STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
grassGram-positive Specific Serine protease (grass) encodes a secreted serine protease that is involved downstream of the microbial sensing receptors encoded by GNBP3 and PGRP-SA in the activation of the Toll pathway during the immune response. It functions downstream of the serine protease encoded by modSP and upstream of the enzyme encoded by SPE, which cleaves the product of spz; Belongs to the peptidase S1 family. CLIP subfamily. (377 aa)    
Predicted Functional Partners:
sphinx1
Sphinx1 (sphinx1) encodes a protein related to the serine protease homolog, which is strongly expressed in the male accessory gland.
     
 0.944
spirit
Serine protease immune response integrator, isoform A; Serine-type endopeptidase activity; Belongs to the peptidase S1 family.
  
 
0.940
sphe
Spheroide (sphe) encodes a serine protein homologue, a serine protease with no catalytic activity.
  
  
0.932
modSP
Modular serine protease non-catalytic chain; Serine protease that plays a key role in innate immunity by activating the Toll pathway in response to infection with Gram-positive bacteria and fungi. During Gram- positive infection, acts downstream of PGRP-SA and upstream of Grass and Spz, and therefore appears to function in a pathway that links detection of Gram-positive lysine-type peptidoglycans to Toll activation. Functions in a separate pathway to the psh-mediated activation of the Toll pathway. Belongs to the peptidase S1 family.
   
 
0.931
sphinx2
Sphinx2, isoform B; Sphinx2 (sphinx2) encodes a protein related to the serine protease homolog, which is strongly expressed in the male accessory gland.
     
  0.900
GNBP1
Gram-negative bacteria-binding protein 1; Plays a key role in innate immunity by acting as a pattern recognition receptor for beta-1,3-glucan from fungi and lipopolysaccharide from Gram-negative bacteria. Upon recognition of invading micro-organism-derived products, acts upstream of protease spz processing enzyme SPE to activate the Toll pathway and to induce the expression of antimicrobial peptides drosomycin, cecropin and attacin. Belongs to the insect beta-1,3-glucan binding protein family.
   
 
 0.605
GNBP3
Gram-negative bacteria binding protein 3 (GNBP3) encodes a hemolymphatic protein involved in the sensing of glucan (a fungal cell wall component) upstream of the Toll pathway.
   
 
 0.552
psh
Serine protease persephone; Serine protease that plays a key role in innate immunity in response to Gram-positive bacterial and fungal proteases. Acts as a component of the Toll pathway upstream of protease spz processing enzyme SPE and Tl ligand spz. Nec regulates the cascade by inhibiting psh ; Belongs to the peptidase S1 family. CLIP subfamily.
  
 
0.543
spz
Protein spaetzle C-106; Spatzle (spz) encodes a secreted protein which, after cleavage by an extracellular serine protease (encoded by ea or SPE), can induce the dimerization of the product of Tl, and the subsequent activation of the Toll pathway. It contributes to function of the Toll signaling cascade, which plays a key role in various developmental and immune processes, notably embryonic dorso-ventral patterning and regulation of antimicrobial peptides.
   
 
 0.540
CG10041
FI16631p1; Serine-type endopeptidase activity. It is involved in the biological process described with: multicellular organism reproduction; proteolysis; Belongs to the peptidase S1 family.
  
     0.512
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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