STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AstAAllatostatin-A; May act as a neurotransmitter or neuromodulator. (151 aa)    
Predicted Functional Partners:
sNPF
Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep.
   
  
 0.913
Tk
Tachykinin-associated peptide 1; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Stimulates gut muscle contractions. Required for the response to the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males. The Gr68a gustatory receptor is required for detection of the pheromone and Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) which le [...]
   
  
 0.846
NPF
Neuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...]
   
  
 0.844
AstC
Allatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease.
   
  
 0.841
Lk
Leucokinin (Lk) encodes a neuropeptide that regulates water balance and food intake. Three groups of leucokinergic neurons are identified in the brain and abdominal ganglion of larvae and adults. Serotonin and insulin peptides have receptors in the abdominal leucokinergic neurons.
   
  
 0.840
CCAP
Crustacean cardioactive peptide (CCAP) encodes a conserved 9 amino acid neuropeptide. It is produced by 1-2 neurons in each segment of the ventral nervous system and is released during the shedding of the old exoskeleton (ecdysis). It also has cardioactive functions.
   
  
 0.840
Akh
Adipokinetic hormone (Akh) encodes a peptide hormone secreted by the corpora cardiaca. It signals to the G-protein coupled receptor encoded by AkhR to regulate circulating hemolymph carbohydrates and stored lipid and glycogen in the fat body; Belongs to the AKH/HRTH/RPCH family.
      
 0.836
AstA-R2
Allatostatin A receptor 2 (AstA-R2) encodes a receptor of the neuropeptide encoded by AstA. The interaction of both proteins modulates insulin and AKH signaling from cells of the corpus cardiaca; Belongs to the G-protein coupled receptor 1 family.
    
 
 0.835
Dh44
Diuretic hormone 44, isoform A; Hormone activity; G protein-coupled receptor binding; diuretic hormone activity; neuropeptide hormone activity. It is involved in the biological process described with: locomotor rhythm; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; body fluid secretion; hormone-mediated signaling pathway.
   
  
 0.794
AstA-R1
Allatostatin A receptor 1 (AstA-R1) encodes a G-protein coupled receptor for the neuropeptide encoded by AstA.
      
 0.775
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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