| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CG13229 | RYa-R | FBpp0303452 | FBpp0311444 | G protein-coupled receptor activity; G protein-coupled peptide receptor activity; neuropeptide receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway. | RYamide receptor; Receptor for the neuropeptides RYamide-1 and RYamide-2. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. RYamide signaling may suppress feeding behavior. | 0.600 |
| FMRFaR | MsR1 | FBpp0309525 | FBpp0303220 | FMRFamide Receptor (FMRFaR) encodes a G protein coupled receptor activated by all FMRFamide peptides. It contributes to neurotransmitter release, muscle contraction, and larval escape responses to light; Belongs to the G-protein coupled receptor 1 family. | Myosuppressin receptor 1 (MsR1) encodes a class A transmembrane G protein coupled receptor that binds the neuropeptide ligand encoded by Ms and acts through the adenylate cyclase-inhibiting GPCR signaling pathway. It inhibits visceral muscle contraction, and negatively regulates cardiac contractility and gut motility. | 0.423 |
| FMRFaR | MsR2 | FBpp0309525 | FBpp0303392 | FMRFamide Receptor (FMRFaR) encodes a G protein coupled receptor activated by all FMRFamide peptides. It contributes to neurotransmitter release, muscle contraction, and larval escape responses to light; Belongs to the G-protein coupled receptor 1 family. | Myosuppressin receptor 2 (MsR2) encodes a G protein coupled receptor activated by the product of Ms (TDVDHVFLRFamide). It elevates neurotransmitter release in motor neurons and aids larval escape responses to light. | 0.449 |
| FMRFaR | NPF | FBpp0309525 | FBpp0304075 | FMRFamide Receptor (FMRFaR) encodes a G protein coupled receptor activated by all FMRFamide peptides. It contributes to neurotransmitter release, muscle contraction, and larval escape responses to light; Belongs to the G-protein coupled receptor 1 family. | Neuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...] | 0.489 |
| FMRFaR | RYa-R | FBpp0309525 | FBpp0311444 | FMRFamide Receptor (FMRFaR) encodes a G protein coupled receptor activated by all FMRFamide peptides. It contributes to neurotransmitter release, muscle contraction, and larval escape responses to light; Belongs to the G-protein coupled receptor 1 family. | RYamide receptor; Receptor for the neuropeptides RYamide-1 and RYamide-2. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. RYamide signaling may suppress feeding behavior. | 0.679 |
| FMRFaR | Trissin | FBpp0309525 | FBpp0289411 | FMRFamide Receptor (FMRFaR) encodes a G protein coupled receptor activated by all FMRFamide peptides. It contributes to neurotransmitter release, muscle contraction, and larval escape responses to light; Belongs to the G-protein coupled receptor 1 family. | Trissin; Activates the G-protein coupled receptor TrissinR in vitro, leading to increased intracellular calcium ion levels. | 0.493 |
| FMRFaR | natalisin | FBpp0309525 | FBpp0290303 | FMRFamide Receptor (FMRFaR) encodes a G protein coupled receptor activated by all FMRFamide peptides. It contributes to neurotransmitter release, muscle contraction, and larval escape responses to light; Belongs to the G-protein coupled receptor 1 family. | Natalisin, isoform D; Natalisin (natalisin) encodes five signaling peptides with potent agonist activities toward the product of TkR86C. | 0.471 |
| FMRFaR | sNPF | FBpp0309525 | FBpp0080859 | FMRFamide Receptor (FMRFaR) encodes a G protein coupled receptor activated by all FMRFamide peptides. It contributes to neurotransmitter release, muscle contraction, and larval escape responses to light; Belongs to the G-protein coupled receptor 1 family. | Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. | 0.547 |
| MsR1 | FMRFaR | FBpp0303220 | FBpp0309525 | Myosuppressin receptor 1 (MsR1) encodes a class A transmembrane G protein coupled receptor that binds the neuropeptide ligand encoded by Ms and acts through the adenylate cyclase-inhibiting GPCR signaling pathway. It inhibits visceral muscle contraction, and negatively regulates cardiac contractility and gut motility. | FMRFamide Receptor (FMRFaR) encodes a G protein coupled receptor activated by all FMRFamide peptides. It contributes to neurotransmitter release, muscle contraction, and larval escape responses to light; Belongs to the G-protein coupled receptor 1 family. | 0.423 |
