node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ankle2 | CG8878 | FBpp0290628 | FBpp0089096 | Ankyrin repeat and LEM domain containing 2, isoform D; Ankle2 (Ankle2) encodes an important protein for proper development of the third instar larval CNS. Ankle2 loss causes a small brain phenotype, defects in proliferation and excessive apoptosis. | BcDNA.LD23371; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: regulation of gene expression, epigenetic; Wnt signaling pathway; peptidyl-serine phosphorylation. | 0.860 |
Ankle2 | baf | FBpp0290628 | FBpp0305308 | Ankyrin repeat and LEM domain containing 2, isoform D; Ankle2 (Ankle2) encodes an important protein for proper development of the third instar larval CNS. Ankle2 loss causes a small brain phenotype, defects in proliferation and excessive apoptosis. | Barrier-to-autointegration factor; Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Functions are required in both M phase and interphase of the cell cycle. Belongs to the BAF family. | 0.859 |
Ankle2 | ball | FBpp0290628 | FBpp0084465 | Ankyrin repeat and LEM domain containing 2, isoform D; Ankle2 (Ankle2) encodes an important protein for proper development of the third instar larval CNS. Ankle2 loss causes a small brain phenotype, defects in proliferation and excessive apoptosis. | Nucleosomal histone kinase 1; Serine/threonine-protein kinase involved in somatic mitosis and female meiosis. Required for spindle organization in mitosis, and for the establishment or maintenance of meiosis- specific chromosomal configurations, including the prophase I karyosome and the metaphase I spindle. Specifically phosphorylates nucleosomal H2A on 'Thr-119'. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere. Belongs to the protei [...] | 0.945 |
Ankle2 | l(2)gl | FBpp0290628 | FBpp0297547 | Ankyrin repeat and LEM domain containing 2, isoform D; Ankle2 (Ankle2) encodes an important protein for proper development of the third instar larval CNS. Ankle2 loss causes a small brain phenotype, defects in proliferation and excessive apoptosis. | Lethal(2) giant larvae protein; Essential for the development of polarized epithelia, for cell polarity associated with asymmetric cell division of neuroblasts during development, and for oocyte polarity formation. Promotes the formation of actin-rich projections at the oocyte cortex and the posterior enrichment of par-1 which is required for oocyte polarization. Regulates the localization of axis-specifying morphogens such as stau and grk. [Isoform p127]: Has an accessory function in control of cell proliferation and differentiation during development. | 0.663 |
CG7378 | CG8878 | FBpp0309670 | FBpp0089096 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | BcDNA.LD23371; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: regulation of gene expression, epigenetic; Wnt signaling pathway; peptidyl-serine phosphorylation. | 0.709 |
CG7378 | ball | FBpp0309670 | FBpp0084465 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Nucleosomal histone kinase 1; Serine/threonine-protein kinase involved in somatic mitosis and female meiosis. Required for spindle organization in mitosis, and for the establishment or maintenance of meiosis- specific chromosomal configurations, including the prophase I karyosome and the metaphase I spindle. Specifically phosphorylates nucleosomal H2A on 'Thr-119'. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere. Belongs to the protei [...] | 0.709 |
CG8878 | Ankle2 | FBpp0089096 | FBpp0290628 | BcDNA.LD23371; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: regulation of gene expression, epigenetic; Wnt signaling pathway; peptidyl-serine phosphorylation. | Ankyrin repeat and LEM domain containing 2, isoform D; Ankle2 (Ankle2) encodes an important protein for proper development of the third instar larval CNS. Ankle2 loss causes a small brain phenotype, defects in proliferation and excessive apoptosis. | 0.860 |
CG8878 | CG7378 | FBpp0089096 | FBpp0309670 | BcDNA.LD23371; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: regulation of gene expression, epigenetic; Wnt signaling pathway; peptidyl-serine phosphorylation. | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.709 |
CG8878 | baf | FBpp0089096 | FBpp0305308 | BcDNA.LD23371; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: regulation of gene expression, epigenetic; Wnt signaling pathway; peptidyl-serine phosphorylation. | Barrier-to-autointegration factor; Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Functions are required in both M phase and interphase of the cell cycle. Belongs to the BAF family. | 0.798 |
CG8878 | ball | FBpp0089096 | FBpp0084465 | BcDNA.LD23371; ATP binding; protein serine/threonine kinase activity. It is involved in the biological process described with: regulation of gene expression, epigenetic; Wnt signaling pathway; peptidyl-serine phosphorylation. | Nucleosomal histone kinase 1; Serine/threonine-protein kinase involved in somatic mitosis and female meiosis. Required for spindle organization in mitosis, and for the establishment or maintenance of meiosis- specific chromosomal configurations, including the prophase I karyosome and the metaphase I spindle. Specifically phosphorylates nucleosomal H2A on 'Thr-119'. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere. Belongs to the protei [...] | 0.864 |
Klp61F | aurB | FBpp0072616 | FBpp0079769 | Kinesin-like protein Klp61F; Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. Forms cross-links between microtubules within interpolar microtubule bundles. Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinet [...] | Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis. | 0.958 |
Klp61F | ball | FBpp0072616 | FBpp0084465 | Kinesin-like protein Klp61F; Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. Forms cross-links between microtubules within interpolar microtubule bundles. Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinet [...] | Nucleosomal histone kinase 1; Serine/threonine-protein kinase involved in somatic mitosis and female meiosis. Required for spindle organization in mitosis, and for the establishment or maintenance of meiosis- specific chromosomal configurations, including the prophase I karyosome and the metaphase I spindle. Specifically phosphorylates nucleosomal H2A on 'Thr-119'. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere. Belongs to the protei [...] | 0.692 |
Klp61F | ncd | FBpp0072616 | FBpp0311231 | Kinesin-like protein Klp61F; Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. Forms cross-links between microtubules within interpolar microtubule bundles. Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinet [...] | Protein claret segregational; Non-claret disjunctional (ncd) encodes a minus-end-directed kinesin microtubule motor protein and the sole member of the kinesin-14 motor family. It is required for spindle assembly in oocytes and chromosome attachment to spindles in early embryos; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily. | 0.992 |
Klp61F | tum | FBpp0072616 | FBpp0086767 | Kinesin-like protein Klp61F; Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. Forms cross-links between microtubules within interpolar microtubule bundles. Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinet [...] | Tumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation. | 0.952 |
Rho1 | aurB | FBpp0086354 | FBpp0079769 | Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...] | Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis. | 0.507 |
Rho1 | ball | FBpp0086354 | FBpp0084465 | Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...] | Nucleosomal histone kinase 1; Serine/threonine-protein kinase involved in somatic mitosis and female meiosis. Required for spindle organization in mitosis, and for the establishment or maintenance of meiosis- specific chromosomal configurations, including the prophase I karyosome and the metaphase I spindle. Specifically phosphorylates nucleosomal H2A on 'Thr-119'. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere. Belongs to the protei [...] | 0.711 |
Rho1 | tum | FBpp0086354 | FBpp0086767 | Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...] | Tumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation. | 0.879 |
aurB | Klp61F | FBpp0079769 | FBpp0072616 | Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis. | Kinesin-like protein Klp61F; Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. Forms cross-links between microtubules within interpolar microtubule bundles. Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinet [...] | 0.958 |
aurB | Rho1 | FBpp0079769 | FBpp0086354 | Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis. | Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...] | 0.507 |
aurB | baf | FBpp0079769 | FBpp0305308 | Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis. | Barrier-to-autointegration factor; Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Functions are required in both M phase and interphase of the cell cycle. Belongs to the BAF family. | 0.449 |