node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG10041 | grass | FBpp0423040 | FBpp0084482 | FI16631p1; Serine-type endopeptidase activity. It is involved in the biological process described with: multicellular organism reproduction; proteolysis; Belongs to the peptidase S1 family. | Gram-positive Specific Serine protease (grass) encodes a secreted serine protease that is involved downstream of the microbial sensing receptors encoded by GNBP3 and PGRP-SA in the activation of the Toll pathway during the immune response. It functions downstream of the serine protease encoded by modSP and upstream of the enzyme encoded by SPE, which cleaves the product of spz; Belongs to the peptidase S1 family. CLIP subfamily. | 0.512 |
GNBP1 | GNBP3 | FBpp0074817 | FBpp0076237 | Gram-negative bacteria-binding protein 1; Plays a key role in innate immunity by acting as a pattern recognition receptor for beta-1,3-glucan from fungi and lipopolysaccharide from Gram-negative bacteria. Upon recognition of invading micro-organism-derived products, acts upstream of protease spz processing enzyme SPE to activate the Toll pathway and to induce the expression of antimicrobial peptides drosomycin, cecropin and attacin. Belongs to the insect beta-1,3-glucan binding protein family. | Gram-negative bacteria binding protein 3 (GNBP3) encodes a hemolymphatic protein involved in the sensing of glucan (a fungal cell wall component) upstream of the Toll pathway. | 0.581 |
GNBP1 | grass | FBpp0074817 | FBpp0084482 | Gram-negative bacteria-binding protein 1; Plays a key role in innate immunity by acting as a pattern recognition receptor for beta-1,3-glucan from fungi and lipopolysaccharide from Gram-negative bacteria. Upon recognition of invading micro-organism-derived products, acts upstream of protease spz processing enzyme SPE to activate the Toll pathway and to induce the expression of antimicrobial peptides drosomycin, cecropin and attacin. Belongs to the insect beta-1,3-glucan binding protein family. | Gram-positive Specific Serine protease (grass) encodes a secreted serine protease that is involved downstream of the microbial sensing receptors encoded by GNBP3 and PGRP-SA in the activation of the Toll pathway during the immune response. It functions downstream of the serine protease encoded by modSP and upstream of the enzyme encoded by SPE, which cleaves the product of spz; Belongs to the peptidase S1 family. CLIP subfamily. | 0.605 |
GNBP1 | modSP | FBpp0074817 | FBpp0082798 | Gram-negative bacteria-binding protein 1; Plays a key role in innate immunity by acting as a pattern recognition receptor for beta-1,3-glucan from fungi and lipopolysaccharide from Gram-negative bacteria. Upon recognition of invading micro-organism-derived products, acts upstream of protease spz processing enzyme SPE to activate the Toll pathway and to induce the expression of antimicrobial peptides drosomycin, cecropin and attacin. Belongs to the insect beta-1,3-glucan binding protein family. | Modular serine protease non-catalytic chain; Serine protease that plays a key role in innate immunity by activating the Toll pathway in response to infection with Gram-positive bacteria and fungi. During Gram- positive infection, acts downstream of PGRP-SA and upstream of Grass and Spz, and therefore appears to function in a pathway that links detection of Gram-positive lysine-type peptidoglycans to Toll activation. Functions in a separate pathway to the psh-mediated activation of the Toll pathway. Belongs to the peptidase S1 family. | 0.984 |
GNBP1 | psh | FBpp0074817 | FBpp0074400 | Gram-negative bacteria-binding protein 1; Plays a key role in innate immunity by acting as a pattern recognition receptor for beta-1,3-glucan from fungi and lipopolysaccharide from Gram-negative bacteria. Upon recognition of invading micro-organism-derived products, acts upstream of protease spz processing enzyme SPE to activate the Toll pathway and to induce the expression of antimicrobial peptides drosomycin, cecropin and attacin. Belongs to the insect beta-1,3-glucan binding protein family. | Serine protease persephone; Serine protease that plays a key role in innate immunity in response to Gram-positive bacterial and fungal proteases. Acts as a component of the Toll pathway upstream of protease spz processing enzyme SPE and Tl ligand spz. Nec regulates the cascade by inhibiting psh ; Belongs to the peptidase S1 family. CLIP subfamily. | 0.852 |
GNBP1 | sphe | FBpp0074817 | FBpp0074137 | Gram-negative bacteria-binding protein 1; Plays a key role in innate immunity by acting as a pattern recognition receptor for beta-1,3-glucan from fungi and lipopolysaccharide from Gram-negative bacteria. Upon recognition of invading micro-organism-derived products, acts upstream of protease spz processing enzyme SPE to activate the Toll pathway and to induce the expression of antimicrobial peptides drosomycin, cecropin and attacin. Belongs to the insect beta-1,3-glucan binding protein family. | Spheroide (sphe) encodes a serine protein homologue, a serine protease with no catalytic activity. | 0.690 |