| MsR1 | NPF | FBpp0303220 | FBpp0304075 | Myosuppressin receptor 1 (MsR1) encodes a class A transmembrane G protein coupled receptor that binds the neuropeptide ligand encoded by Ms and acts through the adenylate cyclase-inhibiting GPCR signaling pathway. It inhibits visceral muscle contraction, and negatively regulates cardiac contractility and gut motility. | Neuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...] | 0.450 |
| MsR1 | RYa-R | FBpp0303220 | FBpp0311444 | Myosuppressin receptor 1 (MsR1) encodes a class A transmembrane G protein coupled receptor that binds the neuropeptide ligand encoded by Ms and acts through the adenylate cyclase-inhibiting GPCR signaling pathway. It inhibits visceral muscle contraction, and negatively regulates cardiac contractility and gut motility. | RYamide receptor; Receptor for the neuropeptides RYamide-1 and RYamide-2. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. RYamide signaling may suppress feeding behavior. | 0.760 |
| MsR1 | Trissin | FBpp0303220 | FBpp0289411 | Myosuppressin receptor 1 (MsR1) encodes a class A transmembrane G protein coupled receptor that binds the neuropeptide ligand encoded by Ms and acts through the adenylate cyclase-inhibiting GPCR signaling pathway. It inhibits visceral muscle contraction, and negatively regulates cardiac contractility and gut motility. | Trissin; Activates the G-protein coupled receptor TrissinR in vitro, leading to increased intracellular calcium ion levels. | 0.602 |
| MsR1 | sNPF | FBpp0303220 | FBpp0080859 | Myosuppressin receptor 1 (MsR1) encodes a class A transmembrane G protein coupled receptor that binds the neuropeptide ligand encoded by Ms and acts through the adenylate cyclase-inhibiting GPCR signaling pathway. It inhibits visceral muscle contraction, and negatively regulates cardiac contractility and gut motility. | Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. | 0.469 |
| MsR2 | FMRFaR | FBpp0303392 | FBpp0309525 | Myosuppressin receptor 2 (MsR2) encodes a G protein coupled receptor activated by the product of Ms (TDVDHVFLRFamide). It elevates neurotransmitter release in motor neurons and aids larval escape responses to light. | FMRFamide Receptor (FMRFaR) encodes a G protein coupled receptor activated by all FMRFamide peptides. It contributes to neurotransmitter release, muscle contraction, and larval escape responses to light; Belongs to the G-protein coupled receptor 1 family. | 0.449 |
| MsR2 | NPF | FBpp0303392 | FBpp0304075 | Myosuppressin receptor 2 (MsR2) encodes a G protein coupled receptor activated by the product of Ms (TDVDHVFLRFamide). It elevates neurotransmitter release in motor neurons and aids larval escape responses to light. | Neuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...] | 0.491 |
| MsR2 | RYa-R | FBpp0303392 | FBpp0311444 | Myosuppressin receptor 2 (MsR2) encodes a G protein coupled receptor activated by the product of Ms (TDVDHVFLRFamide). It elevates neurotransmitter release in motor neurons and aids larval escape responses to light. | RYamide receptor; Receptor for the neuropeptides RYamide-1 and RYamide-2. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. RYamide signaling may suppress feeding behavior. | 0.769 |
| MsR2 | Trissin | FBpp0303392 | FBpp0289411 | Myosuppressin receptor 2 (MsR2) encodes a G protein coupled receptor activated by the product of Ms (TDVDHVFLRFamide). It elevates neurotransmitter release in motor neurons and aids larval escape responses to light. | Trissin; Activates the G-protein coupled receptor TrissinR in vitro, leading to increased intracellular calcium ion levels. | 0.609 |
| MsR2 | natalisin | FBpp0303392 | FBpp0290303 | Myosuppressin receptor 2 (MsR2) encodes a G protein coupled receptor activated by the product of Ms (TDVDHVFLRFamide). It elevates neurotransmitter release in motor neurons and aids larval escape responses to light. | Natalisin, isoform D; Natalisin (natalisin) encodes five signaling peptides with potent agonist activities toward the product of TkR86C. | 0.424 |
| MsR2 | sNPF | FBpp0303392 | FBpp0080859 | Myosuppressin receptor 2 (MsR2) encodes a G protein coupled receptor activated by the product of Ms (TDVDHVFLRFamide). It elevates neurotransmitter release in motor neurons and aids larval escape responses to light. | Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. | 0.491 |
| NPF | FMRFaR | FBpp0304075 | FBpp0309525 | Neuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...] | FMRFamide Receptor (FMRFaR) encodes a G protein coupled receptor activated by all FMRFamide peptides. It contributes to neurotransmitter release, muscle contraction, and larval escape responses to light; Belongs to the G-protein coupled receptor 1 family. | 0.489 |