STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RYa-RRYamide receptor; Receptor for the neuropeptides RYamide-1 and RYamide-2. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. RYamide signaling may suppress feeding behavior. (518 aa)    
Predicted Functional Partners:
RYa
RYamide neuropeptides; Neuropeptides RYamide-1 and RYamide-2 are ligands for the G- protein coupled receptor RYa-R. May suppress feeding behavior.
    
 
 0.855
MsR2
Myosuppressin receptor 2 (MsR2) encodes a G protein coupled receptor activated by the product of Ms (TDVDHVFLRFamide). It elevates neurotransmitter release in motor neurons and aids larval escape responses to light.
  
  
 0.769
Proc-R
G protein-coupled receptor activity; proctolin receptor activity; neuropeptide receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; neuropeptide signaling pathway.
      
 0.764
MsR1
Myosuppressin receptor 1 (MsR1) encodes a class A transmembrane G protein coupled receptor that binds the neuropeptide ligand encoded by Ms and acts through the adenylate cyclase-inhibiting GPCR signaling pathway. It inhibits visceral muscle contraction, and negatively regulates cardiac contractility and gut motility.
  
   
 0.760
FMRFaR
FMRFamide Receptor (FMRFaR) encodes a G protein coupled receptor activated by all FMRFamide peptides. It contributes to neurotransmitter release, muscle contraction, and larval escape responses to light; Belongs to the G-protein coupled receptor 1 family.
      
 0.679
NPF
Neuropeptide F; Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to d [...]
      
 0.627
sNPF
Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep.
      
 0.625
CG13229
G protein-coupled receptor activity; G protein-coupled peptide receptor activity; neuropeptide receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway.
  
   
 0.600
Trissin
Trissin; Activates the G-protein coupled receptor TrissinR in vitro, leading to increased intracellular calcium ion levels.
      
 0.548
natalisin
Natalisin, isoform D; Natalisin (natalisin) encodes five signaling peptides with potent agonist activities toward the product of TkR86C.
   
  
 0.498
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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