node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cpn | Lrrk | FBpp0082021 | FBpp0306703 | Calphotin (Cpn) encodes a glutamic acid-rich protein with a strong negative charge and a highly hydrophobic amino acid composition. It functions as an immobile Ca[2+] buffer along the base of the photoreceptor's microvilli. It protects the photoreceptor cells from Ca[2+] overload and light induced degeneration. | Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. | 0.498 |
Cpn | Rh3 | FBpp0082021 | FBpp0083284 | Calphotin (Cpn) encodes a glutamic acid-rich protein with a strong negative charge and a highly hydrophobic amino acid composition. It functions as an immobile Ca[2+] buffer along the base of the photoreceptor's microvilli. It protects the photoreceptor cells from Ca[2+] overload and light induced degeneration. | Rhodopsin 3 (Rh3) encodes a Rhodopsin GPCR protein that responds to UV light and activates the phototransduction cascade that leads to photoreceptor depolarization. Rh3 is expressed in R7 photoreceptors in a stochastic manner: 35% of R7 photoreceptors express Rh3 while the remaining 65% express another UV-sensitive Rhodopsin encoded by Rh4. | 0.858 |
Cpn | boss | FBpp0082021 | FBpp0084323 | Calphotin (Cpn) encodes a glutamic acid-rich protein with a strong negative charge and a highly hydrophobic amino acid composition. It functions as an immobile Ca[2+] buffer along the base of the photoreceptor's microvilli. It protects the photoreceptor cells from Ca[2+] overload and light induced degeneration. | Protein bride of sevenless; Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. | 0.669 |
Dlc90F | Lrrk | FBpp0082996 | FBpp0306703 | Dynein light chain Tctex-type; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Required for spermatid differentiation. Is not required for polarized transport in rhabdomere development and appears to be a non-essential component of the cytoplasmic dynein complex. | Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. | 0.641 |
Dlc90F | boss | FBpp0082996 | FBpp0084323 | Dynein light chain Tctex-type; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Required for spermatid differentiation. Is not required for polarized transport in rhabdomere development and appears to be a non-essential component of the cytoplasmic dynein complex. | Protein bride of sevenless; Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. | 0.531 |
Dlc90F | pico | FBpp0082996 | FBpp0074573 | Dynein light chain Tctex-type; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Required for spermatid differentiation. Is not required for polarized transport in rhabdomere development and appears to be a non-essential component of the cytoplasmic dynein complex. | Pico, isoform A; Pico (pico) encodes an intracellular adapter protein belonging to the MRL family of proteins, which transduce signals from growth factor receptors to changes in the actin cytoskeleton. Its roles include the regulation of growth and cell migration. | 0.569 |
Eh | boss | FBpp0082885 | FBpp0084323 | Eclosion hormone (Eh) encodes a neurohormone involved in the control of ecdysis. At each ecdysis, the neurohormone is released into the hemolymph where it serves to potentiate the release of the product of ETH through a positive endocrine feedback loop. The product of Eh is also released into the nervous system where it contributes to turning on ecdysis. | Protein bride of sevenless; Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. | 0.617 |
Lrrk | Cpn | FBpp0306703 | FBpp0082021 | Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. | Calphotin (Cpn) encodes a glutamic acid-rich protein with a strong negative charge and a highly hydrophobic amino acid composition. It functions as an immobile Ca[2+] buffer along the base of the photoreceptor's microvilli. It protects the photoreceptor cells from Ca[2+] overload and light induced degeneration. | 0.498 |
Lrrk | Dlc90F | FBpp0306703 | FBpp0082996 | Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. | Dynein light chain Tctex-type; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Required for spermatid differentiation. Is not required for polarized transport in rhabdomere development and appears to be a non-essential component of the cytoplasmic dynein complex. | 0.641 |