GNBP1 | sphinx1 | FBpp0074817 | FBpp0289592 | Gram-negative bacteria-binding protein 1; Plays a key role in innate immunity by acting as a pattern recognition receptor for beta-1,3-glucan from fungi and lipopolysaccharide from Gram-negative bacteria. Upon recognition of invading micro-organism-derived products, acts upstream of protease spz processing enzyme SPE to activate the Toll pathway and to induce the expression of antimicrobial peptides drosomycin, cecropin and attacin. Belongs to the insect beta-1,3-glucan binding protein family. | Sphinx1 (sphinx1) encodes a protein related to the serine protease homolog, which is strongly expressed in the male accessory gland. | 0.688 |
GNBP1 | spz | FBpp0074817 | FBpp0084507 | Gram-negative bacteria-binding protein 1; Plays a key role in innate immunity by acting as a pattern recognition receptor for beta-1,3-glucan from fungi and lipopolysaccharide from Gram-negative bacteria. Upon recognition of invading micro-organism-derived products, acts upstream of protease spz processing enzyme SPE to activate the Toll pathway and to induce the expression of antimicrobial peptides drosomycin, cecropin and attacin. Belongs to the insect beta-1,3-glucan binding protein family. | Protein spaetzle C-106; Spatzle (spz) encodes a secreted protein which, after cleavage by an extracellular serine protease (encoded by ea or SPE), can induce the dimerization of the product of Tl, and the subsequent activation of the Toll pathway. It contributes to function of the Toll signaling cascade, which plays a key role in various developmental and immune processes, notably embryonic dorso-ventral patterning and regulation of antimicrobial peptides. | 0.805 |
GNBP3 | GNBP1 | FBpp0076237 | FBpp0074817 | Gram-negative bacteria binding protein 3 (GNBP3) encodes a hemolymphatic protein involved in the sensing of glucan (a fungal cell wall component) upstream of the Toll pathway. | Gram-negative bacteria-binding protein 1; Plays a key role in innate immunity by acting as a pattern recognition receptor for beta-1,3-glucan from fungi and lipopolysaccharide from Gram-negative bacteria. Upon recognition of invading micro-organism-derived products, acts upstream of protease spz processing enzyme SPE to activate the Toll pathway and to induce the expression of antimicrobial peptides drosomycin, cecropin and attacin. Belongs to the insect beta-1,3-glucan binding protein family. | 0.581 |
GNBP3 | grass | FBpp0076237 | FBpp0084482 | Gram-negative bacteria binding protein 3 (GNBP3) encodes a hemolymphatic protein involved in the sensing of glucan (a fungal cell wall component) upstream of the Toll pathway. | Gram-positive Specific Serine protease (grass) encodes a secreted serine protease that is involved downstream of the microbial sensing receptors encoded by GNBP3 and PGRP-SA in the activation of the Toll pathway during the immune response. It functions downstream of the serine protease encoded by modSP and upstream of the enzyme encoded by SPE, which cleaves the product of spz; Belongs to the peptidase S1 family. CLIP subfamily. | 0.552 |
GNBP3 | modSP | FBpp0076237 | FBpp0082798 | Gram-negative bacteria binding protein 3 (GNBP3) encodes a hemolymphatic protein involved in the sensing of glucan (a fungal cell wall component) upstream of the Toll pathway. | Modular serine protease non-catalytic chain; Serine protease that plays a key role in innate immunity by activating the Toll pathway in response to infection with Gram-positive bacteria and fungi. During Gram- positive infection, acts downstream of PGRP-SA and upstream of Grass and Spz, and therefore appears to function in a pathway that links detection of Gram-positive lysine-type peptidoglycans to Toll activation. Functions in a separate pathway to the psh-mediated activation of the Toll pathway. Belongs to the peptidase S1 family. | 0.985 |
GNBP3 | psh | FBpp0076237 | FBpp0074400 | Gram-negative bacteria binding protein 3 (GNBP3) encodes a hemolymphatic protein involved in the sensing of glucan (a fungal cell wall component) upstream of the Toll pathway. | Serine protease persephone; Serine protease that plays a key role in innate immunity in response to Gram-positive bacterial and fungal proteases. Acts as a component of the Toll pathway upstream of protease spz processing enzyme SPE and Tl ligand spz. Nec regulates the cascade by inhibiting psh ; Belongs to the peptidase S1 family. CLIP subfamily. | 0.920 |
GNBP3 | sphe | FBpp0076237 | FBpp0074137 | Gram-negative bacteria binding protein 3 (GNBP3) encodes a hemolymphatic protein involved in the sensing of glucan (a fungal cell wall component) upstream of the Toll pathway. | Spheroide (sphe) encodes a serine protein homologue, a serine protease with no catalytic activity. | 0.628 |
GNBP3 | sphinx1 | FBpp0076237 | FBpp0289592 | Gram-negative bacteria binding protein 3 (GNBP3) encodes a hemolymphatic protein involved in the sensing of glucan (a fungal cell wall component) upstream of the Toll pathway. | Sphinx1 (sphinx1) encodes a protein related to the serine protease homolog, which is strongly expressed in the male accessory gland. | 0.683 |
