Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ccz1 | Rab7 | FBpp0073036 | FBpp0083891 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. | 0.972 |
| Ccz1 | Syx7 | FBpp0073036 | FBpp0078008 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | Syntaxin 7 (Syx7) encodes a SNARE protein that is part of the core machinery (including the products of Rab5, Rbsn-5, and Vps45) by which endocytic cargo vesicles fuse with the early endosome. | 0.648 |
| Ccz1 | Vps11 | FBpp0073036 | FBpp0070045 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | Vacuolar protein sorting 11 (Vps11) encodes a Class C Vps core subunit of HOPS, a heterohexameric tethering complex that consists of the products of car, dor, lt, Vps11, Vps16A and Vps39. HOPS tethers autophagosomes or late endosomes with lysosomes to facilitate fusion. The product of Vps11 roles include autophagosome-lysosome fusion, late endosome-lysosome fusion and biosynthetic trafficking to lysosomes. | 0.991 |
| Ccz1 | Vps16A | FBpp0073036 | FBpp0081459 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | Vacuolar protein sorting 16A (Vps16A) encodes a subunit of a heterohexameric tethering complex known as homotypic fusion and protein sorting (HOPS). HOPS roles include promoting the fusion of late endosomes, autophagosomes, biosynthetic vesicles, and lysosomes, and the biogenesis of lysosome-related eye pigment granules. The product of Vps16A is also part of miniCORVET (class C core vacuole/endosome tethering), a tethering complex involved in endosome maturation in nephrocytes and blood cells. | 0.988 |
| Ccz1 | Vps33B | FBpp0073036 | FBpp0084210 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | Vacuolar protein sorting 33B (Vps33B) encodes a member of the family of SM proteins, which in conjunction with SNARE proteins catalyze membrane fusion events. The product of Vps33B, together with its binding partner encoded by Vps16B, forms a complex that is necessary for fusions between phagosomes and lysosomes; Belongs to the STXBP/unc-18/SEC1 family. | 0.937 |
| Ccz1 | Vps39 | FBpp0073036 | FBpp0083022 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | Vacuolar protein sorting 39 (Vps39) encodes a subunit of the homotypic fusion and vacuole protein sorting (HOPS) complex required for autophagosome maturation. | 0.991 |
| Ccz1 | Vps8 | FBpp0073036 | FBpp0076695 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | Vacuolar protein sorting-associated protein 8 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. Specifically required for endocytic trafficking in a subset of cells, such as hemocytes and nephrocytes, which are highly active in endocytosis. | 0.825 |
| Ccz1 | dor | FBpp0073036 | FBpp0070259 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. In larval neuromuscular junctions, essential for endosomal sorting which traffics old or dysfunctional synaptic vesicle proteins through a degradative endolysosomal route. Required for the biogenesis of eye pigment granules. Required to maintain normal levels of rush, which functions in endosome formation [...] | 0.976 |
| Ccz1 | lt | FBpp0073036 | FBpp0310509 | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | Vacuolar protein sorting-associated protein 41 homolog; Light (lt) encodes a cellular-protein trafficking protein that forms part of the homotypic fusion and vacuolar protein sorting (HOPS) and class C core vacuole/endosome tethering (CORVET) complexes. It is required for fusion of autophagosomes with lysosomes, endocytic down-regulation of Notch signaling, and eye pigment biogenesis; Belongs to the VPS41 family. | 0.980 |
| Rab7 | Ccz1 | FBpp0083891 | FBpp0073036 | Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | 0.972 |
| Rab7 | Syx7 | FBpp0083891 | FBpp0078008 | Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. | Syntaxin 7 (Syx7) encodes a SNARE protein that is part of the core machinery (including the products of Rab5, Rbsn-5, and Vps45) by which endocytic cargo vesicles fuse with the early endosome. | 0.843 |