Lrrk | boss | FBpp0306703 | FBpp0084323 | Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. | Protein bride of sevenless; Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. | 0.534 |
Rh3 | Cpn | FBpp0083284 | FBpp0082021 | Rhodopsin 3 (Rh3) encodes a Rhodopsin GPCR protein that responds to UV light and activates the phototransduction cascade that leads to photoreceptor depolarization. Rh3 is expressed in R7 photoreceptors in a stochastic manner: 35% of R7 photoreceptors express Rh3 while the remaining 65% express another UV-sensitive Rhodopsin encoded by Rh4. | Calphotin (Cpn) encodes a glutamic acid-rich protein with a strong negative charge and a highly hydrophobic amino acid composition. It functions as an immobile Ca[2+] buffer along the base of the photoreceptor's microvilli. It protects the photoreceptor cells from Ca[2+] overload and light induced degeneration. | 0.858 |
Rh3 | boss | FBpp0083284 | FBpp0084323 | Rhodopsin 3 (Rh3) encodes a Rhodopsin GPCR protein that responds to UV light and activates the phototransduction cascade that leads to photoreceptor depolarization. Rh3 is expressed in R7 photoreceptors in a stochastic manner: 35% of R7 photoreceptors express Rh3 while the remaining 65% express another UV-sensitive Rhodopsin encoded by Rh4. | Protein bride of sevenless; Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. | 0.611 |
Rh3 | sev | FBpp0083284 | FBpp0073249 | Rhodopsin 3 (Rh3) encodes a Rhodopsin GPCR protein that responds to UV light and activates the phototransduction cascade that leads to photoreceptor depolarization. Rh3 is expressed in R7 photoreceptors in a stochastic manner: 35% of R7 photoreceptors express Rh3 while the remaining 65% express another UV-sensitive Rhodopsin encoded by Rh4. | Protein sevenless; Receptor for an extracellular signal required to instruct a cell to differentiate into an R7 photoreceptor. The ligand for sev is the boss (bride of sevenless) protein on the surface of the neighboring R8 cell. | 0.665 |
SP555 | boss | FBpp0078643 | FBpp0084323 | SP555, isoform A; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process. | Protein bride of sevenless; Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. | 0.509 |
boss | Cpn | FBpp0084323 | FBpp0082021 | Protein bride of sevenless; Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. | Calphotin (Cpn) encodes a glutamic acid-rich protein with a strong negative charge and a highly hydrophobic amino acid composition. It functions as an immobile Ca[2+] buffer along the base of the photoreceptor's microvilli. It protects the photoreceptor cells from Ca[2+] overload and light induced degeneration. | 0.669 |
boss | Dlc90F | FBpp0084323 | FBpp0082996 | Protein bride of sevenless; Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. | Dynein light chain Tctex-type; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Required for spermatid differentiation. Is not required for polarized transport in rhabdomere development and appears to be a non-essential component of the cytoplasmic dynein complex. | 0.531 |
boss | Eh | FBpp0084323 | FBpp0082885 | Protein bride of sevenless; Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. | Eclosion hormone (Eh) encodes a neurohormone involved in the control of ecdysis. At each ecdysis, the neurohormone is released into the hemolymph where it serves to potentiate the release of the product of ETH through a positive endocrine feedback loop. The product of Eh is also released into the nervous system where it contributes to turning on ecdysis. | 0.617 |
boss | Lrrk | FBpp0084323 | FBpp0306703 | Protein bride of sevenless; Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. | Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. | 0.534 |
boss | Rh3 | FBpp0084323 | FBpp0083284 | Protein bride of sevenless; Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. | Rhodopsin 3 (Rh3) encodes a Rhodopsin GPCR protein that responds to UV light and activates the phototransduction cascade that leads to photoreceptor depolarization. Rh3 is expressed in R7 photoreceptors in a stochastic manner: 35% of R7 photoreceptors express Rh3 while the remaining 65% express another UV-sensitive Rhodopsin encoded by Rh4. | 0.611 |
boss | SP555 | FBpp0084323 | FBpp0078643 | Protein bride of sevenless; Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. | SP555, isoform A; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process. | 0.509 |