node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADD1 | CG4119 | FBpp0087148 | FBpp0309405 | ADD domain-containing protein 1 (ADD1) encodes a strong Heterochromatin Protein 1 interactor that interacts with methylated H3K9 silencing marks in heterochromatin. | BcDNA.LD23634; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome. | 0.641 |
ADD1 | Daxx | FBpp0087148 | FBpp0078890 | ADD domain-containing protein 1 (ADD1) encodes a strong Heterochromatin Protein 1 interactor that interacts with methylated H3K9 silencing marks in heterochromatin. | Daxx-like protein; Transcription regulator. Acts as a histone chaperone that facilitates deposition of histone H3.3. Has a role in chromatin remodeling together with asf1 and XNP. Has role in the transcriptional apoptotic response to oxidative and UV stress. | 0.948 |
ADD1 | Dref | FBpp0087148 | FBpp0079485 | ADD domain-containing protein 1 (ADD1) encodes a strong Heterochromatin Protein 1 interactor that interacts with methylated H3K9 silencing marks in heterochromatin. | DNA replication-related element factor (Dref) encodes a BED finger-type transcription factor that binds to the DRE sequence (TATCGATA). The Dref product is involved in tumor suppressor, TOR, JNK and EGFR signalling pathways. It also plays a role in chromatin organization including insulator function, chromatin remodeling, and telomere maintenance. | 0.402 |
ADD1 | Nipped-B | FBpp0087148 | FBpp0110411 | ADD domain-containing protein 1 (ADD1) encodes a strong Heterochromatin Protein 1 interactor that interacts with methylated H3K9 silencing marks in heterochromatin. | Nipped-B protein; Plays a structural role in chromatin. Involved in sister chromatid cohesion, probably via an interaction with the cohesin complex. Participates in the transcriptional activation mediated by remote enhancers on genes such as cut and Ubx, possibly by alleviating the cohesin-mediated blocking of enhancer-promoter communication. Belongs to the SCC2/Nipped-B family. | 0.650 |
ADD1 | SMC5 | FBpp0087148 | FBpp0290815 | ADD domain-containing protein 1 (ADD1) encodes a strong Heterochromatin Protein 1 interactor that interacts with methylated H3K9 silencing marks in heterochromatin. | Structural maintenance of chromosomes 5 (SMC5) encodes a component of the SMC5/6 protein complex that is critical to genome stability and required for homologous DNA recombination-based processes. | 0.621 |
ADD1 | Su(var)205 | FBpp0087148 | FBpp0079252 | ADD domain-containing protein 1 (ADD1) encodes a strong Heterochromatin Protein 1 interactor that interacts with methylated H3K9 silencing marks in heterochromatin. | Heterochromatin protein 1; Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. | 0.850 |
ADD1 | XNP | FBpp0087148 | FBpp0084213 | ADD domain-containing protein 1 (ADD1) encodes a strong Heterochromatin Protein 1 interactor that interacts with methylated H3K9 silencing marks in heterochromatin. | Transcriptional regulator ATRX homolog; XNP (XNP) encodes two protein isoforms that participate in the maintenance of heterochromatin and chromosomal stability. They interact with heterochromatin proteins such as those encoded by Su(var)205 and ADD1; Belongs to the SNF2/RAD54 helicase family. | 0.852 |
ADD1 | spn-A | FBpp0087148 | FBpp0084955 | ADD domain-containing protein 1 (ADD1) encodes a strong Heterochromatin Protein 1 interactor that interacts with methylated H3K9 silencing marks in heterochromatin. | DNA repair protein Rad51 homolog; Spindle A (spn-A) encodes a protein that forms a filament on single-stranded DNA, does a homology search of double-stranded DNA, and catalyzes strand exchange, swapping the single-strand DNA in and displacing the partner of the complementary strand. | 0.810 |
ADD1 | tho2 | FBpp0087148 | FBpp0290874 | ADD domain-containing protein 1 (ADD1) encodes a strong Heterochromatin Protein 1 interactor that interacts with methylated H3K9 silencing marks in heterochromatin. | Tho2, isoform B; Tho2 (tho2) encodes a component of the THO complex that plays an essential role in nuclear export of mRNAs. | 0.761 |
CG12672 | XNP | FBpp0074313 | FBpp0084213 | Uncharacterized protein. | Transcriptional regulator ATRX homolog; XNP (XNP) encodes two protein isoforms that participate in the maintenance of heterochromatin and chromosomal stability. They interact with heterochromatin proteins such as those encoded by Su(var)205 and ADD1; Belongs to the SNF2/RAD54 helicase family. | 0.677 |
CG4119 | ADD1 | FBpp0309405 | FBpp0087148 | BcDNA.LD23634; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome. | ADD domain-containing protein 1 (ADD1) encodes a strong Heterochromatin Protein 1 interactor that interacts with methylated H3K9 silencing marks in heterochromatin. | 0.641 |