GNBP3 | spz | FBpp0076237 | FBpp0084507 | Gram-negative bacteria binding protein 3 (GNBP3) encodes a hemolymphatic protein involved in the sensing of glucan (a fungal cell wall component) upstream of the Toll pathway. | Protein spaetzle C-106; Spatzle (spz) encodes a secreted protein which, after cleavage by an extracellular serine protease (encoded by ea or SPE), can induce the dimerization of the product of Tl, and the subsequent activation of the Toll pathway. It contributes to function of the Toll signaling cascade, which plays a key role in various developmental and immune processes, notably embryonic dorso-ventral patterning and regulation of antimicrobial peptides. | 0.805 |
grass | CG10041 | FBpp0084482 | FBpp0423040 | Gram-positive Specific Serine protease (grass) encodes a secreted serine protease that is involved downstream of the microbial sensing receptors encoded by GNBP3 and PGRP-SA in the activation of the Toll pathway during the immune response. It functions downstream of the serine protease encoded by modSP and upstream of the enzyme encoded by SPE, which cleaves the product of spz; Belongs to the peptidase S1 family. CLIP subfamily. | FI16631p1; Serine-type endopeptidase activity. It is involved in the biological process described with: multicellular organism reproduction; proteolysis; Belongs to the peptidase S1 family. | 0.512 |
grass | GNBP1 | FBpp0084482 | FBpp0074817 | Gram-positive Specific Serine protease (grass) encodes a secreted serine protease that is involved downstream of the microbial sensing receptors encoded by GNBP3 and PGRP-SA in the activation of the Toll pathway during the immune response. It functions downstream of the serine protease encoded by modSP and upstream of the enzyme encoded by SPE, which cleaves the product of spz; Belongs to the peptidase S1 family. CLIP subfamily. | Gram-negative bacteria-binding protein 1; Plays a key role in innate immunity by acting as a pattern recognition receptor for beta-1,3-glucan from fungi and lipopolysaccharide from Gram-negative bacteria. Upon recognition of invading micro-organism-derived products, acts upstream of protease spz processing enzyme SPE to activate the Toll pathway and to induce the expression of antimicrobial peptides drosomycin, cecropin and attacin. Belongs to the insect beta-1,3-glucan binding protein family. | 0.605 |
grass | GNBP3 | FBpp0084482 | FBpp0076237 | Gram-positive Specific Serine protease (grass) encodes a secreted serine protease that is involved downstream of the microbial sensing receptors encoded by GNBP3 and PGRP-SA in the activation of the Toll pathway during the immune response. It functions downstream of the serine protease encoded by modSP and upstream of the enzyme encoded by SPE, which cleaves the product of spz; Belongs to the peptidase S1 family. CLIP subfamily. | Gram-negative bacteria binding protein 3 (GNBP3) encodes a hemolymphatic protein involved in the sensing of glucan (a fungal cell wall component) upstream of the Toll pathway. | 0.552 |
grass | modSP | FBpp0084482 | FBpp0082798 | Gram-positive Specific Serine protease (grass) encodes a secreted serine protease that is involved downstream of the microbial sensing receptors encoded by GNBP3 and PGRP-SA in the activation of the Toll pathway during the immune response. It functions downstream of the serine protease encoded by modSP and upstream of the enzyme encoded by SPE, which cleaves the product of spz; Belongs to the peptidase S1 family. CLIP subfamily. | Modular serine protease non-catalytic chain; Serine protease that plays a key role in innate immunity by activating the Toll pathway in response to infection with Gram-positive bacteria and fungi. During Gram- positive infection, acts downstream of PGRP-SA and upstream of Grass and Spz, and therefore appears to function in a pathway that links detection of Gram-positive lysine-type peptidoglycans to Toll activation. Functions in a separate pathway to the psh-mediated activation of the Toll pathway. Belongs to the peptidase S1 family. | 0.931 |
grass | psh | FBpp0084482 | FBpp0074400 | Gram-positive Specific Serine protease (grass) encodes a secreted serine protease that is involved downstream of the microbial sensing receptors encoded by GNBP3 and PGRP-SA in the activation of the Toll pathway during the immune response. It functions downstream of the serine protease encoded by modSP and upstream of the enzyme encoded by SPE, which cleaves the product of spz; Belongs to the peptidase S1 family. CLIP subfamily. | Serine protease persephone; Serine protease that plays a key role in innate immunity in response to Gram-positive bacterial and fungal proteases. Acts as a component of the Toll pathway upstream of protease spz processing enzyme SPE and Tl ligand spz. Nec regulates the cascade by inhibiting psh ; Belongs to the peptidase S1 family. CLIP subfamily. | 0.543 |