanosensory signals; regulation of neurosecretion. | Nicotinic Acetylcholine Receptor beta2 (nAChRbeta2) encodes a subunit of the nicotinic acetylcholine receptor, which is part of the superfamily of ligand-gated ion channels. These channels open to facilitate the passage of cations across synaptic membranes in response to the binding of their native ligand, acetylcholine. Mutations in nAChRbeta2 have been associated with resistance phenotypes to several neonicotinoid insecticides. | 0.507 |