STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
toProtein takeout; Participates in a novel circadian output pathway that conveys temporal and food status information to feeding-relevant metabolisms and activities. Involved in male courtship behavior. In the brain- associated fat body, transcription is enhanced by the dsx and fru male- specific isoforms and repressed by the dsx female-specific isoform. (249 aa)    
Predicted Functional Partners:
CG16820
GH15921p.
      
 0.497
Top3beta
DNA topoisomerase 3-beta; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. [...]
      
 0.495
RpS24
Ribosomal protein S24 (RpS24) encodes an essential component of the small ribosomal subunit that functions in protein synthesis. It is classified as a 'Minute' gene as heterozygous mutants exhibit a slower developmental rate and small adult bristles; Belongs to the eukaryotic ribosomal protein eS24 family.
   
 
 0.461
RpS15
Ribosomal protein S15 (RpS15) encodes a protein that plays a role in assembly, structure and function of the ribosome and functions in protein synthesis. It is phosphorylated by the kinase encoded by Lrrk, causing protein synthesis upregulation; Belongs to the universal ribosomal protein uS19 family.
   
   0.451
Pcp
Pupal cuticle protein; Component of the cuticle of the pupa of fruit fly.
    
 
 0.443
metl
Methyltransferase-like protein; Probable methyltransferase.
      
 0.430
RpS11
40S ribosomal protein S11; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the universal ribosomal protein uS17 family.
   
 
 0.428
Top2
DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. During meiosis, it disrupts heterochromatic connections between achiasmate and chiasmate homologs after spindle assembly so that chromosomes can separate at prometaphase I. During mitosis, it functions in the separation of sister chromatids by establishing amphitelic kinetochore attachments in mitotic spindles. May have a role in chromatin [...]
      
 0.422
Top1
DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex (By similarity). Introduces a single-strand break via transesterification at a target site in duplex DNA (By similarity). The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand (By similarity). The free DNA strand then undergoes passage around the unb [...]
      
 0.420
RpS29
40S ribosomal protein S29; Zinc ion binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation.
   
   0.415
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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