| Rab7 | Vps11 | FBpp0083891 | FBpp0070045 | Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. | Vacuolar protein sorting 11 (Vps11) encodes a Class C Vps core subunit of HOPS, a heterohexameric tethering complex that consists of the products of car, dor, lt, Vps11, Vps16A and Vps39. HOPS tethers autophagosomes or late endosomes with lysosomes to facilitate fusion. The product of Vps11 roles include autophagosome-lysosome fusion, late endosome-lysosome fusion and biosynthetic trafficking to lysosomes. | 0.986 |
| Rab7 | Vps16A | FBpp0083891 | FBpp0081459 | Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. | Vacuolar protein sorting 16A (Vps16A) encodes a subunit of a heterohexameric tethering complex known as homotypic fusion and protein sorting (HOPS). HOPS roles include promoting the fusion of late endosomes, autophagosomes, biosynthetic vesicles, and lysosomes, and the biogenesis of lysosome-related eye pigment granules. The product of Vps16A is also part of miniCORVET (class C core vacuole/endosome tethering), a tethering complex involved in endosome maturation in nephrocytes and blood cells. | 0.991 |
| Rab7 | Vps33B | FBpp0083891 | FBpp0084210 | Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. | Vacuolar protein sorting 33B (Vps33B) encodes a member of the family of SM proteins, which in conjunction with SNARE proteins catalyze membrane fusion events. The product of Vps33B, together with its binding partner encoded by Vps16B, forms a complex that is necessary for fusions between phagosomes and lysosomes; Belongs to the STXBP/unc-18/SEC1 family. | 0.953 |
| Rab7 | Vps39 | FBpp0083891 | FBpp0083022 | Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. | Vacuolar protein sorting 39 (Vps39) encodes a subunit of the homotypic fusion and vacuole protein sorting (HOPS) complex required for autophagosome maturation. | 0.994 |
| Rab7 | Vps8 | FBpp0083891 | FBpp0076695 | Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. | Vacuolar protein sorting-associated protein 8 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. Specifically required for endocytic trafficking in a subset of cells, such as hemocytes and nephrocytes, which are highly active in endocytosis. | 0.736 |
| Rab7 | dor | FBpp0083891 | FBpp0070259 | Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. | Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. In larval neuromuscular junctions, essential for endosomal sorting which traffics old or dysfunctional synaptic vesicle proteins through a degradative endolysosomal route. Required for the biogenesis of eye pigment granules. Required to maintain normal levels of rush, which functions in endosome formation [...] | 0.991 |
| Rab7 | lt | FBpp0083891 | FBpp0310509 | Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. | Vacuolar protein sorting-associated protein 41 homolog; Light (lt) encodes a cellular-protein trafficking protein that forms part of the homotypic fusion and vacuolar protein sorting (HOPS) and class C core vacuole/endosome tethering (CORVET) complexes. It is required for fusion of autophagosomes with lysosomes, endocytic down-regulation of Notch signaling, and eye pigment biogenesis; Belongs to the VPS41 family. | 0.993 |
| Syx7 | Ccz1 | FBpp0078008 | FBpp0073036 | Syntaxin 7 (Syx7) encodes a SNARE protein that is part of the core machinery (including the products of Rab5, Rbsn-5, and Vps45) by which endocytic cargo vesicles fuse with the early endosome. | Caffeine, calcium, zinc sensitivity 1 (Ccz1) encodes a protein that forms a complex with the product of Mon1 and acts as an exchange factor of the small G-protein encoded by Rab7. The Ccz1/Mon1 complex activates and recruits the product of Rab7 to the maturing endosome, where it organizes the fusion of the matured endosome with the lysosome. Ccz1/Mon1 complex loss of function results in Rab7 phenotypes. | 0.648 |
| Syx7 | Rab7 | FBpp0078008 | FBpp0083891 | Syntaxin 7 (Syx7) encodes a SNARE protein that is part of the core machinery (including the products of Rab5, Rbsn-5, and Vps45) by which endocytic cargo vesicles fuse with the early endosome. | Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. | 0.843 |
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