CG4119 | XNP | FBpp0309405 | FBpp0084213 | BcDNA.LD23634; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome. | Transcriptional regulator ATRX homolog; XNP (XNP) encodes two protein isoforms that participate in the maintenance of heterochromatin and chromosomal stability. They interact with heterochromatin proteins such as those encoded by Su(var)205 and ADD1; Belongs to the SNF2/RAD54 helicase family. | 0.650 |
CG4119 | tho2 | FBpp0309405 | FBpp0290874 | BcDNA.LD23634; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome. | Tho2, isoform B; Tho2 (tho2) encodes a component of the THO complex that plays an essential role in nuclear export of mRNAs. | 0.405 |
Daxx | ADD1 | FBpp0078890 | FBpp0087148 | Daxx-like protein; Transcription regulator. Acts as a histone chaperone that facilitates deposition of histone H3.3. Has a role in chromatin remodeling together with asf1 and XNP. Has role in the transcriptional apoptotic response to oxidative and UV stress. | ADD domain-containing protein 1 (ADD1) encodes a strong Heterochromatin Protein 1 interactor that interacts with methylated H3K9 silencing marks in heterochromatin. | 0.948 |
Daxx | Su(var)205 | FBpp0078890 | FBpp0079252 | Daxx-like protein; Transcription regulator. Acts as a histone chaperone that facilitates deposition of histone H3.3. Has a role in chromatin remodeling together with asf1 and XNP. Has role in the transcriptional apoptotic response to oxidative and UV stress. | Heterochromatin protein 1; Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. | 0.484 |
Daxx | XNP | FBpp0078890 | FBpp0084213 | Daxx-like protein; Transcription regulator. Acts as a histone chaperone that facilitates deposition of histone H3.3. Has a role in chromatin remodeling together with asf1 and XNP. Has role in the transcriptional apoptotic response to oxidative and UV stress. | Transcriptional regulator ATRX homolog; XNP (XNP) encodes two protein isoforms that participate in the maintenance of heterochromatin and chromosomal stability. They interact with heterochromatin proteins such as those encoded by Su(var)205 and ADD1; Belongs to the SNF2/RAD54 helicase family. | 0.953 |
Dref | ADD1 | FBpp0079485 | FBpp0087148 | DNA replication-related element factor (Dref) encodes a BED finger-type transcription factor that binds to the DRE sequence (TATCGATA). The Dref product is involved in tumor suppressor, TOR, JNK and EGFR signalling pathways. It also plays a role in chromatin organization including insulator function, chromatin remodeling, and telomere maintenance. | ADD domain-containing protein 1 (ADD1) encodes a strong Heterochromatin Protein 1 interactor that interacts with methylated H3K9 silencing marks in heterochromatin. | 0.402 |
Dref | XNP | FBpp0079485 | FBpp0084213 | DNA replication-related element factor (Dref) encodes a BED finger-type transcription factor that binds to the DRE sequence (TATCGATA). The Dref product is involved in tumor suppressor, TOR, JNK and EGFR signalling pathways. It also plays a role in chromatin organization including insulator function, chromatin remodeling, and telomere maintenance. | Transcriptional regulator ATRX homolog; XNP (XNP) encodes two protein isoforms that participate in the maintenance of heterochromatin and chromosomal stability. They interact with heterochromatin proteins such as those encoded by Su(var)205 and ADD1; Belongs to the SNF2/RAD54 helicase family. | 0.734 |
Nipped-B | ADD1 | FBpp0110411 | FBpp0087148 | Nipped-B protein; Plays a structural role in chromatin. Involved in sister chromatid cohesion, probably via an interaction with the cohesin complex. Participates in the transcriptional activation mediated by remote enhancers on genes such as cut and Ubx, possibly by alleviating the cohesin-mediated blocking of enhancer-promoter communication. Belongs to the SCC2/Nipped-B family. | ADD domain-containing protein 1 (ADD1) encodes a strong Heterochromatin Protein 1 interactor that interacts with methylated H3K9 silencing marks in heterochromatin. | 0.650 |
Nipped-B | SMC5 | FBpp0110411 | FBpp0290815 | Nipped-B protein; Plays a structural role in chromatin. Involved in sister chromatid cohesion, probably via an interaction with the cohesin complex. Participates in the transcriptional activation mediated by remote enhancers on genes such as cut and Ubx, possibly by alleviating the cohesin-mediated blocking of enhancer-promoter communication. Belongs to the SCC2/Nipped-B family. | Structural maintenance of chromosomes 5 (SMC5) encodes a component of the SMC5/6 protein complex that is critical to genome stability and required for homologous DNA recombination-based processes. | 0.949 |