Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Actbeta | cv-2 | FBpp0088273 | FBpp0071536 | Inhibin beta chain; Controls several aspects of neuronal morphogenesis; essential for optic lobe development, EcR-B1 expression in larval brains, mushroom body remodeling, dorsal neuron morphogenesis and motoneuron axon guidance. Ligands Actbeta and daw act redundantly through the Activin receptor Babo and its transcriptional mediator Smad2 (Smox), to regulate neuroblast numbers and proliferation rates in the developing larval brain; Belongs to the TGF-beta family. | Crossveinless 2 (cv-2) encodes a secreted protein that binds BMPs, the BMP receptor encoded by tkv and Heparan Sulfate Proteoglycans. It either promotes BMP signaling, as in the developing crossveins, or inhibits BMP signaling, as in the early embryo. | 0.422 |
| Actbeta | phtf | FBpp0088273 | FBpp0085459 | Inhibin beta chain; Controls several aspects of neuronal morphogenesis; essential for optic lobe development, EcR-B1 expression in larval brains, mushroom body remodeling, dorsal neuron morphogenesis and motoneuron axon guidance. Ligands Actbeta and daw act redundantly through the Activin receptor Babo and its transcriptional mediator Smad2 (Smox), to regulate neuroblast numbers and proliferation rates in the developing larval brain; Belongs to the TGF-beta family. | Putative homeodomain transcription factor; May play a role in transcription regulation. | 0.441 |
| Actbeta | tld | FBpp0088273 | FBpp0084070 | Inhibin beta chain; Controls several aspects of neuronal morphogenesis; essential for optic lobe development, EcR-B1 expression in larval brains, mushroom body remodeling, dorsal neuron morphogenesis and motoneuron axon guidance. Ligands Actbeta and daw act redundantly through the Activin receptor Babo and its transcriptional mediator Smad2 (Smox), to regulate neuroblast numbers and proliferation rates in the developing larval brain; Belongs to the TGF-beta family. | Dorsal-ventral patterning protein tolloid; Tolloid (tld) encodes a member of the asticin metalloprotease family. Its primary function is to cleave the product of sog, which facilitates the diffusion of the ligand encoded by dpp to the dorsal-most cells in the early blastoderm embryo, helping to specify formation of the amnioserosa. | 0.601 |
| Actbeta | tok | FBpp0088273 | FBpp0084069 | Inhibin beta chain; Controls several aspects of neuronal morphogenesis; essential for optic lobe development, EcR-B1 expression in larval brains, mushroom body remodeling, dorsal neuron morphogenesis and motoneuron axon guidance. Ligands Actbeta and daw act redundantly through the Activin receptor Babo and its transcriptional mediator Smad2 (Smox), to regulate neuroblast numbers and proliferation rates in the developing larval brain; Belongs to the TGF-beta family. | Metalloendopeptidase; Tolkin (tok) encodes a Zinc metallopeptidase with similar substrate specificity to the product of tld, which is its paralog. It cleaves the product of sog as well as the prodomains of several TGF-beta ligands. | 0.519 |
| CG31279 | tld | FBpp0290648 | FBpp0084070 | Uncharacterized protein, isoform B. | Dorsal-ventral patterning protein tolloid; Tolloid (tld) encodes a member of the asticin metalloprotease family. Its primary function is to cleave the product of sog, which facilitates the diffusion of the ligand encoded by dpp to the dorsal-most cells in the early blastoderm embryo, helping to specify formation of the amnioserosa. | 0.670 |
| CG31279 | tok | FBpp0290648 | FBpp0084069 | Uncharacterized protein, isoform B. | Metalloendopeptidase; Tolkin (tok) encodes a Zinc metallopeptidase with similar substrate specificity to the product of tld, which is its paralog. It cleaves the product of sog as well as the prodomains of several TGF-beta ligands. | 0.793 |
| Iml1 | RhoGEF2 | FBpp0072587 | FBpp0086124 | GATOR complex protein Iml1; An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or [...] | Rho guanine nucleotide exchange factor 2 (RhoGEF2) encodes a protein involved in actin organization and contractility. It contributes to multiple actin-based processes including wound healing, cell shape and cell contraction. | 0.499 |
| Iml1 | mbc | FBpp0072587 | FBpp0293271 | GATOR complex protein Iml1; An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or [...] | Myoblast city (mbc) encodes an unconventional bipartite GEF that, in combination with the product of Ced-12, activates the monomeric GTPase encoded by Rac1. It contributes to myoblast fusion, border cell migration and dorsal closure; Belongs to the DOCK family. | 0.504 |
| Iml1 | tok | FBpp0072587 | FBpp0084069 | GATOR complex protein Iml1; An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or [...] | Metalloendopeptidase; Tolkin (tok) encodes a Zinc metallopeptidase with similar substrate specificity to the product of tld, which is its paralog. It cleaves the product of sog as well as the prodomains of several TGF-beta ligands. | 0.536 |
| Loxl1 | tld | FBpp0085171 | FBpp0084070 | Lysyl oxidase-like 1 (Loxl1) encodes a protein-lysine 6-oxidase that might be involved in euchromatinization and gene regulation. | Dorsal-ventral patterning protein tolloid; Tolloid (tld) encodes a member of the asticin metalloprotease family. Its primary function is to cleave the product of sog, which facilitates the diffusion of the ligand encoded by dpp to the dorsal-most cells in the early blastoderm embryo, helping to specify formation of the amnioserosa. | 0.540 |
| Loxl1 | tok | FBpp0085171 | FBpp0084069 | Lysyl oxidase-like 1 (Loxl1) encodes a protein-lysine 6-oxidase that might be involved in euchromatinization and gene regulation. | Metalloendopeptidase; Tolkin (tok) encodes a Zinc metallopeptidase with similar substrate specificity to the product of tld, which is its paralog. It cleaves the product of sog as well as the prodomains of several TGF-beta ligands. | 0.540 |
| RhoGEF2 | Iml1 | FBpp0086124 | FBpp0072587 | Rho guanine nucleotide exchange factor 2 (RhoGEF2) encodes a protein involved in actin organization and contractility. It contributes to multiple actin-based processes including wound healing, cell shape and cell contraction. | GATOR complex protein Iml1; An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or [...] | 0.499 |
| RhoGEF2 | mbc | FBpp0086124 | FBpp0293271 | Rho guanine nucleotide exchange factor 2 (RhoGEF2) encodes a protein involved in actin organization and contractility. It contributes to multiple actin-based processes including wound healing, cell shape and cell contraction. | Myoblast city (mbc) encodes an unconventional bipartite GEF that, in combination with the product of Ced-12, activates the monomeric GTPase encoded by Rac1. It contributes to myoblast fusion, border cell migration and dorsal closure; Belongs to the DOCK family. | 0.915 |
| RhoGEF2 | tok | FBpp0086124 | FBpp0084069 | Rho guanine nucleotide exchange factor 2 (RhoGEF2) encodes a protein involved in actin organization and contractility. It contributes to multiple actin-based processes including wound healing, cell shape and cell contraction. | Metalloendopeptidase; Tolkin (tok) encodes a Zinc metallopeptidase with similar substrate specificity to the product of tld, which is its paralog. It cleaves the product of sog as well as the prodomains of several TGF-beta ligands. | 0.566 |
| cv-2 | Actbeta | FBpp0071536 | FBpp0088273 | Crossveinless 2 (cv-2) encodes a secreted protein that binds BMPs, the BMP receptor encoded by tkv and Heparan Sulfate Proteoglycans. It either promotes BMP signaling, as in the developing crossveins, or inhibits BMP signaling, as in the early embryo. | Inhibin beta chain; Controls several aspects of neuronal morphogenesis; essential for optic lobe development, EcR-B1 expression in larval brains, mushroom body remodeling, dorsal neuron morphogenesis and motoneuron axon guidance. Ligands Actbeta and daw act redundantly through the Activin receptor Babo and its transcriptional mediator Smad2 (Smox), to regulate neuroblast numbers and proliferation rates in the developing larval brain; Belongs to the TGF-beta family. | 0.422 |
| cv-2 | sog | FBpp0071536 | FBpp0309304 | Crossveinless 2 (cv-2) encodes a secreted protein that binds BMPs, the BMP receptor encoded by tkv and Heparan Sulfate Proteoglycans. It either promotes BMP signaling, as in the developing crossveins, or inhibits BMP signaling, as in the early embryo. | Dorsal-ventral patterning protein Sog; Short gastrulation (sog) encodes a secreted BMP antagonist that is expressed in the embryonic ventral neuroectoderm. sog product promotes neural development by preventing dorsally produced dpp from diffusing into the neuroectoderm and suppressing expression of neural genes. sog protein also diffuses dorsally where it helps establish a BMP activity gradient essential for partitioning that domain into cells giving rise to the dorsal epidermis versus amnioserosa. | 0.957 |
| cv-2 | tld | FBpp0071536 | FBpp0084070 | Crossveinless 2 (cv-2) encodes a secreted protein that binds BMPs, the BMP receptor encoded by tkv and Heparan Sulfate Proteoglycans. It either promotes BMP signaling, as in the developing crossveins, or inhibits BMP signaling, as in the early embryo. | Dorsal-ventral patterning protein tolloid; Tolloid (tld) encodes a member of the asticin metalloprotease family. Its primary function is to cleave the product of sog, which facilitates the diffusion of the ligand encoded by dpp to the dorsal-most cells in the early blastoderm embryo, helping to specify formation of the amnioserosa. | 0.850 |
| cv-2 | tok | FBpp0071536 | FBpp0084069 | Crossveinless 2 (cv-2) encodes a secreted protein that binds BMPs, the BMP receptor encoded by tkv and Heparan Sulfate Proteoglycans. It either promotes BMP signaling, as in the developing crossveins, or inhibits BMP signaling, as in the early embryo. | Metalloendopeptidase; Tolkin (tok) encodes a Zinc metallopeptidase with similar substrate specificity to the product of tld, which is its paralog. It cleaves the product of sog as well as the prodomains of several TGF-beta ligands. | 0.526 |
| mbc | Iml1 | FBpp0293271 | FBpp0072587 | Myoblast city (mbc) encodes an unconventional bipartite GEF that, in combination with the product of Ced-12, activates the monomeric GTPase encoded by Rac1. It contributes to myoblast fusion, border cell migration and dorsal closure; Belongs to the DOCK family. | GATOR complex protein Iml1; An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or [...] | 0.504 |
| mbc | RhoGEF2 | FBpp0293271 | FBpp0086124 | Myoblast city (mbc) encodes an unconventional bipartite GEF that, in combination with the product of Ced-12, activates the monomeric GTPase encoded by Rac1. It contributes to myoblast fusion, border cell migration and dorsal closure; Belongs to the DOCK family. | Rho guanine nucleotide exchange factor 2 (RhoGEF2) encodes a protein involved in actin organization and contractility. It contributes to multiple actin-based processes including wound healing, cell shape and cell contraction. | 0.915 |
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